“服务生命科学，造福人民健康“，碧云天自成立之日起就秉承这一愿景！
2021年，是碧云天成立20周年，我们特别推出了碧云天启明星奖(Beyotime Rising-Star Award)，奖项总金额为20万元，旨在表彰优秀国内青年科学家，激发青年科研人员的积极性，促进优秀青年科学家成长为未来学术带头人，从而更好地推进中国生命科学研究的发展。
国内的许多优秀青年科学家向我们提交了申请，经过持续近一年的收集整理，并严格按照活动要求遴选，最终约200名申请人通过了初步的资格审查。本着公开、公平、公正的原则，我们聘请了数位国内生命科学领域的专家，通过专业评审和投票，评选出最终获奖人。
碧云天启明星奖奖项设置如下：

碧云天启明星拟获奖名单公示如下：

奖项名称	姓名	单位	主要研究成果
			论文题目	论文期刊	卷期页
卓越启明星奖	刘家栋	中国科学院广州生物医药与健康研究院	The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity	Nature	2021；591(7849)：322-326
卓越启明星奖	申龙	天津医科大学	Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation	Cell Metabolism	2021；33(5)：971-987
卓越启明星奖	谢煜骅	北京生命科学研究所	Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	Cell Stem Cell	2022；29( 1)： 1-16

奖项名称	姓名	单位	主要研究成果
			论文题目	论文期刊	卷期页
杰出启明星奖	吕洪伟	海军军医大学国家肝癌科学中心	NAD + Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	Cell Metabolism	2021；33( 1)： 110-127.e5
杰出启明星奖	王怡飞	南方医科大学	The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis	Nature Immunology	2022；23：303–317
杰出启明星奖	魏刚	上海交通大学	The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	Cell Metabolism	2021；33（10）：2021-2039e8
杰出启明星奖	朱志荣	华东理工大学	An Enzyme-Activatable Aggregation-Induced-Emission Probe: Intraoperative Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E	Advanced Materials	2021；34(3)：2107444
			Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-sensitive potassium (KATP)	National Science Review	2021；8(6)：28-39
杰出启明星奖	刘沛鑫	复旦大学	Biomimetic Dendrimer–Peptide Conjugates for Early Multi-Target Therapy of Alzheimer’s Disease by Inflammatory Microenvironment Modulation	Advanced Materials	2021；33（26）：2100746

奖项名称	姓名	单位	主要研究成果
			论文题目	论文期刊	卷期页
优秀启明星奖	柳思扬	中山大学	Ultrathin 2D Copper(I) 1,2,4-Triazolate Coordination Polymer Nanosheets for Efficient and Selective Gene Silencing and Photodynamic Therapy	Advanced Materials	2021；33（18）：2100849
优秀启明星奖	王晖	南开大学	Recognition and Removal of Amyloid-β by a Heteromultivalent Macrocyclic Coassembly: A Potential Strategy for the Treatment of Alzheimer’s Disease	Advanced Materials	2021；33（4）：2006483
优秀启明星奖	杨宜锜	上海交通大学医学院附属第九人民医院	Ubiquitination Flow Repressors: Enhancing Wound Healing of Infectious Diabetic Ulcers through Stabilization of Polyubiquitinated Hypoxia-Inducible Factor-1α by Theranostic Nitric Oxide Nanogenerators	Advanced Materials	2021；33（45）：2103593
