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 Cell Counting Kit-8 (CCK-8试剂盒)

  产品编号C0038
  产品包装: 500次
  产品价格: 398.00元
产品编号 产品名称 产品包装 产品价格
C0038 Cell Counting Kit-8 (CCK-8试剂盒) 500次 398.00元

      Cell Counting Kit-8,简称CCK-8试剂盒或CCK8试剂盒,是一种基于WST-8而广泛应用于细胞增殖和细胞毒性的快速、高灵敏度检测的试剂盒。
      WST-8是一种类似于MTT的化合物,在电子耦合试剂存在的情况下,可以被线粒体内的一些脱氢酶还 原生成橙黄色的
formazan(参考图1)。细胞增殖越多越快,则颜色越深;细胞毒性越大,则颜色越浅。对于同样的细胞,颜色的深浅和细胞数目呈线性关系。


图1. WST-8检测原理图 (EC=electron coupling reagent,即电子耦合试剂)

      WST-8是MTT的一种升级替代产品,和MTT或其它MTT类似产品如XTT、MTS等相比有明显的优点。首先,MTT被线粒体内的一些脱氢酶还原生成的formazan不是水溶性的,需要有特定的溶解液来溶解;而WST-8和XTT、MTS产生的formazan都是水溶性的,可以省去后续的溶解步骤。其次,WST-8产生的formazan比XTT和MTS产生的formazan更易溶解。再次,WST-8比XTT和MTS更加稳定,使实验结果更加稳定。另外,WST-8和MTT、XTT等相比线性范围更宽,灵敏度更高。
      WST-8和WST-1相比,检测灵敏度更高,更易溶解,并且更加稳定。
      本试剂盒可以用于细胞因子等诱导的细胞增殖检测,也可以用于抗癌药物等对细胞有毒试剂诱导的细胞毒性检测,或一些药物诱导的细胞生长抑制检测。
      本试剂盒检测非常便捷。试剂盒仅一管已经配制好的含有WST-8的CCK-8溶液,无须再进行任何配制等操作。无须使用同位素,所有的检测步骤仅在同一块96孔板内完成。不必洗涤细胞,不必收集细胞,也不必采用额外的步骤去溶解formazan。可以用于大批量样品的检测。
      酚红和血清对本试剂盒的测定无明显影响。
      WST-8对细胞无明显毒性。加入CCK-8溶液显色后,可以在不同时间反复用酶标仪读板,使检测时间更加灵活,便于找到最佳测定时间。
      碧云天各种细胞增殖和细胞毒性检测试剂盒的比较和选择,请参考http://www.beyotime.com/cell-proliferation.htm
      本试剂盒可以测定500个样品。
包装清单:

产品编号 产品名称 包装
C0038 CCK-8溶液 5ml
说明书 1份

保存条件:
      4℃避光保存一年有效,-20℃避光保存两年有效。
注意事项:
      由于使用96孔板进行检测,如果细胞培养时间较长,一定要注意蒸发问题。一方面,由于96孔板周围一圈最容易蒸发,可以采取弃用周围一圈的办法,改加相同量的PBS、水或培养液;另一方面,可以把96孔板置于靠近培养箱内水源的地方,以缓解蒸发。
      本试剂盒的检测依赖于脱氢酶催化的反应,所以还原剂(例如一些抗氧化剂)会干扰检测,如果待检测体系中存在较多的还原剂,需设法去除。
      用酶标仪检测前需确保每个孔内没有气泡,否则会干扰测定。
      本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
      为了您的安全和健康,请穿实验服并戴一次性手套操作。

使用说明:
1. 通常细胞增殖实验每孔加入100微升2000个细胞,细胞毒性实验每孔加入100微升5000个细胞(具体每孔所用的细胞的数目,需根据细胞的大小、细胞增殖速度的快慢等因素决定)。按照实验需要,进行培养并给予0-10微升特定的药物刺激。
2. 每孔加入10微升CCK-8溶液。如果起始的培养体积为200微升,则需加入20微升CCK-8溶液,其它情况以此类推。可以用加了相应量细胞培养液和CCK-8溶液但没有加入细胞的孔作为空白对照。如果担心所使用的药物会干扰检测,需设置加了相应量细胞培养液、药物和CCK-8溶液但没有加入细胞的孔作为空白对照。
3. 在细胞培养箱内继续孵育0.5-4小时,对于大多数情况孵育1小时就可以了。时间的长短根据细胞的类型和细胞的密度等实验情况而定,初次实验时可以在0.5、1、2和4小时后分别用酶标仪检测,然后选取吸光度范围比较适宜的一个时间点用于后续实验。
4. 在450nm测定吸光度。如无450nm滤光片,可以使用420-480nm的滤光片。可以使用大于600nm的波长,例如650nm,作为参考波长进行双波长测定。
常见问题:
1. CCK-8溶液对细胞的毒性大小如何?
CCK-8溶液对细胞的毒性非常低,通常观察不到细胞毒性。细胞在CCK-8法检测后仍然可以正常生长,并可以用于其它的细胞实验。但为了避免CCK-8溶液可能带来的对于后续检测的影响,除非该细胞极难获得,否则不推荐把CCK-8溶液孵育过的细胞用于其它实验。
2. 如果吸光度值太低,可以采取什么办法?
a. 适当增加细胞数量。
b. 延长加入CCK-8试剂后的孵育时间。

相关产品:

产品编号 产品名称 包装
C0009 MTT细胞增殖及细胞毒性检测试剂盒 500次
C0035 WST-1细胞增殖及细胞毒性检测试剂盒 100次
C0036 WST-1细胞增殖及细胞毒性检测试剂盒 500次
C0037 Cell Counting Kit-8(CCK-8试剂盒) 100次
C0038 Cell Counting Kit-8(CCK-8试剂盒) 500次
C0039 Cell Counting Kit-8(CCK-8试剂盒) 2500次
C0040 Cell Counting Kit-8(CCK-8试剂盒) 10000次
C0041 Enhanced Cell Counting Kit-8(增强型CCK-8试剂盒) 100次
C0042 Enhanced Cell Counting Kit-8(增强型CCK-8试剂盒) 500次
C0043 Enhanced Cell Counting Kit-8(增强型CCK-8试剂盒) 2500次
C0046 Enhanced Cell Counting Kit-8(增强型CCK-8试剂盒) 10000次
相关产品请点击如下按钮:

