碧云天生物技术-Rhodamine 123(Rhodamine 123荧光染料)(C2007)

试剂> 细胞相关> 细胞组织染色> 荧光染色

Rhodamine 123

一键复制产品信息

产品编号: C2007

产品包装:5mg

选择包装

5mg

数

量

说明书下载

价格: ¥ 279.00

加入购物车

				产品简介
			
				使用说明
			
				产品文件
			
				相关产品
			
				相关论文
			
				产品问答

产品编号	产品名称	产品包装	产品价格
C2007	Rhodamine 123	5mg	279.00元

Rhodamine 123也称2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester，中文名为罗丹明123，分子式为C₂₁H₁₇ClN₂O₃，分子量为380.82，CAS Number 62669-70-9，纯度>95%。
Rhodamine 123是一种可以通透细胞膜的选择性染色活细胞线粒体的阳离子黄绿色荧光染料，广泛用作检测线粒体膜电位(mitochondrial membrane potential)的荧光探针，也常用于细胞凋亡检测。在正常细胞中，Rhodamine 123能够依赖线粒体跨膜电位(mitochondrial transmembrane potential, ΔΨm)选择性进入线粒体基质，可发出明亮的黄绿色荧光；当细胞发生凋亡或坏死时，线粒体膜电位丢失，线粒体通透性转换孔(mitochondrial permeability transition pore, MPTP)持续开放，引起线粒体跨膜电位(ΔΨm)的崩溃，Rhodamine 123从线粒体中释放出来，从而导致线粒体内黄绿色荧光强度的明显降低。此外有报道，在个别特定情况下，Rhodamine 123探针在线粒体内过度聚集后可能会出现自发淬灭(self-quenching)现象，线粒体内黄绿色荧光强度降低，而在凋亡发生时，线粒体中黄绿色荧光增强。使用本产品，按照说明中推荐的实验条件，对于实际测试过的细胞仅观察到了凋亡或坏死时Rhodamine 123的荧光染色减弱或消失的现象。本产品染色后，可用荧光显微镜、流式细胞仪或其它荧光检测设备检测，通过荧光信号的强弱来确定线粒体膜电位的变化和凋亡的发生。
Rhodamine 123可以快速通过细胞膜，仅需几分钟就可以被具有活性的线粒体所俘获(sequestered by active
mitochondria)，并且对细胞没有任何毒性。
Rhodamine 123的激发光谱和发射光谱参考下图，最大激发波长为507nm，最大发射波长为529nm。在荧光显微镜下观
察，呈现黄绿色荧光。

Rhodamine 123为红棕色粉末，溶于DMSO，也溶于乙醇，在乙醇中的溶解度可达20mg/ml。
包装清单：

产品编号	产品名称	包装
C2007	Rhodamine 123	5mg
—	说明书	1份

保存条件：
室温避光保存，两年有效。溶于DMSO配制成母液后-20℃保存。
注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作

使用说明：
可以先配制1-5mM的母液。使用时通常使Rhodamine 123的终浓度为1-2μM即可。详细的使用方法请参考相关文献资料。

物质安全数据单

输入右侧验证码点击下载：

下载

质检证书

输入批号搜寻COA

搜索

相关产品请点击如下按钮：

荧光染色

线粒体

细胞凋亡荧光探针

细胞器荧光探针

使用本产品的文献：

1. Xiao-Yan Fan, Lei Guo, Lei-Ning Chen, Shen Yin, Jiarong Wen, Sen Li, Jun-Yu Ma, Tao Jing, Man-Xi Jiang, Xiao-Hong Sun, Meilan Chen, Feng Wang, Zhen-Bo Wang, Chang-Fa Zhang, Xing-Hua Wang, Zhao-Jia Ge, Chun Hu, Lizhang Zeng, Wei Shen, Qing-Yuan Sun, Xiang-Hong Ou, Shi-Ming Luo

Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy

Nat Biomed Eng. 2022 Apr;6(4):339-350. doi: 10.1038/s41551-022-00881-7. (IF 18.952)

2. Ju C, Wen Y, Zhang L, Wang Q, Xue L, Shen J, Zhang C

Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer.

Small. 2019 Feb;15(5):e1804191. (IF 11.459)

3. Liu Y, Zhang X, Zhou M, Nan X, Chen X, Zhang X.

Mitochondrial-Targeting Lonidamine-Doxorubicin Nanoparticles for Synergistic Chemotherapy to Conquer Drug Resistance.

