碧云天生物技术-AICAR (AMPK激活剂, >99%)(S1515-50mg)

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AICAR (AMPK激活剂, >99%)

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产品编号: S1515-50mg

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产品编号	产品名称	产品包装	产品价格
S1515-5mg	AICAR (AMPK激活剂, >99%)	5mg	125.00元
S1515-50mg	AICAR (AMPK激活剂, >99%)	50mg	1027.00元

AICAR，全称为5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside，也称AICA Riboside或Acadesine，是一种可通透细胞膜AMP-activated protein kinase(AMPK)的激活剂。AMPK是代谢调控的关键蛋白，当能量供应不足时，AMP/ATP的比率上调，AMPK就会被激活，抑制合成代谢。AICAR可以激活AMPK，但不影响ATP、ADP和AMP的水平。在细胞或动物水平，AICAR可以通过激活AMPK从而促进骨骼肌非胰岛素依赖的葡萄糖摄入。AICAR诱导的骨骼肌葡萄糖摄入不能被PI3K的抑制剂所阻断。
AICAR分子量为258.23，分子式为C₉H₁₄N₄O₅，CAS Number：2627-69-2。本产品为进口分装，纯度大于99%。可溶于DMSO(20mg/ml)，甲醇(10mg/ml)，乙醇(1mg/ml)，水(>7mg/ml)和二甲基甲酰胺，在PBS中的溶解度约为0.3mg/ml。
AICAR配制于水性溶液中后建议立即使用。配制在DMSO等有机溶剂中的AICAR可在-20℃保存长达3个月。
包装清单：

产品编号	产品名称	包装
S1515-5mg	AICAR (AMPK激活剂, >99%)	5mg
S1515-50mg	AICAR (AMPK激活剂, >99%)	50mg
—	说明书	1份

保存条件：
-20℃保存。
注意事项：
本产品对人体有刺激性，操作时请小心，并注意适当防护以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1.AICAR常见使用浓度范围为0.5-5mM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。

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AMPK Signaling

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Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memorypreservation.

Nat Neurosci. 2017 May;20(5):690-699. (IF 20.071)

2. Xie N, Yuan K, Zhou L, Wang K, Chen HN, Lei Y, Lan J, Pu Q, Gao W, Zhang L, Shen G, Li Q, Xiao H, Tang H, Xiang R, He M, Feng P, Nice EC10, Wei Y, Zhang H, Yang J1, Huang C.

PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation.

Autophagy. 2016 Sep;12(9):1507-20. (IF 9.77)

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2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis

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4. Wang M, Gao X, Zhao W, Zhao W, Jiang S, Huang F, Kou J, Liu B, Liu K.

Opposite effects of genistein on regulation of insulin-mediated glucose homeostasis in adipose tissue.

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5. Li X, Li J, Wang L, Li A, Qiu Z, Qi LW, Kou J, Liu K, Liu B, Huang F.

The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation andfibrosis in hypoxic adipose tissue.

BRIT J PHARMACOL. 2016 Jun;173(12):2001-15. (IF 7.73)

6. Song J, Li J, Hou F, Wang X, Liu B.

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells.

Metabolism. 2015 Mar;64(3):428-37. (IF 6.159)

7. Sun Y, Li J, Xiao N, Wang M, Kou J, Qi L, Huang F, Liu B, Liu K.

Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.

Pharmacol Res. 2014 Nov;89:19-28. (IF 5.893)

8. Bai T, Yang Y, Yao YL, Sun P, Lian LH, Wu YL, Nan JX.

Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway.

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9. Zhu Z, Li R, Ma G, Bai W, Fan X, Lv Y, Luo J, Zeng W

5'-AMP-Activated Protein Kinase Regulates Goat Sperm Functions via Energy Metabolism In Vitro.

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10. Xu M, Hu J, Zhao W, Gao X, Jiang C, Liu K, Liu B, Huang F.

Quercetin differently regulates insulin-mediated glucose transporter 4 translocation under basal and inflammatory conditions in adipocytes.

Mol Nutr Food Res. 2014 May;58(5):931-41. (IF 5.309)

11. Liu K, Mei F, Wang Y, Xiao N, Yang L, Wang Y, Li J, Huang F, Kou J, Liu B, Qi LW.

Quercetin oppositely regulates insulin-mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation.

Mol Nutr Food Res. 2016 Mar;60(3):551-65. (IF 5.309)

12. Zhang B, Guo X, Li Y, Peng Q, Gao J, Liu B, Wang M.

d-chiro inositol ameliorates endothelial dysfunction via inhibition of oxidative stress and mitochondrialfission.

Mol Nutr Food Res. 2017 Jan 14.doi: 10.1002/mnfr.201600710. [Epub ahead of print] (IF 5.309)

13. Zhang B, Guo X, Li Y, Peng Q, Gao J, Liu B, Wang M.

d-Chiro inositol ameliorates endothelial dysfunction via inhibition of oxidative stress and mitochondrial fission.

Mol Nutr Food Res. 2017 Aug;61(8). (IF 5.309)

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AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin.

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15. Miao XY, Gu ZY, Liu P, Hu Y, Li L, Gong YP, Shu H, Liu Y, Li CL.

The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway.

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16. Zhao Q, Sun Y, Ji Y, Xu L, Liu K, Liu B, Huang F.

Total polyphenol of Anemarrhena asphodeloides ameliorates advanced glycation end products-induced endothelial dysfunction by regulation of AMP-Kinase.

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17. Shi X, YongyanWu, Ai Z, Du J, Cao L, Guo Z, Zhang Y.

MicroRNA modulation induced by AICA ribonucleotide in J1 mouse ES cells.

PLoS One. 2014 Jul 31;9(7):e103724. (IF 2.74)

18. Wu J, Xu X, Li Y, Kou J, Huang F, Liu B, Liu K.

Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells.

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19. Lu J, Cao Y, Cheng K, Xu B, Wang T, Yang Q, Yang Q, Feng X, Xia Q.

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Exp Cell Res. 2015 Jun 10;334(2):194-206. (IF 3.383)

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21. Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P.

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