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56.Du X, Zhao B, Li J, Cao X, Diao M, Feng H, Chen X, Chen Z, Zeng X.
Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting the dendritic cell maturation and suppressing Treg frequency in mice.
Int Immunopharmacol. 2012 Dec;14(4):463-70.
57.Zhou BR, Yin HB, Xu Y, Wu D, Zhang ZH, Yin ZQ, Permatasari F, Luo D.
Baicalin protects human skin fibroblasts from ultraviolet A radiation-induced oxidative damage and apoptosis.
Free Radic Res. 2012 Dec;46(12):1458-71.
58.Shi W, Nie D, Jin G, Chen W, Xia L, Wu X, Su X, Xu X, Ni L, Zhang X, Zhang X, Chen J.
BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic braininjury therapy.
Biomaterials.2012 Apr;33(11):3119-26.
59.Gao X, Lu Y, Xing Y, Ma Y, Lu J, Bao W, Wang Y, Xi T.
A novel anticancer and antifungus phenazine derivative from a marine actinomycete BM-17.
Microbiol Res. 2012 Dec 20;167(10):616-22.
60.Huang G, Ji S, Luo P, Zhang Y, Wang G, Zhu S, Xiao S, Xia Z.
Evaluation of dermal substitute in a novel co-transplantation model with autologous epidermal sheet.
PLoS One. 2012 Nov;7(11):e49448. 
61.Zhou X, Shi Y , Ren L, Bao S, Han Y, Wu S, Zhang H, Zhong L ,Zhang Q.
Controllable synthesis, magnetic and biocompatible properties of Fe3O4 and α-Fe2O3 nanocrystals.
Journal of Solid State Chemistry.2012 Dec;196:138–44.
62.Liu S, Sun L , Wang J, Ma G, Su Z, Hu T.
Mono-PEGylation of ribonuclease A: High PEGylation efficiency by thiolation with small molecular weight reagent.
Process Biochemistry. 2012 Sep; 47(9):1364–70.
63.Cao X, Yue L, Song J, Wu Q, Li N, Luo L, Lan L, Yin Z.
Inducible HSP70 antagonizes IL-1β cytocidal effects through inhibiting NF-kB activation via destabilizing TAK1 inHeLa cells.
PLoS One. 2012 Nov;7(11):e50059.
64.Chen L, Hu P, Zhang L, Huang S, Luo L, Huang C.
Toxicity of graphene oxide and multi-walled carbon nanotubes against human cells and zebrafish.
Science China Chemistry. 2012 Oct;55(10):2209-16.
65.He Q, Ma M, Wei C, Shi J.
Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs andluminescence imaging.
Biomaterials. 2012 Jun;33(17):4392-402.
66.Miao S, Sun L, Wang P, Liu R, Su Z, Zhang S.
Soybean oil‐based polyurethane networks as candidate biomaterials: Synthesis and biocompatibility.
European Journal of Lipid Science and Technology. 2012 Oct;114(10):1165-74.
67.Cai L, Cai JJ, Liu HP, Fan DQ, Peng H, Wang KJ.
Recombinant medaka (Oryzias melastigmus) pro-hepcidin: Multifunctional characterization.
Comp Biochem Physiol B Biochem Mol Biol. 2012 Feb;161(2):140-7.
68.Yao W, Yu X, Fang Z, Yin P, Zhao C, Li N, Wang L, Li Z, Zha X.
Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin β1-actin complex in breast cancercells.
J Cell Mol Med. 2012 Apr;16(4):824-35.
69.Wang W, Tao R, Tong Z, Ding Y, Kuang R, Zhai S, Liu J, Ni L.
Effect of a novel antimicrobial peptide chrysophsin-1 on oral pathogens and Streptococcus mutans biofilms.
Peptides. 2012 Feb;33(2):212-9.
70.Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T, Zhang XL.
Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells.
Int J Nanomedicine. 2012;7:5593-602.
71.Yang ZR, Dong WG, Lei XF, Liu M, Liu QS.
Overexpression of Dickkopf-3 induces apoptosis through mitochondrial pathway in human colon cancer.
World J Gastroenterol. 2012 Apr 14;18(14):1590-601. 
72.Qing H, Gong W, Che Y, Wang X, Peng L, Liang Y, Wang W, Deng Q, Zhang H, Jiang B.
PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation.
Tumour Biol. 2012 Aug;33(4):985-94.
73.Su Y, Bi J, Wang Y, Tan Y, Yang J, Liu H, Gu W.
Chemical constituents from Chirita longgangensis var. hongyao with inhibitory activity against porcine respiratory and reproductive syndrome virus.
J. Braz. Chem. Soc.2012 Oct;23(10):1925-32.
74.Wang M, Liu X, Cao C, Wang L.
Highly luminescent CuInS2–ZnS nanocrystals: achieving phase transfer and nuclear homing property simultaneously through simple TTAB modification.
J. Mater. Chem.2012 Aug;41:21979-86 .
75.Shen Y, Zhao L, Qi L, Qiao J, Mao L, Chen Y.
Reactive polymer as a versatile toolbox for construction of multifunctional superparamagnetic nanocomposites.
Chemistry. 2012 Oct 22;18(43):13755-61. 
76.Li XX, He GR, Mu X, Xu B, Tian S, Yu X, Meng FR, Xuan ZH, Du GH.
Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brainmitochondria.
Eur J Pharmacol. 2012 Jan 15;674(2-3):227-33. 
77.Zhong ZN, Zhu SF, Yuan AD, Lu GH, He ZY, Fa ZQ, Li WH.
Potential of placenta-derived mesenchymal stem cells as seed cells for bone tissue engineering: preliminary study of osteoblastic differentiation and immunogenicity.
Orthopedics. 2012 Sep;35(9):779-88.
78.Feng YJ, Zhang BY, Yao RY, Lu Y.
Muscarinic acetylcholine receptor M3 in proliferation and perineural invasion of cholangiocarcinoma cells.
Hepatobiliary Pancreat Dis Int. 2012 Aug 15;11(4):418-23.
79.Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL.
Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis andsuppression of angiogenesis.
PLoS One. 2012;7(8):e42146.
80.Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D, Liu X, Ma H, Guo M, Spear BT, Gong Y, Ma C.
Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression ofCyclins A and E.
Gastroenterology. 2012 Jun;142(7):1559-70.
81.Shi S, Jia J, Guo X, Zhao Y, Liu B, Chen D, Guo Y, Zhang X.
Toxicity of iron oxide nanoparticles against osteoblasts.
Journal of Nanoparticle Research. 2012 Aug;14:1091.
82.Yang ZR, Liu M, Peng XL, Lei XF, Zhang JX, Dong WG.
Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro.
Biochem Biophys Res Commun. 2012 May 11;421(3):627-33.
83.Tu Z, Li H, Ma Y, Tang B, Tian J, Akers W, Achilefu S, Gu Y.
The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression.
Mol Cell Biochem. 2012 Jul;366(1-2):111-22.
84.Wang M, Liu X, Cao C, Shi C.
Synthesis of band-gap tunable Cu–In–S ternary nanocrystals in aqueous solution.
RSC Advances. 2012 Feb;7:2666-2670.
85.Wu D, Guo Z, Min W, Zhou B, Li M, Li W, Luo D.
Upregulation of TCTP expression in human skin squamous cell carcinoma increases tumor cell viability throughanti-apoptotic action of the protein.
Exp Ther Med. 2012 Mar;3(3):437-442. 
86.He H, Yang T, Jia S, Zhang R, Tu P, Gao J, Yuan Y, Han W, Yu Y.
Expression and purification of bioactive high-purity human S100A6 in Escherichia coli.
Protein Expr Purif. 2012 May;83(1):98-103.
87.Shao X, Hu Z, Hu C, Bu Q, Yan G, Deng P, Lv L, Wu D, Deng Y, Zhao J, Zhu R, Li Y, Li H, Xu Y, Yang H, Zhao Y, Cen X.
Taurine protects methamphetamine-induced developmental angiogenesis defect through antioxidant mechanism.
Toxicol Appl Pharmacol. 2012 May 1;260(3):260-70. 
88.Zhang L, Yang M, Gan L, He T, Xiao X, Stewart MD, Liu X, Yang L, Zhang T, Zhao Y, Fu J.
DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis.
Int J Biol Sci. 2012;8(8):1178-87. 
89.Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB, Pribis JP, Billiar TR, Sun X, Bermudez CA, Toyoda Y, Nakao A.
Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.
Cardiovasc Res. 2012 Apr 1;94(1):144-53.
90.Li X, Zheng SL, Li X, Li JL, Qiang O, Liu R, He L.
Synthesis and anti-breast cancer activity of new indolylquinone derivatives.
Eur J Med Chem. 2012 Aug;54:42-8.
91.Ning L, Li X, Ding X, Yin Y, Li G.
An iRGD Based Strategy to Study Electrochemically the Species Inside a Cell.
Int J Mol Sci. 2012;13(8):10424-31.
92.Zhou X, Meng Q, Xu X, Zhi T, Shi Q, Wang Y, Yu R.
Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinasepathway.
Biochem Biophys Res Commun. 2012 Oct 26;427(3):574-80.
93.Xie Y, Liao J, Li M, Wang X, Yang Y, Ge J, Chen R, Chen H.
Impaired cardiac microvascular endothelial cells function induced by Coxsackievirus B3 infection and its potentialrole in cardiac fibrosis.
Virus Res. 2012 Oct;169(1):188-94.
94.Zhang J, Song W, Guo J, Zhang J, Sun Z, Li L, Ding F, Gao M.
Cytotoxicity of different sized TiO2 nanoparticles in mouse macrophages.
Toxicol Ind Health. 2013 Jul;29(6):523-33.
96.Liu Z, Zhang J, Huang X, Huang L, Li S, Wang Z.
Magnesium sulfate inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated RAW264.7 macrophages in vitro.
J Surg Res. 2013 Jan;179(1):e189-95.
97. Xia H, Liang W, Song Q, Chen X, Chen X, Hong J.
The in vitro study of apoptosis in NB4 cell induced by citral.
Cytotechnology. 2013 Jan;65(1):49-57.
97.Wu Q, Wang C, Guo L, Ge Q, Lu Z.
Identification and characterization of novel microRNA candidates from deep sequencing.
Clin Chim Acta. 2013 Jan 16;415:239-44.
98.Hu Y, Qi Y, Liu H, Fan G, Chai Y.
Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography-mass spectrometry based metabolic profiling.
Biochim Biophys Acta. 2013 Mar;1830(3):2779-89.
99.Shen XL, Zhang Y, Xu W, Liang R, Zheng J, Luo Y, Wang Y, Huang K.
An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of ochratoxin A in HEK293 cells.
J Proteomics. 2013 Jan 14;78:398-415.
100.Su Y, Xu JJ, Bi JL, Wang YH, Hu GW, Yang J, Yin GF, Long CL.
Chemical constituents of Arisaema franchetianum tubers.
J Asian Nat Prod Res. 2013;15(1):71-7. 
101.Guo Z, Zhou B, Liu W, Xu Y, Wu D, Yin Z, Permatasari F, Luo D.
MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells.
J Dermatol Sci. 2013 Jan;69(1):68-76. 
102.Ma GF, Chen SY, Sun ZR, Miao Q, Liu YM, Zeng XQ, Luo TC, Ma LL, Lian JJ, Song DL.
FoxP3 inhibits proliferation and induces apoptosis of gastric cancer cells by activating the apoptotic signalingpathway.
Biochem Biophys Res Commun. 2013 Jan 11;430(2):804-9.
103.Zhao L, Wang H, Huo K, Zhang X, Wang W, Zhang Y, Wu Z, Chu PK.
The osteogenic activity of strontium loaded titania nanotube arrays on titanium substrates.
Biomaterials. 2013 Jan;34(1):19-29. 
104.Pang H, Wu XH, Fu SL, Luo F, Zhang ZH, Hou TY, Li ZQ, Chang ZQ, Yu B, Xu JZ.
Co-culture with endothelial progenitor cells promotes survival, migration, and differentiation of osteoclastprecursors.
Biochem Biophys Res Commun. 2013 Jan 11;430(2):729-34. 
105.Gao C, Cai Y, Kong X, Han G, Yao J.
Development and characterization of injectable chitosan-based hydrogels containing dexamethasone/rhBMP-2 loaded hydroxyapatite nanoparticles.
Materials Letters. 2013 Feb;93(15):312–5.
106.Chang Y, Huang X, Liu Z, Han G, Huang L, Xiong YC, Wang Z.
Dexmedetomidine inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activatedmacrophages in vitro.
J Surg Res. 2013 May;181(2):308-14.
107.Wang Y, Wang K, Li H, Chen L, Xu F, Wu T.
Effects of different sustained hydrostatic pressures on connexin 43 in human bladder smooth muscle cells.
Urol Int. 2013;90(1):75-82. 
108.Li Y, Wang Y, Wang P, Zhang B, Yan W, Sun J, Pan J.
In vitro cytocompatibility evaluation of MGF-Ct24E chemically grafted and physically blended with maleicanhydride modified poly(D, L-lactic acid).
J Biomater Sci Polym Ed. 2013;24(7):849-64. 
109.Alibrahim A, Zhao LY, Bae CY, Barszczyk A, Sun CL, Wang GL, Sun HS.
Neuroprotective effects of volume-regulated anion channel blocker DCPIB on neonatal hypoxic-ischemic injury.
Acta Pharmacol Sin. 2013 Jan;34(1):113-8.
110.Shu G, Xie B, Ren F, Liu DC, Zhou J, Li Q, Chen J, Yuan L, Zhou J.
Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells.
Cell Oncol (Dordr). 2013 Apr;36(2):121-9.
111.Kuang P, Zhao W, Su W, Zhang Z, Zhang L, Liu J, Ren G, Yin Z, Wang X.
18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediatedimmunosuppression in mice.
Int J Cancer. 2013 Apr 15;132(8):1831-41.
112.Liu Z, Chang Y, Zhang J, Huang X, Jiang J, Li S, Wang Z.
Magnesium deficiency promotes secretion of high-mobility group box 1 protein from lipopolysaccharide-activatedmacrophages in vitro.
J Surg Res. 2013 Apr;180(2):310-6.
113.Zhang M, Qiu Z, Li Y, Yang Y, Zhang Q, Xiang Q, Su Z, Huang Y.
Construction and characterization of a recombinant human beta defensin 2 fusion protein targeting the epidermalgrowth factor receptor: in vitro study.
Appl Microbiol Biotechnol. 2013 May;97(9):3913-23. 
114.Ji X, Lu W, Zhou H, Han D, Yang L, Wu H, Li J, Liu H, Zhang J, Cao P, Zhang S.
Covalently dimerized Camelidae antihuman TNFa single-domain antibodies expressed in yeast Pichia pastorisshow superior neutralizing activity.
Appl Microbiol Biotechnol. 2013 Oct;97(19):8547-58.
115.Shan D, Shi Y, Duan S, Wei Y, Cai Q, Yang X.
Electrospun magnetic poly(l-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles.
Mater Sci Eng C Mater Biol Appl. 2013 Aug 1;33(6):3498-505.
116.Xie H, Li J, Li L, Dong Y, Chen GQ, Chen KC.
Enhanced proliferation and differentiation of neural stem cells grown on PHA films coated with recombinantfusion proteins.
Acta Biomater. 2013 Aug;9(8):7845-54. 
117.Liu W, Lin J, Cheng Y, Zhang L , Huang J, Wu Z, Wang F, Xu S, Lin W, Lan W, Yang G.
FIM-A, a Phosphorus-Containing Sirolimus, Inhibits the Angiogenesis and Proliferation of Osteosarcomas.
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 2013;20(7)319-26.
118.Wang H, Jiang W, Yuan L, Wang L, Chen H.
Reductase-like activity of silicon nanowire arrays.
ACS Appl Mater Interfaces. 2013 Mar 13;5(5):1800-5.
119.Zhan XX, Liu Y, Yang JF, Wang GY, Mu L, Zhang TS, Xie XL, Wang JH, Liu YM, Kong QF, Li HL, Sun B.Immunology.
All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocytedevelopment.
Immunology. 2013 Apr;138(4):333-45.
120.Bai J, Mei P, Zhang C, Chen F, Li C, Pan Z, Liu H, Zheng J.
BRG1 is a prognostic marker and potential therapeutic target in human breast cancer.
PLoS One. 2013;8(3):e59772. 
121.Feng H, Du X, Tang J, Cao X, Han X, Chen Z, Chen Y, Zeng X.
Enhancement of the immune responses to foot-and-mouth disease vaccination in mice by oral administration of a Novel polysaccharide from the roots of Radix Cyathulae officinalis Kuan (RC).
Cell Immunol. 2013 Feb;281(2):111-21.
122.Yang Q, Sui G, Shi Y, Duan S, Bao J, Cai Q, Yang X.
Osteocompatibility characterization of polyacrylonitrile carbon nanofibers containing bioactive glass nanoparticles.
Carbon.2013 
May;56:288–95.
123.
Pang XL, He G, Liu YB, Wang Y, Zhang B.
Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation.
World J Gastroenterol. 2013 Mar 21;19(11):1736-48.
124.Wang S, Pang T, Gao M, Kang H, Ding W, Sun X, Zhao Y, Zhu W, Tang X, Yao Y, Hu X.
HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer.
FEBS Lett. 2013 Mar 18;587(6):690-7.
125.Yang L, Zhou L, Zong X, Cao X, Ji X, Gu W, Zhang S.
Characterization of the molecular structure, expression and bioactivity of the TNFSF13B (BAFF) gene of the SouthAfrican clawed frog, Xenopus laevis.
Int Immunopharmacol. 2013 Mar;15(3):478-87.
126.Wu K, Song W, Zhao L, Liu M, Yan J, Andersen MØ, Kjems J, Gao S, Zhang Y.
MicroRNA functionalized microporous titanium oxide surface by lyophilization with enhanced osteogenic activity.
ACS Appl Mater Interfaces. 2013 Apr 10;5(7):2733-44. 
127.Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z, Qu B, Hoth M, Ni Q, Zha X, Yu X.
Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.
Curr Mol Med. 2013 Mar;13(3):417-28.
128.Bai J, Yong HM, Chen FF, Mei PJ, Liu H, Li C, Pan ZQ, Wu YP, Zheng JN.
Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer.
Ann Oncol. 2013 Aug;24(8):2016-22.
129.Zou X, Yu C, Zhang H.
In Vitro Analyses of Effect of Light on Toxicity of Titanium Dioxide Nanoparticles to Tetrahymena Pyriformis Using Fourier Transform Infrared Spectra.
An International Journal for Rapid Communication. 2013 Jan;46(8):597-608.