ACS APPL MATER INTER. 2017 Dec 20;9(50):43498-43507. (IF 8.758)

4. Yumei Li, Fan Chen, Weiyu Shen, Bifei Li, Rong Xiang, Lijuan Qu, Chen Zhang, Gao Li, Huanzhang Xie, Vladimir L Katanaev, Lee Jia

WDR74 induces nuclear β-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis

Cancer Lett. 2020 Feb 28;471:103-115. doi: 10.1016/j.canlet.2019.12.011. (IF 7.36)

5. Yun Wang, Jia-Huan Lu, Feng Wang, Ying-Nan Wang, Ming-Ming He, Qi-Nian Wu, Yun-Xin Lu, Hong-En Yu, Zhan-Hong Chen, Qi Zhao, Jia Liu, Yan-Xing Chen, De-Shen Wang, Hui Sheng, Ze-Xian Liu, Zhao-Lei Zeng, Rui-Hua Xu, Huai-Qiang Ju

Inhibition of fatty acid catabolism augments the efficacy of oxaliplatin-based chemotherapy in gastrointestinal cancers

Cancer Lett. 2020 Mar 31;473:74-89. doi: 10.1016/j.canlet.2019.12.036. (IF 7.36)

6. Hao M, Kong C, Jiang C, Hou R, Zhao X, Li J, Wang Y, Gao Y, Zhang H, Yang B, Jiang J

Polydopamine-coated Au-Ag nanoparticle-guided photothermal colorectal cancer therapy through multiple cell death pathways.

Acta Biomater. 2019 Jan 1 83:414-424. (IF 7.242)

7. Huo M, Fu Y, Liu Y, Chen Q, Mu Y, Zhou J, Li L, Xu W, Yin T

N-mercapto acetyl-N'-octyl-O, N″-glycol chitosan as an efficiency oral delivery system of paclitaxel.

CARBOHYD POLYM. 2018 Feb 1;181:477-488. (IF 7.182)

8. Kong J, Zhang Y, Ju J, Xie Y, Guo Y, Cheng Y, Qian H, Quek SY, Yao W

Antifungal effects of thymol and salicylic acid on cell membrane and mitochondria of Rhizopus stolonifer and their application in postharvest preservation of tomatoes.

Food Chem. 2019 Jul 1 285:380-388. (IF 6.306)

9. Shuya Gao, Qingchen Yang, Yue Peng, Weixian Kong, Zekun Liu, Zhe Li, Jiawen Chen, Mengmeng Bao, Xie Li, Yubin Zhang, Xiaohong Bian, Liang Jin, Hanwen Zhang, Yuexin Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye

SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart

Cell Biol Toxicol. 2023 Aug;39(4):1489-1507. doi: 10.1007/s10565-022-09735-z. (IF 6.284)

10. Yang Q, Sun G, Yin H, Li H, Cao Z, Wang J, Zhou M, Wang H, Li J

PINK1 Protects Auditory Hair Cells and Spiral Ganglion Neurons from Cisplatin-induced Ototoxicity via Inducing Autophagy and Inhibiting JNK Signaling Pathway.

FREE RADICAL BIO MED. 2018 May 20;120:342-355. (IF 6.17)

11. Wang Y, Zhao X, Gao X, Nie X, Yang Y, Fan X.

Development of fluorescence imaging-based assay for screening cardioprotective compoundsfrom medicinal plants.

Anal Chim Acta. 2011 Sep 19;702(1):87-94. (IF 5.977)

12. Tao Huang, Ying Huang, Yu Huang, Yi Yang, Yuanhui Zhao, Christopher J Martyniuk

Toxicity assessment of the herbicide acetochlor in the human liver carcinoma (HepG2) cell line

Chemosphere. 2020 Mar;243:125345. doi: 10.1016/j.chemosphere.2019.125345. (IF 5.778)

13. Yi JM, Huan XJ, Song SS, Zhou H, Wang YQ, Miao ZH.

Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB orp44.

Mol Cancer Ther. 2016 Jul;15(7):1495-503. (IF 5.615)

14. Zhu X, Lu X

MiR-423-5p inhibition alleviates cardiomyocyte apoptosis and mitochondrial dysfunction caused by hypoxia/reoxygenation through activation of the wnt/β-catenin signaling pathway via targeting MYBL2.

J Cell Physiol. 2019 Dec 234(12):22034-22043. (IF 5.546)

15. Liu X, Liu C, Shan K, Zhang S, Lu Y, Yan B, Luo Y

Long Non-Coding RNA H19 Regulates Human Lens Epithelial Cells Function.

CELL PHYSIOL BIOCHEM. 2018;50(1):246-260. (IF 5.5)

16. Tan Q, Li Y, Wu J, Mei H, Zhao C, Zhang J.

An optimized molecular inclusion complex of diferuloylmethane: enhanced physical properties and biologicalactivity.

INT J NANOMED. 2012;5:5385-93. (IF 5.115)

17. Li X, Yao L, Liang Q, Qu H, Cai H

Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling.

Oxid Med Cell Longev. 2018 Jun 26;2018:1725191. (IF 5.076)

18. Guo S, Wang J, Xu H, Rong W, Gao C, Yuan Z, Xie F, Bi K, Zhang Z, Li Q

Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.

Oxid Med Cell Longev. 2019 Jul 1 2019:9096409. (IF 5.076)

19. Li BY, Yuan YH, Hu JF, Zhao Q, Zhang DM, Chen NH.

Protective effect of Bu-7, a flavonoid extracted from Clausena lansium, against rotenone injury inPC12 cells.

