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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1026-10mM | 咖啡酸苯乙酯(98%, HPLC) | 10mM×0.2ml | 87.00元 |
| SM1026-5mg | 咖啡酸苯乙酯(98%, HPLC) | 5mg | 72.00元 |
| SM1026-25mg | 咖啡酸苯乙酯(98%, HPLC) | 25mg | 300.00元 |
| SM1026-100mg | 咖啡酸苯乙酯(98%, HPLC) | 100mg | 1020.00元 |
化学信息：
| 中文名 | 咖啡酸苯乙酯 |
| 英文名 | Caffeic acid phenethyl ester |
| 中文别名 | - |
| 英文别名 | CAPE; Phenylethyl caffeate |
| 来源 | 意大利蜂Apis mellifera L. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>苯丙酸类 |
| 化学式 | C17H16O4 |
| 分子量 | 284.31 |
| CAS号 | 104594-70-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 28.4 mg/mL (100 mM) |
| 溶液配制 | 5mg加入1.76ml DMSO，或者每2.84mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1). | ||||
| 信号通路 | Apoptosis; NF-κB; PI3K/Akt | ||||
| 靶点 | p38 MAPK | p70S6K | HIF-1α | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Caffeic acid phenethyl ester blocks NF-κB activation induced by phorbol ester, ceramide, okadaic acid, and hydrogen peroxide by preventing the translocation of the p65 subunit of NF-κB to the nucleus. In a series of tumor cell lines, Caffeic acid phenethyl ester shows promising antiproliferative activity with EC50 of 1.76, 3.16, 13.7, and 44.0 μM against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines, respectively. Caffeic acid phenethyl ester, as a potent antioxidant, exerts its anti-apoptotic effect in cerebellar granule cells by blocking ROS formation and inhibiting caspase activity. Moreover, Caffeic acid phenethyl ester attenuates the pro-inflammatory phenotype of LPS-stimulated HSCs, and LPS-induced sensitization of HSCs to fibrogenic cytokines by inhibiting NF-κB signaling. | ||||
| 体内研究 | In vivo, Caffeic acid phenethyl ester (10 mg/kg, i.p.) inhibits the growth and angiogenesis of primary tumors in C57BL/6 and BALB/c mice inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells. Caffeic acid phenethyl ester (5, 10, 20 mg/kg) also shows immunomodulatory effects in vivo by decreasing thymus weight and/or cellularity of thymus and spleen. | ||||
| 临床实验 | N/A | ||||
1. Lin HP, et al. Oncotarget. 2015,6(9):6684-707.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1026-10mM | 咖啡酸苯乙酯(98%, HPLC) | 10mM×0.2ml |
| SM1026-5mg | 咖啡酸苯乙酯(98%, HPLC) | 5mg |
| SM1026-25mg | 咖啡酸苯乙酯(98%, HPLC) | 25mg |
| SM1026-100mg | 咖啡酸苯乙酯(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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