130.Xu D, Yang W, Hu Y, Luo Z, Li J, Hou Y, Liu Y, Cai K.
Surface functionalization of titanium substrates with cecropin B to improve their cytocompatibility and reduceinflammation responses.
Colloids Surf B Biointerfaces. 2013 May 9;110C:225-235.
131.Shen Z, Jiang X, Zeng C, Zheng S, Luo B, Zeng Y, Ding R, Jiang H, He Q, Guo J, Jie W.
High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinomaprogression.
BMC Cancer. 2013 Apr 15;13:192. 
132.Jia D, Duan F, Peng P, Sun L, Liu X, Wang L, Wu W, Ruan Y, Gu J.
Up-regulation of RACK1 by TGF-β1 promotes hepatic fibrosis in mice.
PLoS One. 2013;8(3):e60115.
133.Zhu C, Qin H, Cheng T, Tan HL, Guo YY, Shi SF, Chen DS, Zhang XL.
Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38MAPK and NF-κB pathways.
Int J Mol Med. 2013 Jun;31(6):1484-94.
134.Zhang X, Cai Z, Wang G, Wang H, Liu Z, Guo X, Yang C, Wang X, Wang H, Shu C, Xiao L.
F-actin may play an important role in IL-1β-stimulated hippocampal neurons.
Behav Brain Res. 2013 Apr15;243:165-70.