Acta Pharmacol Sin. 2011 Nov;32(11):1321-6. (IF 5.064)

20. Wang M, Ruan Y, Chen Q, Li S, Wang Q, Cai J

Curcumin induced HepG2 cell apoptosis-associated mitochondrial membrane potential and intracellular free Ca(2+) concentration.

Eur J Pharmacol. 2011 Jan 10;650(1):41-7. (IF 3.263)

21. Yan C, Huang D, Zhang Y.

The involvement of ROS overproduction and mitochondrial dysfunction in PBDE-47-induced apoptosis on Jurkat cells.

EXP TOXICOL PATHOL. 2011 Jul;63(5):413-7. (IF 2.023)

22. Zhang WL, Zhao YL, Liu XM, Chen J, Zhang D

Protective role of mitochondrial K-ATP channel and mitochondrial membrane transport pore in ratkidney ischemic postconditioning.

CHINESE MED J-PEKING. 2011 Jul;124(14):2191-5. (IF 1.585)

23. Gao W, Xu K, Ji L, Tang B

Effect of gold nanoparticles on glutathione depletion-induced hydrogen peroxide generation andapoptosis in HL7702 cells.

Toxicol Lett. 2011 Aug 10;205(1):86-95. (IF 3.569)

24. Qu M, Li L, Chen C, Li M, Pei L, Chu F, Yang J, Yu Z, Wang D, Zhou Z.

Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons.

Neurosci Lett. 2011 Nov 21;505(3):286-90. (IF 2.274)

25. Chen HY, Zhang X, Chen SF, Zhang YX, Liu YH, Ma LL, Wang LX.

The protective effect of 17β-estradiol against hydrogen peroxide-induced apoptosis onmesenchymal stem cell.

Biomed Pharmacother. 2012 Feb;66(1):57-63. (IF 4.545)

26. Gong K, Xie J, Yi H, Li W.

CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

Biochem J. 2012 May 1;443(3):735-46. (IF 4.097)

27. Ren J, Cheng H, Xin WQ, Chen X, Hu K.

Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells.

Oncol Rep. 2012 Nov;28(5):1719-26. (IF 3.417)

28. Zhang H, Liu B, Wu J, Xu C, Tao J, Duan X, Cao Y, Dong J.

Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway.

Mol Med Rep. 2012 Nov;6(5):967-72. (IF 2.1)

29. Zhang H, Shao D, Wu Y, Cai C, Hu C, Shou X, Dai B, Ye B, Wang M, Jia X.

Apoptotic responses of Carassius auratus lymphocytes to nodularin exposure in vitro.

FISH SHELLFISH IMMUN. 2012 Dec;33(6):1229-37. (IF 3.298)

30. Shen XL, Zhang Y, Xu W, Liang R, Zheng J, Luo Y, Wang Y, Huang K.

An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of ochratoxin A in HEK293 cells.

J Proteomics. 2013 Jan 14;78:398-415. (IF 3.509)

31. Tan Q, Wu J, Li Y, Mei H, Zhao C, Zhang J.

A supermolecular curcumin for enhanced antiproliferative and proapoptotic activities: molecular characteristics,computer modeling and in vivo pharmacokinetics.

Nanotechnology. 2013 Jan 25;24(3):035102. (IF 3.551)

32. Li Z, Pan X, Wang T, Wang PN, Chen JY, Mi L.

Comparison of the killing effects between nitrogen-doped and pure TiO2 on HeLa cells with visible lightirradiation.

Nanoscale Res Lett. 2013 Feb 22;8(1):96. (IF 3.581)

33. Zhang H, Shao D, Wu Y, Dai B, Cai C, Fang W, Ye B, Zhang Y, liu J, Jia X.

Regulation of nodularin-induced apoptosis by epigallocatechin-3-gallate on fish lymphocytes in vitro.

FISH SHELLFISH IMMUN. 2013 May;34(5):1085-93. (IF 3.298)

34. Wang X, Bai H, Zhang X, Liu J, Cao P, Liao N, Zhang W, Wang Z, Hai C.

Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest andmitochondrial-dependent apoptosis.

Carcinogenesis. 2013 Jun;34(6):1323-30. (IF 4.603)

35. Peng Z, Liu M, Fang Z, Chen L, Wu J, Zhang Q.

In vitro antiproliferative effect of a water-soluble Laminaria japonica polysaccharide on human melanoma cell lineA375.

Food Chem Toxicol. 2013 Aug;58C:56-60. (IF 4.679)

36. Luo Y, Yang X, Zhao S, Wei C, Yin Y, Liu T, Jiang S, Xie J, Wan X, Mao M, Wu J.

Hydrogen Sulfide Prevents OGD/R-induced Apoptosis via Improving Mitochondrial Dysfunction and Suppressing an ROS-mediated Caspase-3 Pathway in Cortical Neurons.

Neurochem Int. 2013 Dec;63(8):826-31. (IF 3.881)

37. Zhang H, Xu HL, Fu WW, Xin Y, Li MW, Wang SJ, Yu XF, Sui DY.

20(S)-Protopanaxadiol Induces Human Breast Cancer MCF-7 Apoptosis through a Caspase-Mediated Pathway.