优秀启明星奖	周春宇	陆军军医大学	Activatable NIR-II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy	Advanced Materials	2021；33（3）：2006532.1-2006532.11
优秀启明星奖	谢枫	苏州大学	Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy	Advanced Materials	2021：33（49）：2103471
优秀启明星奖	王韵婧	清华大学	A calmodulin-binding transcription factor links calcium signaling to antiviral RNAi defense in plants	Cell Host&Microbe	2021；29（9）：1393-1406.e7
优秀启明星奖	汪文锦	中山大学	Induction and Monitoring of DNA Phase Separation in Living Cells by a Light-Switching Ruthenium Complex	Journal of the American Chemical Society	2021；143,（30 ）：11370–11381
			Ferroptosis-Enhanced Cancer Immunity by a Ferrocene-Appended Iridium(III) Diphosphine Complex	Angewandte Chemie	2022；61（16）：e202115247
优秀启明星奖	李艳艳	四川大学	Nanozyme-Based Stretchable Hydrogel of Low Hysteresis with Antibacterial and Antioxidant Dual Functions for Closely Fitting and Wound Healing in Movable Parts	Advanced Functional Materials	2022；32（13）：2110720
			Ultra-Stretchable, Variable Modulus, Shape Memory Multi-Purpose Low Hysteresis Hydrogel Derived from Solvent-Induced Dynamic Micelle Sea-Island Structure	Advanced Functional Materials	2021；31(22)：2011259
			Chemically Grafted Nanozyme Composite Cryogels to Enhance Antibacterial and Biocompatible Performance for Bioliquid Regulation and Adaptive Bacteria Trapping	ACS Nano	2021； 15（12）：19672–19683
优秀启明星奖	李洁	中国药科大学	Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulation of bile acid metabolism	Journal of Hepatology	2021；75（2）： 400-413
优秀启明星奖	张可人	上海交通大学	Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer	Science Translational Medicine	2021 ；13(614)：1-16
优秀启明星奖	冯炜	上海大学	2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases	Nature Communications	2021 ；12(1)：2203
优秀启明星奖	李自豪	武汉大学	Ultra-small FePt/siRNA loaded mesoporous silica nanoplatform to deplete cysteine for enhanced ferroptosis in breast tumor therapy	Nano Today	2021；38： 101150
			Platinum-Doped Prussian Blue Nanozymes for Multiwavelength Bioimaging Guided Photothermal Therapy of Tumor and Anti-Inflammation	ACS Nano	2021； 15（3）：5189–5200