135.Wang Q, Shen L, Huang W, Song Y, Xiao L, Xu W, Liu Y.
Vasculogenesis of decidua side population cells of first-trimester pregnancy.
Stem Cell Res Ther. 2013 May 7;4(3):50.
136.Zhen Y, Ye Y, Yu X, Mai C, Zhou Y, Chen Y, Yang H, Lyu X, Song Y, Wu Q, Fu Q, Zhao M, Hua S, Wang H, Liu Z, Zhang Y, Fang W.
Reduced CTGF Expression Promotes Cell Growth, Migration, and Invasion in Nasopharyngeal Carcinoma.
PLoS One. 2013 Jun 3;8(6):e64976.
137.Shi SF, Zhang XL, Zhu C, Chen DS, Guo YY.
Ultrasonically enhanced rifampin activity against internalized Staphylococcus aureus.
Exp Ther Med. 2013 Jan;5(1):257-262. 
138.Duan S, Yang X, Mao J, Qi B, Cai Q, Shen H, Yang F, Deng X, Wang S.
Osteocompatibility evaluation of poly (glycine ethyl ester-co-alanine ethyl ester) phosphazene with honeycomb-patterned surface topography.
J Biomed Mater Res A. 2013Feb;101(2):307-17.
139.Li G, Liu Y, Su Z, Ren S, Zhu G, Tian Y, Qiu Y.
MicroRNA-324-3p regulates nasopharyngeal carcinoma radioresistance by directly targeting WNT2B.
Eur J Cancer. 2013 Jul;49(11):2596-607.
140.Jiao Q, Wang H, Hu Z, Zhuang Y, Yang W, Li M, Yu X, Liang J, Guo Y, Zhang H, Chen X, Cheng R, Yao Z.
Lidocaine inhibits staphylococcal enterotoxin-stimulated activation of peripheral blood mononuclear cells frompatients with atopic dermatitis.
Arch Dermatol Res. 2013 Sep;305(7):629-36. 