ASIAN PAC J CANCER P . 2014;15(18):7919-23. (IF 1.24)

38. Zhang S, Nie S, Huang D, Feng Y, Xie M.

A novel polysaccharide from Ganoderma atrum exerts antitumor activity by activating mitochondria-mediated apoptotic pathway and boosting the immune system.

J AGR FOOD CHEM. 2014 Feb 19;62(7):1581-9. (IF 4.192)

39. Lei T, Li H, Fang Z, Lin J, Wang S, Xiao L, Yang F, Liu X, Zhang J, Huang Z, Liao W.

Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress.

Neural Regen Res. 2014 Feb 1;9(3):260-7. (IF 3.171)

40. Cui YT, Liu B, Xie J, Xu P, Habte-Tsion HM, Zhang YY.

The effect of emodin on cytotoxicity, apoptosis and antioxidant capacity in the hepatic cells of grass carp (Ctenopharyngodon idellus).

FISH SHELLFISH IMMUN. 2014 May;38(1):74-9. (IF 3.298)

41. An Z, Qi Y, Huang D, Gu X, Tian Y, Li P, Li H, Zhang Y.

EGCG inhibits Cd(2+)-induced apoptosis through scavenging ROS rather than chelating Cd(2+) in HL-7702 cells.

TOXICOL MECH METHOD. 2014 May;24(4):259-67. (IF 2.295)

42. Shao D, Kan M, Qiao P, Pan Y, Wang Z, Xiao X, Li J, Chen L.

Celecoxib induces apoptosis via a mitochondria dependent pathway in the H22 mouse hepatoma cell line.

Mol Med Rep. 2014 Oct;10(4):2093-8. (IF 2.1)

43. Li Y, Zhang B, Huang K, He X, Luo Y, Liang R, Luo H, Shen XL, Xu W.

Mitochondrial proteomic analysis reveals the molecular mechanisms underlying reproductive toxicity of zearalenone in MLTC-1 cells.

Toxicology. 2014 Oct 3;324:55-67. (IF 4.099)

44. Kang Q, Yan S.

Piperlongumine reverses doxorubicin resistance through the PI3K/Akt signaling pathway in K562/A02 human leukemia cells.

Exp Ther Med. 2015 Apr;9(4):1345-1350. (IF 1.785)

45. Ying J, Xu H, Wu D, Wu X.

Emodin induces apoptosis of human osteosarcoma cells via mitochondria-and endoplasmic reticulum stress-related pathways.

INT J CLIN EXP PATHO. 2015 Oct 1;8(10):12837-44. (IF 0.252)

46. Liu B, Cui Y, Brown PB, Ge X, Xie J, Xu P.

Cytotoxic effects and apoptosis induction of enrofloxacin in hepatic cell line of grass carp (Ctenopharyngodon idellus).

FISH SHELLFISH IMMUN. 2015 Dec;47(2):639-44. (IF 3.298)

47. Zhang Q, Fan K, Wang P, Yu J, Liu R, Qi H, Sun H, Cao Y.

Carvacrol induces the apoptosis of pulmonary artery smooth muscle cells under hypoxia.

Eur J Pharmacol. 2016 Jan 5;770:134-46. (IF 3.263)

48. Zheng L, Wang C, Luo T, Lu B, Ma H, Zhou Z, Zhu D, Chi G, Ge P, Luo Y.

JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase ofIntracellular ROS Production.

Mol Neurobiol. 2016 May 16. [Epub ahead of print] (IF 4.5)

49. Qiao Z, He M, He MU, Li W, Wang X, Wang Y, Kuai Q, Li C, Ren S, Yu Q.

Synergistic antitumor activity of gemcitabine combined with triptolide in pancreatic cancer cells.

Oncol Lett. 2016 May;11(5):3527-3533. (IF 2.311)

50. Qiu J, Liu X, Li X, Zhang X, Han P, Zhou H, Shao L, Hou Y, Min Y, Kong Z, Wang Y, Wei Y, Liu X, Ni H, Peng J, Hou M.

CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immunethrombocytopenia.

SCI REP-UK. 2016 Jun 20;6:27445. (IF 3.998)

51. Zhou BR, Zhang LC, Permatasari F, Liu J, Xu Y, Luo D.

ALA-PDT elicits oxidative damage and apoptosis in UVB-induced premature senescence of human skinfibroblasts.

PHOTODIAGN PHOTODYN. 2016 Jun;14:47-56. (IF 2.894)

52. Chen G, Li SY, Malik HT, Ma YG, Xu H, Sun LK.

Organic two-photon nanoparticles modulate reactive oxygen species, intracellular calciumconcentration, and mitochondrial membrane potential during apoptosis of human gastric carcinoma SGC-7901 cells.

Biotechnol Lett. 2016 Aug;38(8):1269-76. (IF 1.977)

53. Li SY, Qi Y, Hu SH, Piao FY, Guan H, Wang ZM, Chen RL, Liu S.

Mesenchymal stem cells-conditioned medium protects PC12 cells against 2,5-hexanedione-induced apoptosis via inhibiting mitochondria-dependent caspase 3 pathway.

