化学信息：
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化学名
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1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea
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简称
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LED209
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别名
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LED 209, LED-209
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中文名
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N/A
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化学式
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C19H17N3O2S2
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分子量
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383.49
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CAS号
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245342-14-7
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纯度
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98%
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溶剂/溶解度
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Water<1mg/ml; DMSO20mg/ml; Ethanol20mg/ml
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溶液配制
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5mg加入1.3ml DMSO，或者每3.83mg加入1ml DMSO，配制成10mM溶液。SC3310-10mM用DMSO配制。
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生物信息：
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产品描述
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LED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC.
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信号通路
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Anti-infection
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靶点
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Antibacterial
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－
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－
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－
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－
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IC50
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－
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－
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－
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－
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－
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体外研究
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LED209 has desirable pharmacokinetics and does not present toxicity in vitro and in rodents. This is a unique antivirulence approach, with a proven broad-spectrum activity against multiple Gram-negative pathogens that cause mammalian infections.The LED209 QseC inhibitor has a unique mode of action by acting as a prodrug scaffold to deliver a warhead that allosterically modifies QseC, impeding virulence in several Gram-negative pathogens. LED209 is QseC sensor kinase inhibitor , as a potential lead compound to combat infections with Legionella or Mycobacterium spp. LED209 inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 inhibits EHEC virulence traits in vitro. LED209 markedly inhibits the virulence of several pathogens in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs.
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体内研究
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N/A
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临床实验
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N/A
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特征
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N/A
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相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
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酶活性检测实验
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方法
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N/A
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细胞实验
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细胞系
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N/A
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浓度
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N/A
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处理时间
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N/A
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方法
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N/A
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动物实验
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动物模型
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N/A
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配制
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N/A
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剂量
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N/A
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给药方式
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N/A
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参考文献：
1. CurtismM, et al. MBio. 2014 Nov 11, 5(6), e02165.
2. Harrison CF, et al. Microbiology. 2015 Jul, 161(7), 1392-406.
3. Rasko DA, et al. Science. 2008 Aug 22, 321(5892), 1078-80.
包装清单：
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产品编号
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产品名称
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包装
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SC3310-10mM
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LED209 (QseC抑制剂)
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10mM×0.2ml
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SC3310-5mg
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LED209 (QseC抑制剂)
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5mg
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SC3310-25mg
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LED209 (QseC抑制剂)
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25mg
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—
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说明书
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1份
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保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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