141.Xu Y, Wu J, Wang H, Li H, Di N, Song L, Li S, Li D, Xiang Y, Liu W, Mo X, Zhou Q.
Fabrication of Electrospun Poly(L-Lactide-co-ε-Caprolactone)/Collagen Nanoyarn Network as a Novel, Three-Dimensional, Macroporous, Aligned Scaffold for Tendon Tissue Engineering.
Tissue Eng Part C Methods. 2013 Dec;19(12):925-36.
142.Lv L, Liu H, Chen X, Yang Z.
Glutathione-triggered formation of molecular hydrogels for 3D cell culture.
Colloids Surf B Biointerfaces. 2013 Aug 1;108:352-7.
143.Xia J, Wang F, Wang L, Fan Q.
Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-κB signaling pathway.
Tumour Biol. 2013 Feb;34(1):317-28. 
144.Jiang ZQ, Yan XJ, Bi L, Chen JP, Zhou Q, Chen WP.
Mechanism for hepato-protective action of Liangxue Huayu Recipe (LHR): Blockade of mitochondrial cytochrome c release and caspase activation.
J Ethnopharmacol. 2013 Jul 30;148(3):851-60.
145.Wu S, Ju GQ, Du T, Zhu YJ, Liu GH.
Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladdertumor cell growth in vitro and in vivo.
PLoS One. 2013 Apr 12;8(4):e61366. 
146.Yang C, Wu D, Jia J, Liu D, Li Z, Zhang C, Li M, Xia Y.
DLC1 as a regulator of proliferation, invasion, cell cycle, and apoptosis in cutaneous squamous cell carcinoma.
Tumour Biol. 2013 Oct;34(5):2633-43.
147.Zhou X, Qian J, Hua L, Shi Q, Liu Z, Xu Y, Sang B, Mo J, Yu R.
Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association andactivation.
J Mol Neurosci. 2013 Jan;49(1):130-9.
148.Jin Y, Peng D, Shen Y, Xu M, Liang Y, Xiao B, Lu J.
MicroRNA-376c Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting to Transforming GrowthFactor-Alpha.
DNA Cell Biol. 2013 Jun;32(6):302-9. 
149.Hu X , Liu R, Zhu N.
Enhancement of humoral and cellular immune responses by monophosphoryl lipid A (MPLA) as an adjuvant to the rabies vaccine in BALB/c mice.
Immunobiology. 2013 Dec;218(12):1524–8.
150.Xia L, Huang Q, Shi J, Nie D, Gong M, Gong P, Zhao L, Zuo H, Huang H, Ju S, Chen J, Shi W.
PAX3 is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells.
Brain Res. 2013 Jul 12;1521:68-78.
151.Han Y, Guo XH, Zheng QF, Zhu YL, Fan YY, Zhang XY.
Down-regulation of platelet-derived growth factor-D expression blockades NF-κB pathway to inhibit cellproliferation and invasion as well as induce apoptosis in esophageal squamous cell carcinoma.
Mol Biol Rep. 2013 Mar;40(3):2473-83.
152.Wang L, Liang B, Li L, Liu W.
Induction of HepG2 cell apoptosis by Irgarol 1051 through mitochondrial dysfunction and oxidative stresses.
Toxicol In Vitro. 2013 Jul 12;1521:68-78.
153.Gao F, Ding B, Zhou L, Gao X, Guo H, Xu H.
Magnesium sulfate provides neuroprotection in lipopolysaccharide-activated primary microglia by inhibiting NF-κB pathway.
J Surg Res. 2013 Jul 12;1521:68-78.
154.Chen Q, Xue Y, Sun J.
Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo.
Int J Nanomedicine. 2013;8:1129-40. 
155.Chen F, Bai J, Li W, Mei P, Liu H, Li L, Pan Z, Wu Y, Zheng J.
RUNX3 suppresses migration, invasion and angiogenesis of human renal cell carcinoma.
PLoS One. 2013;8(2):e56241. 
156.Chen Q, Sun J.
Implication of Oxidative Stress in Dose-Dependent Toxicity of Silica Nanoparticles in Hepatocytes.
Advanced Materials Research. 2013 Jan;647(1):42-5.
157.Wang W, Liu Z, Qu P, Zhou Z, Zeng Y, Fan J, Liu Y, Guo Y, Qiu J.
Knockdown of Regulator of Cullins-1 (ROC1) Expression Induces Bladder Cancer Cell Cycle Arrest at the G2Phase and Senescence.
PLoS One. 2013 May 8;8(5):e62734. 
158.Zhao C, Yin P, Mei C, Li N, Yao W, Li X, Qi J, Fan K, Li Z, Wang L, Shi Y, Qiu S, Fan J, Zha X.
Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in humanhepatocarcinoma cell lines.
Mol Cell Biochem. 2013 Apr; 376(1-2):111-9.
159.Yu C, Xing F, Tang Z, Bronner C, Lu X, Di J, Zeng S, Liu J.
Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins.
Pharmacol Rep. 2013;65(2):435-44.
160.Tang Y, Wang F, Jin C, Liang H, Zhong X, Yang Y.
Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats.
Environ Toxicol Pharmacol. 2013 Jul;36(1):66-72.
161.Wang XX, Cheng Q, Zhang SN, Qian HY, Wu JX, Tian H, Pei DS, Zheng JN.
PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell.
Tumour Biol. 2013 Oct;34(5):2721-9.

162.Kong CZ, Liu J, Liu L, Zhang Z, Guo KF.
Interactional expression of netrin-1 and its dependence receptor UNC5B in prostate carcinoma.
Tumour Biol. 2013 Oct;34(5):2765-72.
163.Xie B, Zhou J, Shu G, Liu DC, Zhou J, Chen J, Yuan L.
Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumorsuppressive role of klotho in gastric cancer.
Cancer Cell Int. 2013 Feb 21;13(1):18. 
164.Luo DY, Wazir R, Tian Y, Yue X, Wei TQ, Wang KJ.
Integrin αv mediates contractility whereas integrin α4 regulates proliferation of human bladder smooth musclecells via FAK pathway under physiological stretch.
J Urol. 2013 Oct;190(4):1421-9.
165.Hu J, Zhang L, Wang N, Ding R, Cui S, Zhu F, Xie Y, Sun X, Wu D, Hong Q, Li Q, Shi S, Liu X, Chen X.
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyteinteractions.
Kidney Int.2014 Apr;85(4):981-2.
166.
Guo D, Zhao Y, Zhang Y, Wang Q, Huang Z, Ding Q, Guo Z, Zhou X, Zhu L, Gu N.
The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells.
J Biomed Nanotechnol. 2014 Apr;10(4):669-78.