Toxicol Ind Health. 2017 Feb;33(2):107-118. (IF 1.708)

54. Zheng L, Wang C, Luo T, Lu B, Ma H, Zhou Z, Zhu D, Chi G, Ge P, Luo Y.

JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production.

Mol Neurobiol. 2017 Jul;54(5):3492-3505. (IF 4.5)

55. Lu XT, Ma Y, Zhang HJ, Jin MQ, Tang JH.

Enantioselective apoptosis and oxidative damage induced by individual isomers of profenofos in primary hippocampal neurons.

J ENVIRON HEALTH SCI. 2017 Jul 3;52(7):505-515. (IF 2.179)

56. Yan W, Li D, Chen T, Tian G, Zhou P, Ju X.

Umbilical Cord MSCs Reverse D-Galactose-Induced Hepatic Mitochondrial Dysfunction viaActivation of Nrf2/HO-1 Pathway.

Biol Pharm Bull. 2017 Aug 1;40(8):1174-1182. (IF 1.863)

57. Wu D, Zhao Y, Fu S, Zhang J, Wang W, Yan Z, Guo H, Liu A

Seleno-short-chain chitosan induces apoptosis in human breast cancer cells through mitochondrial apoptosis pathway in vitro.

Cell Cycle. 2018;17(13):1579-1590. (IF 3.699)

58. Jiang JH, Pi J, Jin H, Cai JY

Functional graphene oxide as cancer-targeted drug delivery system to selectively induce oesophageal cancer cell apoptosis.

ARTIF CELL NANOMED B. 2018;46(sup3):S297-S307. (IF 3.343)

59. Yin T, Zhang Y, Liu Y, Chen Q, Fu Y, Liang J, Zhou J, Tang X, Liu J, Huo M

The efficiency and mechanism of N-octyl-O, N-carboxymethyl chitosan-based micelles to enhance the oral absorption of silybin.

INT J PHARMACOL. 2018 Jan 30;536(1):231-240. (IF 0.692)

60. Ren J, Liu Y, Li L, Zhao Y, Li Z, Wu C, Chen L, Hu K

OAMDP, a novel podophyllotoxin derivative, induces apoptosis, cell cycle arrest and autophagy in hepatoma HepG2 cells.

Cell Biol Int. 2018 Feb;42(2):194-204. (IF 2.571)

61. Hu M, Zhao W, Li H, Gu J, Yan Q, Zhou X, Pan Z, Cui G, Jiao X

Immunization with recombinant Salmonella expressing SspH2-EscI protects mice against wild type Salmonella infection.

BMC Vet Res. 2018 Mar 9;14(1):79. (IF 1.835)

62. Yu X, Lin H, Wang Y, Lv W, Zhang S, Qian Y, Deng X, Feng N, Yu H, Qian B

d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer.

ONCOTARGETS THER. 2018 Apr 4;11:1833-1847. (IF 3.337)

63. Jiang JH, Pi J, Jin H, Yang F, Cai JY

Chinese herb medicine matrine induce apoptosis in human esophageal squamous cancer KYSE-150 cells through increasing reactive oxygen species and inhibiting mitochondrial function.

Pathol Res Pract. 2018 May;214(5):691-699. (IF 2.05)

64. Yan T, Hu G, Wang A, Sun X, Yu X, Jia J

Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells.

Phytother Res. 2018 May;32(5):898-907. (IF 4.087)

65. Wang Y, Xu H, Lu Z, Yu X, Lv C, Tian Y, Sui D

Pseudo-Ginsenoside Rh2 induces A549 cells apoptosis via the Ras/Raf/ERK/p53 pathway.

Exp Ther Med. 2018 Jun;15(6):4916-4924. (IF 1.785)

66. Gao W, Du X, Lei L, Wang H, Zhang M, Wang Z, Li X, Liu G, Li X

NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis.

J Cell Mol Med. 2018 Jul;22(7):3408-3422. (IF 4.486)

67. Liu X, Liu B, Zhou M, Fan F, Yu M, Gao C, Lu Y, Luo Y

Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis.

BIOCHEM BIOPH RES CO. 2018 Sep 18;503(4):2277-2285. (IF 2.985)

68. Liu CX, Tan YR, Xiang Y, Liu C, Liu XA, Qin XQ

Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury via Attenuation of ROS-Mediated Ca2+ Overload and Mitochondrial Dysfunction in Human Bronchial Epithelial Cells.

Biomed Res Int. 2018 Sep 30;2018:2070971. (IF 2.276)

69. Da-Wei Lian, Yi-Fei Xu, Wen-Kang Ren, Li-Jun Fu, Fang-Jun Chen, Li-Yao Tang, Hui-Ling Zhuang, Hong-Ying Cao, Ping Huang

Unraveling the Novel Protective Effect of Patchouli Alcohol Against Helicobacter pylori-Induced Gastritis: Insights Into the Molecular Mechanism in vitro and in vivo

Front Pharmacol. 2018 Nov 22;9:1347. doi: 10.3389/fphar.2018.01347. (IF 4.225)

70. Ren J, Yuan L, Wang Y, Chen G, Hu K

Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/MAPK and activating the Nrf2/ARE signalling pathways in HepG2 cells.