奖项名称	姓名	单位	主要研究成果
			论文题目	论文期刊	卷期页
启明星奖	邓彩凤	中南大学湘雅医院	Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis	Nature Communications	2021；12：2174
启明星奖	尚曼	天津医科大学	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation	Nature Communications	2021，12：1940
启明星奖	丁仁博	海南大学	Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics	Nature Communications	2021；12： 3046
启明星奖	沈俊	中国医学科学院血液学研究所	Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs	Science Advances	2021；7（36）
启明星奖	曾伟伟	中山大学	Renal-Clearable Ultrasmall Polypyrrole Nanoparticles with Size-Regulated Property for Second Near-Infrared Light-Mediated Photothermal Therapy	Advanced Functional Materials	2021，31(15)：2008362
启明星奖	刘桂君	上海营养与健康研究所	Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis	Hepatology	2021；74（6）：3037-3055
启明星奖	杨磊	南京大学	Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN	Journal of Hematology & Oncology	2021； 14： 46
启明星奖	姬丹阳	香港城市大学	Circular L-RNA aptamer promotes target recognition and controls gene activity	Nucleic Acids Research	2021；49（31）：7280–7291
			Discovery of G-quadruplex-forming sequences in SARS-CoV-2	Briefings in bioinformatics	2021；22(2) : 1150–1160
启明星奖	贾瑞瑞	重庆大学	Gawky modulates MTF-1-mediated transcription activation and metal discrimination.	Nucleic Acids Research	2021；49（11）：6296–6314,
启明星奖	江天彤妃	哈尔滨医科大学	ImmReg: the regulon atlas of immune-related pathways across cancer types	Nucleic Acids Research	2021；49(21）：12106-12118
启明星奖	宋振兴	重庆大学	Gawky modulates MTF-1-mediated transcription activation and metal discrimination	Nucleic Acids Research	2021； 49（11）： 6296–6314,
启明星奖	刘起东	同济大学	Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABAAR-Dependent TRIM21 Modulation of Src Expression	Advanced Science	2021；8（18）2102079
启明星奖	孙娴	中科院上海药物研究所	Multiscale Co‐reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution	Advanced Science	2021；8（8）：2003941
启明星奖	林建立	北京大学	Cross-reactive antibodies against dust mite-derived enolase induce neutrophilic airway inflammation.	European Respiratory Journal	2021 ；57：1902375
启明星奖	陈亚冰	南京大学	m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells	Autophagy	2021 ；17（2）： 457-475
			Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells	Theranostics	2021；11(16)：7640-7657
启明星奖	刘佳俊	浙江大学	Increased alveolar epithelial TRAF6 via autophagy dependent TRIM37 degradation mediates particulate matter induced lung metastasis	Autophagy	2022；18（4）
启明星奖	李惟芬	北京大学深圳研究生院	Anti-depressive-like behaviors of APN KO mice involve Trkb/ BDNF signaling related neuroinflammatory changes	Molecular Psychiatry	Molecular Psychiatry (2021)
启明星奖	廖志伟	华中科技大学同济医学院附属协和医院	Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration	ACS Nano	2021；15(9)：14709-14724
			Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration	Biomaterials	2021；274：120850
启明星奖	赵梦	四川大学	Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial dysfunction and inflammation by restoring TFAM signaling and stabilizing mitochondrial DNA	ACS Nano	2021；15（1）： 1519–1538
			Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance	Theranostics	2021 ；11(4)：1845-1863.
启明星奖	陈归	南方医科大学	Glutamine Antagonist Synergizes with Electrodynamic Therapy to Induce Tumor Regression and Systemic Antitumor Immunity	ACS Nano	2022；16（1）：951–962
启明星奖	陈迪	中科院生物物理研究所	ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress	Developmental Cell	2021；56（23）3250-3263.e5
启明星奖	张艳文	湖南大学	Giant Coacervate Vesicles As an Integrated Approach toCytomimetic Modeling	Journal of the American Chemical Society	2021；143(7)：2866-2874.
启明星奖	张秋玲	武汉大学	A Strategy Based on the Enzyme-Catalyzed Polymerization Reaction of Asp-Phe-Tyr Tripeptide for Cancer Immunotherapy	Journal of the American Chemical Society	2021, 143, 13, 5127–5140
启明星奖	张家恒	湖南大学	Development of Near-Infrared Nucleic Acid Mimics of Fluorescent Proteins for In Vivo Imaging of Viral RNA with Turn-On Fluorescence	Journal of the American Chemical Society	2021, 143, 46, 19317–19329
启明星奖	苏绪贤	中山大学	A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity	Angewandte Chemie-Internation Edition	2022；61（8）：e202115800
启明星奖	马春梅	南京医科大学	AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis	Jorunal of experiment medicine	2021；218（5)：e202115800
启明星奖	王卫云	浙江大学	Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production	The EMBO Journal	2021；40（11）： e106771
启明星奖	王旭	复旦大学	SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade	The EMBO Journal	2021；40（24）：e108080
启明星奖	陈欣欣	中科院生物物理研究所	Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization	Proceedings of the National Academy of Sciences of the United States of America	2021；60（49）： 25865-25871
启明星奖	张学瑞	南京大学	Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy	Signal Transduction and Targeted Therapy	2021；6(1)：235