167.Cai W, Dong F, Wang Z, Yang X, Zheng M, Che X.
Heated and humidified CO2 pneumoperitoneum inhibits tumour cell proliferation, migration and invasion in colon cancer.
Int J Hyperthermia. 2014 May;30(3):201-9.
168.Zhang GH, Qin R, Zhang SH, Zhu H.
Effects of vascular endothelial growth factor B on proliferation and migration in EA.Hy926 cells.
Mol Biol Rep. 2014 Feb;41(2):779-85. 
169.Ben Q, An W, Fei J, Xu M, Li G, Li Z, Yuan Y.
Downregulation of L1CAM inhibits proliferation, invasion and arrests cell cycle progression in pancreatic cancer cells in vitro.
Exp Ther Med. 2014 Apr;7(4):785-790. 
170.Yang X, Zhu H, Ge Y, Liu J, Cai J, Qin Q, Zhan L, Zhang C, Xu L, Liu Z, Yang Y, Yang Y,Ma J, Cheng H, Sun X.
Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α.
Tumour Biol. 2014 Oct;35(10):10443-8.
171.Shao S, Li S, Qin Y, Wang X, Yang Y, Bai H, Zhou L, Zhao C, Wang C.
Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia.
Int J Oncol. 2014 May;44(5):1661-8.
172.Xu YY, Wu TT, Zhou SH, Bao YY, Wang QY, Fan J, Huang YP.
Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study.
Int J Clin Exp Pathol. 2014 Jun 15;7(7):3938-47. 
173.Wang F, Xu H, Wang Y, Wang R, Yuan L, Ding H, Song C, Ma S, Peng Z, Peng Z, Zhao P, Xia Q.
Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application.
Acta Biomater. 2014 Dec;10(12):4947-55.
174.Ma S, Liang S, Jiao H, Chi L, Shi X, Tian Y, Yang B, Guan F.
Human umbilical cord mesenchymal stem cells inhibit C6 glioma growth via secretion of dickkopf-1 (DKK1).
Mol Cell Biochem. 2014 Jan;385(1-2):277-86. 
175.Cai XY, Xiong LM, Yang SH, Shao ZW, Xie M, Gao F, Ding F.
Comparison of toxicity effects of ropivacaine, bupivacaine, and lidocaine on rabbit intervertebral disc cells in vitro.
Spine J. 2014 Mar 1;14(3):483-90.
176.Feng X, Lu X, Huang D, Xing J, Feng G, Jin G, Yi X, Li L, Lu Y, Nie D, Chen X, Zhang L, Gu Z, Zhang X.
3D porous chitosan scaffolds suit survival and neural differentiation of dental pulp stem cells.
Cell Mol Neurobiol. 2014 Aug;34(6):859-70.
177.Li Y, Wang S, Wang Z, Qian X, Fan J, Zeng X, Sun Y, Song P, Feng M, Ju D.
Cationic poly(amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular carcinoma cells.
Nanotechnology. 2014 Aug 20;25(36):365101.
178.Li L, Lin M, Li L, Wang R, Zhang C, Qi G, Xu M, Rong R, Zhu T.
Renal telocytes contribute to the repair of ischemically injured renal tubules.
J Cell Mol Med. 2014 Jun;18(6):1144-56.
179.Li PP, Yao QM, Zhou H, Feng LL, Ge XL, Lv X, Chen N, Lu K, Wang X.
Metadherin contribute to BCR signaling in chronic lymphocytic leukemia.
Int J Clin Exp Pathol. 2014 Mar 15;7(4):1588-94. 
180.Shi Y, Yu P, Zeng D, Qian F, Lei X, Zhao Y, Tang B, Hao Y, Luo H, Chen J, Tan Y.
Suppression of vascular endothelial growth factor abrogates the immunosuppressive capability of murine gastric cancer cells and elicits antitumor immunity.
FEBS J. 2014 Sep;281(17):3882-93.
181.Wang B, Lin Q, Shen C, Tang J, Han Y, Chen H.
Hydrophobic modification of polymethyl methacrylate as intraocular lenses material to improve the cytocompatibility.
J Colloid Interface Sci. 2014 Oct 1;431:1-7.
182.Duan S, Yang X, Mei F, Tang Y, Li X, Shi Y, Mao J, Zhang H, Cai Q.
Enhanced osteogenic differentiation of mesenchymal stem cells on poly(l-lactide) nanofibrous scaffolds containing carbon nanomaterials.
J Biomed Mater Res A. 2015 Apr;103(4):1424-35.