J Pharm Pharmacol. 2018 Dec;70(12):1643-1653. (IF 2.571)

71. Xi J, Zhang Z, Zhu Q, Zhong G

Evolution from Natural β-Carboline Alkaloids to Obtain 1,2,4,9-tetrahydro-3-thia-9-aza-fluorene Derivatives as Potent Fungicidal Agents against Rhizoctonia solani.

Int J Mol Sci. 2018 Dec 14;19(12). pii: E4044. (IF 4.556)

72. Nasser MI, Han T, Adlat S, Tian Y, Jiang N

Inhibitory effects of Schisandrin B on human prostate cancer cells.

Oncol Rep. 2019 Jan 41(1):677-685. (IF 3.417)

73. Wang W, Wang Y, Liu M, Zhang Y, Yang T, Li D, Huang Y, Li Q, Bai G, Shi L

Betulinic acid induces apoptosis and suppresses metastasis in hepatocellular carcinoma cell lines in vitro and in vivo.

J Cell Mol Med. 2019 Jan 23(1):586-595. (IF 4.486)

74. Wang J, Tang Z, Zhang Y, Qiu C, Zhu L, Zhao N, Liu Z

Matrine alleviates AGEs- induced cardiac dysfunctions by attenuating calcium overload via reducing ryanodine receptor 2 activity.

Eur J Pharmacol. 2019 Jan 5 842:118-124. (IF 3.263)

75. Ke XJ, Cheng YF, Yu N, Di Q.

Effects of carbamazepine on the P-gp and CYP3A expression correlated with PXR or NF-κB activity in the bEnd.3 cells.

Neurosci Lett. 2019 Jan 18 690:48-55. (IF 2.274)

76. Jiang JH, Pi J, Jin H, Cai JY

Oridonin-induced mitochondria-dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways.

J Cell Biochem. 2019 Mar 120(3):3736-3746. (IF 4.237)

77. Tian Z, Jia H, Jin Y, Wang M, Kou J, Wang C, Rong X, Xie X, Han G, Pang X

Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro.

Food Nutr Res. 2019 Apr 15 63. (IF 3.647)

78. Zhang F, Ni H, Li X, Liu H, Xi T, Zheng L

LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.

FEBS Lett. 2019 Aug 593(15):1993-2007. (IF 3.057)

79. Zhang C, Han F, Shi M, Sun H, Li Y, Ci Y, Yao Y, Dou P, Akhtar ML, Nie H, He J, Li Y

MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system.

MOL CARCINOGEN. 2019 Aug 58(8):1410-1426. (IF 3.825)

80. Zhao ZM, Shang XF, Lawoe RK, Liu YQ, Zhou R, Sun Y, Yan YF, Li JC, Yang GZ, Yang CJ

Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine.

PESTIC BIOCHEM PHYS. 2019 Sep 159:51-58. (IF 2.751)

81. Ren J, Yuan L, Wang W, Zhang M, Wang Q, Li S, Zhang L, Hu K

Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway.

TOXICOL APPL PHARM . 2019 Sep 1 378:114617. (IF 3.616)

82. Hu Q, Zhao F, Fan M, He C, Yang X, Huang Z, Fu Z.

The influence of titanium dioxide nanoparticles on their cellular response to macrophage cells.

COMP BIOCHEM PHYS C. 2019 Sep 223:42-52. (IF 2.892)

83. Liu B, Yang Z, Bo L, Zhao Z, Zhou Q, Sun C

Cytotoxic effects, inflammatory response and apoptosis induction of cyclophosphamide in the peripheral blood leukocyte of blunt snout bream (Megalobrama amblycephala).

FISH SHELLFISH IMMUN. 2019 Oct 93:174-182. (IF 3.298)

84. Zhang L, Wu T, Olatunji OJ, Tang J, Wei Y, Ouyang Z

N6-(2-hydroxyethyl)-adenosine from Cordyceps cicadae attenuates hydrogen peroxide induced oxidative toxicity in PC12 cells.

Metab Brain Dis. 2019 Oct 34(5):1325-1334. (IF 2.726)

85. Li JC, Wang RX, Sun Y, Zhu JK, Hu GF, Wang YL, Zhou R, Zhao ZM, Liu YQ, Peng JW, Yan YF, Shang XF

Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives.

Bioorg Chem. 2019 Nov 92:103266. (IF 4.831)

86. Tang H, Wu YJ, Xiao F, Wang B, Asenso J, Wang Y, Sun W, Wang C, Wei W

Regulation of CP-25 on P-glycoprotein in synoviocytes of rats with adjuvant arthritis.

Biomed Pharmacother. 2019 Nov 119:109432. (IF 4.545)

87. Shen J, Wang J, Du J, Wang L, Zhou X, Chang X, Li Z, Zhai X, Zuo D, Wu Y

A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.