奖项名称	姓名	单位	主要研究成果
			论文题目	论文期刊	卷期页
入围奖	王雪儿	山东大学	TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity	Singal Transduction and Targeted Therapy	2021 ；6(1)：298
入围奖	陈徐	陕西师范大学	SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis	Cell Death and Differentiation	2022；29：337–350
入围奖	王晓刚	华东理工大学	Calcium phosphate-based materials regulate osteoclast-mediated osseointegration	Bioactive Materials	2021；6：4517-4530
入围奖	薛松	安徽医科大学第一附属医院	Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy	Bioactive Materials	2021；8（6）： 2372-2389
入围奖	谢西月	重庆大学	Redox Host–Guest Nanosensors Installed with DNA Gatekeepers for Immobilization-Free and Ratiometric Electrochemical Detection of miRNA	Small Methods	2021，5（12）：2101072
入围奖	叶军	中国医学科学院&北京协和医学院药物研究所	Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity	Journal for ImmunoTherapy of Cancer	2021；9（7）：002753
			Comparative colloidal stability, antitumor efficacy, and immunosuppressive effect of commercial paclitaxel nanoformulations	Journal of Nanobiotechnology	2021，19（199 ）
入围奖	周露露	同济大学	Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferropotosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent in Situ Bleomycin Toxification	Small	2021；17(47)：2103919
			A Self-Amplified Nanocatalytic System for Achieving "1+1+1>3" Chemodynamic Therapy on Triple Negative Breast Cancer	Journal of Nanobiotechnology	2021：19(261)
入围奖	陈伟	上海交通大学医学院附属瑞金医院	Electrospun Fibers Improving Cellular Respiration via Mitochondrial Protection	Small	2021；17(46)：2104012
入围奖	李伊特	长春应化所	Ionic Covalent-Organic Framework Nanozyme as Effective Cascade Catalyst against Bacterial Wound Infection	Small	2021；17(32) ：2100756:
入围奖	安佳	南方科技大学	Multichannel ratiometric fluorescence sensor arrays for rapid visual monitoring of epinephrine, norepinephrine, and levodopa	Chemical Engineering Journal	2021；425： 130595
入围奖	郑丹丹	上海交通大学医学院附属仁济医院	Metformin-hydrogel with glucose responsiveness for chronic inflammatory suppression	Chemical Engineering Journal	2022；428： 131064
入围奖	陶白龙	重庆医科大学	Osteoimmunomodulation mediating improved osteointegration by OGP-loaded cobalt-metal organic framework on titanium implants with antibacterial property	Chemical Engineering Journal	2021；423：130176
			Near infrared light-triggered on-demand Cur release from Gel-PDA@Cur composite hydrogel for antibacterial wound healing	Chemical Engineering Journal	2021, 403：126182-1-126182-15
入围奖	俎梦航	西南大学	‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases	Biomaterials	2021；279： 121178
入围奖	潘建安	上海交通大学医学院附属第九人民医院	Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells	Redox Biology	2021；46 ：10212:
入围奖	刘金鑫	江南大学	Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4	Theranostics	2021；11(17)：8283-8300.
入围奖	王亦梁	暨南大学	A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection	Theranostics	2021；11(19)：9623-9651
入围奖	鲁荐	南京大学医学院附属鼓楼医院	GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity	Theranostics	2021；11(10)：4728-4742
入围奖	汪祖利	中南大学肿瘤研究所	A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis	Molecular Therapy	2021；29（1）： 263-274
入围奖	杜希良	吉林大学	Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway	Acta Pharmaceutica Sinica B	2021；11（12）： 3683-4054
入围奖	文玉	中南大学	Real-Time Intraoperative Surface-Enhanced Raman Spectroscopy-Guided Thermosurgical Eradication of Residual Microtumors in Orthotopic Breast Cancer	Nano Letters	2021； 21（7）： 3066–3074
入围奖	张睿佳	中山大学	Non-targeted metabolomics of multiple human cells revealing differential toxic effects of perfluorooctanoic acid	Journal of Hazardous Materials	2021；409： 125017
入围奖	郝颖	河北医科大学	Effects of chronic triclosan exposure on social behaviors in adult mice	Journal of Hazardous Materials	2022；424，127562
入围奖	吴雨昊	重庆医科大学附属儿童医院	Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes	Journal of Hazardous Materials	2022；426（15）：127807
入围奖	蔡序子	南方医科大学	Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy	Journal of Nanobiotechnology	2021；19：254
入围奖	李丘轲	东北农业大学	De novo design of a pH-triggered self-assembled β-hairpin nanopeptide with the dual biological functions for antibacterial and entrapment	Journal of Nanobiotechnology	2021；19:183
入围奖	赵建龙	中国农业科学院蔬菜花卉研究所	A Meloidogyne incognita C‐type lectin effector targets plant catalases to promote parasitism	New Phytologist	2021；232（5）：2124-2137
入围奖	易兵成	上海市第九人民医院	Lysine-doped polydopamine coating enhances antithrombogenicity and endothelialization of an electrospun aligned fibrous vascular graft	Applied Materials Today	2021；25： 101198
入围奖	裴晴	中国科学院长春应用化学研究所	Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy	ACS Applied Materials & Interfaces	2021；13（50）：59708–59719

注：按照活动规则，参选人员须作为第一作者，以非独立PI身份在2021年度正式或在线发表具有突破意义或重要原创性的、且主要研究工作在国内完成的研究成果。上述表格仅列举了获奖人部分主要科研成果；如您对获奖名单有任何异议，请在名单公布后7个工作日内，发送邮件至 marketing@beyotime.com或通过公众号、QQ等联系我们在线客服。

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