183.W
ang Y, Tan B, Xiong X, Li F, Ren W, Kong X, Qiu W, Hardwidge PR, Yin Y.
Methionine deficiency reduces autophagy and accelerates death in intestinal epithelial cells infected with enterotoxigenic Escherichia coli.
Amino Acids.2015 Oct;47(10):2199-204. 
184.Zhou J, Li W, Guo J, Li G, Chen F, Zhou J. 
Downregulation of miR-329 promotes cell invasion by regulating BRD4 and predicts poor prognosis inhepatocellular carcinoma.
Tumour Biol. 2015 Apr;103(4):1424-3569.
185.Wang J, Wang Z, Mo Y, Zeng Z, Wei P, Li T.
Effect of hyperthermic CO2-treated dendritic cell-derived exosomes on the human gastric cancer AGS cell line.
Oncol Lett. 2015 Jul;10(1):71-76.
186.Chen B, Zhang B, Xia L, Zhang J, Chen Y, Hu Q, Zhu C.
Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion,and inducesapoptosis and cell cycle arrest ina human lung adenocarcinoma cell line.
Mol Med Rep. 2015 Dec;12(6):7971-8.
187.Zhu Z, Song L, He J, Sun Y, Liu X, Zou X.
Ectopic expressed long non-coding RNA H19 contributes to malignant cell behavior of ovarian cancer.
Int J Clin Exp Pathol. 2015 Sep 1;8(9):10082-91.
188.Zhang J, Wang M, Zhang Z, Luo Z, Liu F, Liu J.
Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cellsenescence.
Mol Med Rep. 2015 Apr;11(4):3021-6.
189.Ma Y, She XG, Ming YZ, Wan QQ, Ye QF.
MicroRNA 144suppressestumorigenesis of hepatocellular carcinoma by targeting AKT3.
Mol Med Rep. 2015 Feb;11(2):1378-83.
190.Lu M, Sun L, Zhou J, Zhao Y, Deng X.
Dihydroartemisinin-Induced Apoptosis is Associated with Inhibition of Sarco/Endoplasmic Reticulum CalciumATPase Activity in Colorectal Cancer.
Cell Biochem Biophys.2015 Sep;73(1):137-45;
191.Yan J, Zhou Y, Chen D, Li L, Yang X, You Y, Ling X.
Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells.
J Cancer. 2015 Jan 5;6(2):151-9.
192.Wang Z, Zhang D, Hu Z, Cheng J, Zhuo C, Fang X, Xing Y.
MicroRNA-26a-modified adipose-derived stem cells incorporated witha porous hydroxyapatite scaffold improvethe repair of bone defects.
Mol Med Rep. 2015 Sep;12(3):3345-50.
193.Jiang SL, Pan DY, Gu C, Qin HF, Zhao SH.
Annexin A2 silencing enhances apoptosis of human umbilical vein endothelial cells in vitro.
Asian Pac J Trop Med. 2015 Nov;8(11):952-957.
194.Zhou B, Yang J, Shu B, Liu K, Xue L, Su N, Liu J, Xi T.
Overexpression of astrocyte-elevated gene-1 is associated with ovarian cancer development and progression.
Mol Med Rep. 2015 Apr;11(4):2981-90.
195.Zhu H, Zhu X, Cheng G, Zhou M, Lou W.
Downregulation of microRNA-21 enhances radiosensitivity in nasopharyngeal carcinoma.
Exp Ther Med. 2015 Jun;9(6):2185-2189.
196.Fan Y, Patima A, Chen Y, Zeng F, He W, Luo L, Jie Y, Zhu Y, Zhang L, Lei J, Xie X, Zhang H.
Cytotoxic effects ofβ-carboline alkaloids on human gastric cancer SGC-7901 cells.
Int J Clin Exp Med. 2015 Aug 15;8(8):12977-82. 
197.Chen X, Wang Y, Liu J, Xu P, Zhang XM, Tian YY, Xue YM, Gao XY, Liu Y, Wang JH.
Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line.
Mol Med Rep. 2015 Sep;12(3):4462-8.
198.Wang J, Zhao YM, Zhang B, Guo CY.
Protective Effect of Total Phenolic Compounds from Inula helenium on Hydrogen Peroxide-induced OxidativeStress in SH-SY5Y Cells.
Indian J Pharm Sci. 2015 Mar-Apr;77(2):163-9.
199.Wang H, Gao X, Lu X, Wang Y, Ma C, Shi Z, Zhu F, He B, Xu C, Sun Y.
The mitotic regulator Hec1 isa critical modulator of prostate cancer throughthe long non-coding RNA BX647187in vitro.
Biosci Rep. 2015 Nov 26;35(6):e00273. 
200.Bai J, Lei Y, An GL, He L.
Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependentmitochondrial pathway.
PLoS One. 2015 Mar 16;10(3):e0121247.
201.Jian-Tao Wu, She-Min Lv, Chun-Hui Lu, Jun Gong,Jian-Bo An.
Effect of 3,3′-Biisofraxidin on Apoptosis of Human Gastric Cancer BGC-823 Cells.
Tropical Journal of Pharmaceutical Research.2015 Oct;14(10):1803.
202.Luo DY, Wazir R, Du C, Tian Y, Yue X, Wei TQ, Wang KJ.
Magnitude-dependent proliferation and contractility modulation of human bladder smoothmusclecells underphysiological stretch.
World J Urol. 2015 Nov;33(11):1881-7.
203.Li K, Dan Z, Nie Y, Hu X, Gesang L, Bianba Z, Ze Y, Ciren C.
CD14 knockdown reduces lipopolysaccharide-induced cellviability and expression of inflammation-associatedgenes in gastriccancer cells invitro andin nude mousexenografts.
Mol Med Rep. 2015 Sep;12(3):4332-9.
204.Nie F, Liu T, Zhong L, Yang X, Liu Y, Xia H, Liu X, Wang X, Liu Z, Zhou L, Mao Z, Zhou Q, Chen T.
MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9.
Mol Med Rep. 2015 Nov;13(1):83-90.
205.Li L, Li X, The E, Wang LJ, Yuan TY, Wang SY, Feng J, Wang J, Liu Y, Wu YH, Ma XE, Ge J, Cui YY, Jiang XY.
Low expression of lncRNA-GAS5 is implicated in human primary varicose great saphenous veins.
PLoS One. 2015 Mar 25;10(3):e0120550.
206.Xia L, Sun C, Li Q, Feng F, Qiao E, Jiang L, Wu B, Ge M.
CELF1 is Up-Regulated in Glioma and Promotes Glioma Cell Proliferation by Suppression of CDKN1B.
Int J Biol Sci. 2015 Sep 22;11(11):1314-24.
207.Xiang XH, Jiang TP, Zhang S, Song J, Li X, Yang JY, Zhou S.
Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagentype I in rat hepatic stellate cells in vitro.
Mol Med Rep. 2015 Jul;12(1):309-14.
208.Wei B, Huang QY, Huang SR, Mai W, Zhong XG.
MicroRNA 34a attenuates the proliferation, invasionand metastasis of gastriccancer cells via downregulation ofMET.
Mol Med Rep. 2015 Oct;12(4):5255-61.
209.Wei C, Xiao Q, Kuang X, Zhang T, Yang Z, Wang L.
Fucoidan inhibits proliferation ofthe SKM-1 acute myeloid leukaemia cell line via the activation of apoptoticpathways and production of reactive oxygen species.
Mol Med Rep. 2015 Nov;12(5):6649-55.
210.Ma J, Guo R, Wang T, Pan X, Lei X.
Let-7b binding site polymorphism inthe B-cell lymphoma-extra large 3'UTR is associated with fluorouracilresistance of hepatocellular carcinoma.
Mol Med Rep. 2015 Jan;11(1):677-81.
211.Liu C, Zhang L, Huang Y, Lu K, Tao T, Chen S, Zhang X, Guan H, Chen M, Xu B.
MicroRNA 328 directly targets p21 activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity.
Mol Med Rep. 2015 Nov;12(5):7389-95.
212.Pang T, Wang S, Gao M, Kang H, Zhao Y, Yao Y, Hu X.
HPV18 E7 induces the over-transcription of eIF4E gene in cervical cancer.
Iran J Basic Med Sci. 2015 Jul;18(7):684-90.
213.Zhang J, Wu D, Vikash, Song J, Wang J, Yi J, Dong W.
Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by IncreasingReactive Oxygen Species.
Dig Dis Sci. 2015 Oct;60(10):2985-95.
214.S Zhang, X Zheng, Y Sun, Y Wang, Z Zhang.
Alterations in oxidative stress and apoptosis in cultured PC12 cells exposed to fluoride.
Research Report Fluoride. 2015 Jul-Sep; 48(3):213-22.
215.Song C, Wang J, Mo C, Mu S, Jiang X, Li X, Zhong S, Zhao Z, Zhou G.
Useof Ferritin Expression, Regulated by Neural Cell-Specific Promoters in Human Adipose Tissue-DerivedMesenchymal Stem Cells, to Monitor Differentiation with Magnetic Resonance Imaging In Vitro.
PLoS One. 2015 Jul 15;10(7):e0132480.
216.Zhang G, Na Z, Ren B, Zhao X, Liu W.
Impacts of fluorescent superparamagnetic iron oxide (SPIO)-labeled materials on biological characteristics andosteogenesis of bone marrow mesenchymal stemcells(BMSCs).
Int J Clin Exp Med. 2015 Aug 15;8(8):12172-81.
217.Xu ZZ, Xiu P, Lv JW, Wang FH, Dong XF, Liu F, Li T, Li J.
Integrin αvβ3is required for cathepsin B-induced hepatocellular carcinoma progression.
Mol Med Rep. 2015 May;11(5):3499-504.
218.Shao XJ, Miao MH, Xue J, Xue J, Ji XQ, Zhu H.
The Down-Regulation of MicroRNA-497 Contributes to Cell Growth and Cisplatin Resistance Through PI3K/AktPathway in Osteosarcoma.