TOXICOL APPL PHARM . 2019 Nov 15 383:114781. (IF 3.616)

88. Lu H, Shu Q, Lou H, Chen Q

Mitochondria-Mediated Programmed Cell Death in Saccharomyces cerevisiae Induced by Betulinic Acid Is Accelerated by the Deletion of PEP4 Gene.

Microorganisms. 2019 Nov 7 7(11). pii: E538. (IF 4.152)

89. Xu X, Feng Y, Chen X, Wang Q, Meng T, Liu A

Antitumor effects of seleno-β-lactoglobulin on human breast cancer MCF-7 and MDA-MB-231 cells in vitro.

Toxicol In Vitro. 2019 Dec 61:104607. (IF 2.959)

90. Xiaodong Xie, Xiaofei Song, Xin Liu, Xiaogang Luo, Maidina Nabijiang, Mengqi Ma, Ying Li

Up-Regulation of GATA4 Regulates Human Lens Epithelial Cell Function in Age-Related Cataract

Ophthalmic Res. 2020;63(6):564-571. doi: 10.1159/000507962. (IF 1.961)

91. Ming Liu, Xue-Qing Song, Yuan-Di Wu, Jing Qian, Jing-Yuan Xu

Cu(ii)-TACN complexes selectively induce antitumor activity in HepG-2 cells via DNA damage and mitochondrial-ROS-mediated apoptosis

DALTON T. 2020 Jan 7;49(1):114-123. doi: 10.1039/c9dt03641e. (IF 4.174)

92. Yan Li, Jing Shi, Xinting Sun, Yafeng Li, Yinyin Duan, Huankai Yao

Theaflavic acid from black tea protects PC12 cells against ROS-mediated mitochondrial apoptosis induced by OGD/R via activating Nrf2/ARE signaling pathway

J NAT MED-TOKYO. 2020 Jan;74(1):238-246. doi: 10.1007/s11418-019-01333-4. (IF 2.055)

93. Hongfei Wang, Fangxiao Dong, Ye Wang, Xu'an Wang, Defei Hong, Yingbin Liu, Jian Zhou

Betulinic acid induces apoptosis of gallbladder cancer cells via repressing SCD1

ACTA BIOCH BIOPH SIN. 2020 Feb 3;52(2):200-206. doi: 10.1093/abbs/gmz148. (IF 2.836)

94. Jie Zhang, Yiyi Li, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, Zhaohui Zhang

Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway

Front Mol Neurosci. 2020 Feb 6;13:16. doi: 10.3389/fnmol.2020.00016. (IF 4.057)

95. Xin Wei, Cheng Sun, Ren-Peng Zhou, Gang-Gang Ma, Yang Yang, Chao Lu, Wei Hu

Nerve growth factor promotes ASIC1a expression via the NF-κB pathway and enhances acid-induced chondrocyte apoptosis

Int Immunopharmacol. 2020 Mar 5;82:106340. doi: 10.1016/j.intimp.2020.106340. (IF 3.943)

96. Zhanjun Ma, Jingjing Yang, Yang Yang, Xuexi Wang, Guohu Chen, Ancheng Shi, Yubao Lu, Shouning Jia, Xuewen Kang, Li Lu

Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway

Phytomedicine. 2020 Mar;68:153186. doi: 10.1016/j.phymed.2020.153186. (IF 4.268)

97. Yi L, Juan W, Gang C, Leiming Z, Jianning Z

Seawater Immersion Aggravates Early Mitochondrial Dysfunction and Increases Neuronal Apoptosis After Traumatic Brain Injury.

Cell Mol Neurobiol. 2020 Apr 40(3):447-457. (IF 3.606)

98. Dan Su, Wenbin Wang, Xinyue Wu, Minyue Li, Xuelong Yan, Zhonghong Hua, Jiahui Liu, Zhiyu Zhu, Kun Hu, Jie Ren

Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH-SY5Y cells

J Pharm Pharmacol. 2020 Apr;72(4):561-574. doi: 10.1111/jphp.13224. (IF 2.571)

99. Haiyan Yin, Hui Zhang, Youhua Kong, Chunmei Wang, Yan Guo, Yang Gao, Lili Yuan, Xinxin Yang, Jing Chen

Apelin protects auditory cells from cisplatin-induced toxicity in vitro by inhibiting ROS and apoptosis

Neurosci Lett. 2020 May 29;728:134948. doi: 10.1016/j.neulet.2020.134948. (IF 2.274)

100. Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia

Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Int J Mol Med. 2020 May;45(5):1514-1524. doi: 10.3892/ijmm.2020.4513. (IF 3.098)

101. Le Hu, Yan Fu, Liyuan Rong, Xinji Yang, Yueyue Li, Liqiang Wang, Wei Wu

Evaluating the cytotoxicity of graphene oxide using embryonic stem cells-derived cells

J Biomed Mater Res A. 2020 Jun;108(6):1321-1328. doi: 10.1002/jbm.a.36904. (IF 3.525)