Cell Physiol Biochem. 2015 Jul;36(5):2051-62.
219.Bai X, Meng H, Ma L, Guo A.
Inhibitory effects of evodiamine on human osteosarcoma cell proliferation and apoptosis.
Oncol Lett. 2015 Feb;9(2):801-805.
220.An S, Gao Y, Huang Y, Jiang X, Ma K, Ling J.
Short-term effects of calcium ions onthe apoptosis and onset of mineralization of human dental pulp cells in vitroand in vivo.
Int J Mol Med. 2015 Jul;36(1):215-21.
221.Han Y, Wang H, Huang Y, Cheng Z, Sun T, Chen G, Xie X, Zhou Y, Du Z.
Isolation and characteristics of CD133 /A2B5+and CD133 /A2B5 cells from the SHG139s cell line.
Mol Med Rep. 2015 Dec;12(6):7949-56.
222.Li XR, Yang LZ, Huo XQ, Wang Y, Yang QH, Zhang QQ.
Effects of silencing the ATP-binding cassette protein E1 gene by electroporation onthe proliferation andmigration of EC109 human esophageal cancer cells.
Mol Med Rep. 2015 Jul;12(1):837-42.
223.Wang L, Li X, Liu X, Lu K, Chen NA, Li P, Lv X, Wang X.
Enhancing effects of indirubin onthe arsenic disulfide-induced apoptosis of human diffuse large B-cell lymphomacells.
Oncol Lett. 2015 Apr;9(4):1940-1946.
224.Mei H, Yu L, Ji P, Yang J, Fang S, Guo W, Liu Y, Chen X.
Doxorubicin activates the Notch signaling pathway in osteosarcoma.
Oncol Lett. 2015 Jun;9(6):2905-9.
225.An S, Gao Y, Ling J.
Characterization of human periodontal ligament cells cultured on three-dimensional biphasic calcium phosphate scaffolds in the presence and absence of L-ascorbic acid, dexamethasone and β-glycerophosphate in vitro.
Experimental and Therapeutic Medicine. 2015;10(4): 1387-93.
226.Li F, Xu Y, Chen C, Chen SM, Xiao BK, Tao ZZ.
Pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane in nasopharyngeal carcinoma cells viadownregulation of telomerase activity.
Mol Med Rep. 2015 Sep;12(3):3815-20.
227.Zhou B, Shu B, Xi T, Su N, Liu J.
Dub3 expression correlates with tumor progression and poor prognosis in human epithelial ovarian cancer.
Biomed Pharmacother. 2015 Mar;70:84-9.
228.Zhang Y, Wu H, Zhang M, Jiang Y, Zhuo W, Zhang Y, Hua S.
Nicotinamide induces apoptosis of F9 mouse teratocarcinoma stem cells by downregulation of SATB1expression.
Tumour Biol. 2015 Jun;36(6):4339-48.
229.Piao MX, Bai JW, Zhang PF, Zhang YZ.
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.
Int J Clin Exp Pathol. 2015 Mar 1;8(3):2787-94.
230.Yao J, Zhang YS, Feng GZ, Du Q.
Chrysin inhibits human airway smooth muscle cells proliferation throughthe extracellular signal regulated kinase1/2 signaling pathway.
Mol Med Rep. 2015 Sep;12(5):7693-8.
231.Zhang X, Guo WG, Cui H, Liu HY, Zhang Y, Müller WE, Cui FZ.
In vitro and in vivo enhancement of osteogenic capacity in a synthetic BMP-2 derived peptide-coated mineralizedcollagen composite.
J Tissue Eng Regen Med. 2016 Feb;10(2):99-107.
232.Yang Y, Sun X, Yang Y, Yang X, Zhu H, Dai S, Chen X, Zhang H, Guo Q, Song Y, Wang F, Cheng H, Sun X.
Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygenspecies via targeting Akt/mTOR pathway.
Tumour Biol. 2016 Feb;37(2):1853–62.
233.Zhang Y, Zhi L, Zhang Z. 
Study of the biological features of in vitro cultured γδ T cells.
Biomedical Reports. 2016 Jan;4(1): 87-91.
234.Zhou J, Li W, Guo J, Li G, Chen F, Zhou J.
Downregulation of miR-329 promotes cell invasion by regulating BRD4 and predicts poor prognosis inhepatocellular carcinoma.
Tumour Biol. 2016 Mar;37(3):3561-9.
235.Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N, Zhu R.
Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatomacells. 
Mol Med Rep. 2016 Jul;14(1):159-64.
236.Xia P, Chen HY, Chen SF, Wang L, Strappe PM, Yang HL, Zhou CH, Zhang X, Zhang YX, Ma LL, Wang L.
The stimulatory effects of eNOS/F92A-Cav1 on NO production and angiogenesis in BMSCs.
Biomed Pharmacother. 2016 Feb;77:7-13.
237.Wu YH, Ai X, Liu FY, Liang HF, Zhang BX, Chen XP.
c-Jun N-terminal kinase inhibitor favors transforming growth factor-β to antagonize hepatitis B virus Xprotein-induced cell growth promotion in hepatocellular carcinoma.
Mol Med Rep. 2016 Feb;13(2):1345-52.
238.Dai J, Sun C, Yao Z, Chen W, Yu L, Long M.
Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrierfunction via the IL-6/HIF-1α signaling pathway.
FEBS Open Bio. 2016 May 24;6(7):720-8.
239.Xu L, Liao WL, Lu QJ, Li CG, Yuan Y, Xu ZY, Huang SD, Chen HZ.
ANG Promotes Proliferation and Invasion of the Cell of Lung Squamous Carcinoma by Directly Up-Regulating HMGA2. 
J Cancer. 2016 Apr 28;7(7):862-71.
240.Tu P, Huang Q, Ou Y, Du X, Li K, Tao Y, Yin H.
Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcomacell line MG 63 through the ROS/JNK signaling pathway. 
Oncol Rep. 2016 Jun;35(6):3209-15.
241.Chen H, Wu G, Sun Q, Dong Y, Zhao H.
Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1β-induced apoptosisvia the PI3K/AKT signaling pathway.
Am J Transl Res. 2016 Nov 15;8(11):5108-5117.
242.Li RL, Lu ZY, Huang JJ, Qi J, Hu A, Su ZX, Zhang L, Li Y, Shi YQ, Hao CN, Duan JL.
SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium. 
Am J Transl Res. 2016 Jul 15;8(7):2876-88.
243.Sun J, Jiang J, Lu K, Chen Q, Tao D, Chen Z.
Therapeutic potential of ADAM17 modulation in gastric cancer through regulation of the EGFR and TNF-α signalling pathways. 
Mol Cell Biochem. 2016 Nov 22. [Epub ahead of print]
244.Peng Z, Ouyang T, Pang D, Ma T, Chen X, Guo N, Chen F, Yuan L, Ouyang H, Ren L.
Pseudorabies virus can escape from CRISPR-Cas9-mediated inhibition. 
Virus Res. 2016 Sep 2;223:197-205.
245.Chen J, Wu FX, Luo HL, Liu JJ, Luo T, Bai T, Li LQ, Fan XH. 
Berberine upregulates miR-22-3p to suppress hepatocellular carcinoma cell proliferation by targetingSp1.
Am J Transl Res. 2016 Nov 15;8(11):4932-4941. 
246.Yang Y, Sun X, Yang Y, Yang X, Zhu H, Dai S, Chen X, Zhang H, Guo Q, Song Y, Wang F, Cheng H, Sun X.
Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactiveoxygen species via targeting Akt/mTOR pathway. 
Tumour Biol. 2016 Feb;37(2):1853-62.
247.Shi Z, Wu D, Tang R, Li X, Chen R, Xue S, Zhang C, Sun X.
Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells.
J Biosci. 2016 Jun;41(2):229-36.
248.Liu C, Chen Z, Fang J, Xu A, Zhang W, Wang Z.
H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation.
Tumour Biol. 2016 Jan;37(1):263-70.
249.Zhu Y, Zhao H, Feng L, Xu S.
MicroRNA-217 inhibits cell proliferation and invasion by targeting Runx2 in human glioma.
Am J Transl Res. 2016 Mar 15;8(3):1482-91.
250.Han Y, Wu Z, Wu T, Huang Y, Cheng Z, Li X, Sun T, Xie X, Zhou Y, Du Z.
Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2and inactivation of ERK/MAPK signaling. 
Cell Death Dis. 2016 Mar 3;7:e2123.
251.Zhang X, Tang S, Zhang Q, Shao W, Han X, Wang Y, Du Y.
Endoplasmic reticulum stress mediates JNK-dependent IRS-1 serine phosphorylation and results in Tauhyperphosphorylation in amyloid β oligomer-treated PC12 cells and primary neurons. 
Gene. 2016 Aug 10;587(2):183-93.
252.Yang D, Jiang T, Lin P, Chen H, Wang L, Wang N, Zhao F, Wang A, Jin Y.
Knock-down of apoptosis inducing factor gene protects endoplasmic reticulum stress-mediated goatgranulosa cell apoptosis. 
Theriogenology. 2017 Jan 15;88:89-97. 
253.Ma T, Ouyang T, Ouyang H, Chen F, Peng Z, Chen X, Pang D, Ren L.
Porcine circovirus 2 proliferation can be enhanced by stably expressing porcine IL-2 gene in PK-15 cell. 
Virus Res. 2017 Jan 2;227:143-149.
254.Yue H, Zhu J, Xie S, Li F, Xu Q.
MDC1-AS, an antisense long noncoding RNA, regulates cell proliferation of glioma.
Biomed Pharmacother. 2017 Feb;426(1-2):17-26.