102. Xing-Hua Wang, Shen Yin, Xiang-Hong Ou, Shi-Ming Luo

Increase of mitochondria surrounding spindle causes mouse oocytes arrested at metaphase I stage

BIOCHEM BIOPH RES CO. 2020 Jul 5;527(4):1043-1049. doi: 10.1016/j.bbrc.2020.05.037. (IF 2.985)

103. Jin-Huan Jiang, Jiang Pi, Ji-Ye Cai

Oridonin exhibits anti-angiogenic activity in human umbilical vein endothelial cells by inhibiting VEGF-induced VEGFR-2 signaling pathway

Pathol Res Pract. 2020 Aug;216(8):153031. doi: 10.1016/j.prp.2020.153031. (IF 2.05)

104. Jie Zhang, Changling Ding, Shuping Zhang, Yangyang Xu

Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3β/Nrf2 signalling pathway in vitro

J Cell Mol Med. 2020 Aug;24(16):8977-8985. doi: 10.1111/jcmm.15531. (IF 4.486)

105. Lijing Wang, Xiaobo Xu, Tong Liu, Junfang Wang, Jiwei Shen, Ming Guo, Yingliang Wu, Xin Zhai, Daiying Zuo

1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protecti

J Pharm Pharmacol. 2020 Oct;72(10):1370-1382. doi: 10.1111/jphp.13315. (IF 2.571)

106. Jiawen Wang, Shuai Bian, Siming Wang, Song Yang, Wanying Zhang, Daqing Zhao, Meichen Liu, Xueyuan Bai

Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation

Chinese Medical Journal. 2020 Nov 12;15(1):118. doi: 10.1186/s13020-020-00396-w.

107. Yin-Fang Yan, Cheng-Jie Yang, Xiao-Fei Shang, Zhong-Min Zhao, Ying-Qian Liu, Rui Zhou, Hua Liu, Tian-Lin Wu, Wen-Bin Zhao, Yu-Ling Wang, Guan-Fang Hu, Fang Qin, Ying-Hui He, Hai-Xin Li, Sha-Sha Du

Bioassay-guided isolation of two antifungal compounds from Magnolia officinalis, and the mechanism of action of honokiol

PESTIC BIOCHEM PHYS. 2020 Nov;170:104705. doi: 10.1016/j.pestbp.2020.104705. (IF 2.751)

108. Ying Liu, Jiawen Wang, Juhui Qiao, Shichao Liu, Siming Wang, Daqing Zhao, Xueyuan Bai, Meichen Liu

Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1

Int J Mol Med. 2020 Nov;46(5):1695-1706. doi: 10.3892/ijmm.2020.4725. (IF 3.098)

109. Jie Yang, Wen-Wen Mu, Guo-Yun Liu

Synthesis and evaluation of the anticancer activity of bischalcone analogs in human lung carcinoma (A549) cell line

Eur J Pharmacol. 2020 Dec 5;888:173396. doi: 10.1016/j.ejphar.2020.173396. (IF 3.263)

110. Lin Yang, Delin Kong, Mei He, Jiawei Gong, Yuzhe Nie, Sheng Tai, Chun-Bo Teng

MiR-7 mediates mitochondrial impairment to trigger apoptosis and necroptosis in Rhabdomyosarcoma

BBA-MOL CELL RES. 2020 Dec;1867(12):118826. doi: 10.1016/j.bbamcr.2020.118826. (IF 4.105)

111. Wei Zhao, Jia-Xin Liu, Fang Guo, Xin-Guang Liu

Yeast MED2 is involved in the endoplasmic reticulum stress response and modulation of the replicative lifespan

Mech Ageing Dev. 2020 Dec;192:111381. doi: 10.1016/j.mad.2020.111381. (IF 4.304)

112. Yahan Sun, Kunyan Zhou, Mali He, Ying Gao, Danjie Zhang, Yanwen Bai, Yuezhao Lai, Mengying Liu, Xuechao Han, Sen Xu, Wei Tian, Jingman Xu

The Effects of Different Fluorescent Indicators in Observing the Changes of the Mitochondrial Membrane Potential during Oxidative Stress-Induced Mitochondrial Injury of Cardiac H9c2 Cells

J Fluoresc. 2020 Dec;30(6):1421-1430. doi: 10.1007/s10895-020-02623-x. (IF 2.093)

113. Jiahua Zheng, Shaochai Wei, Tingting Xiao, Guanwu Li

LC3B/p62-mediated mitophagy protects A549 cells from resveratrol-induced apoptosis

Life Sci. 2021 Apr 15;271:119139. doi: 10.1016/j.lfs.2021.119139. (IF 3.647)

114. Tingting Zhang, Hui Liu, Min Liu, Chunhong Wang

Farrerol suppresses the progression of laryngeal squamous cell carcinoma via the mitochondria-mediated pathway

Eur J Pharmacol. 2021 Dec 15;913:174636. doi: 10.1016/j.ejphar.2021.174636. (IF 3.263)

115. Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye

Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Clin Sci (Lond). 2022 Nov 30;136(22):1711-1730. doi: 10.1042/CS20220242.