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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1039-10mM | 毛蕊花糖苷(98%, HPLC) | 10mM×0.2ml | 133.00元 |
| SM1039-5mg | 毛蕊花糖苷(98%, HPLC) | 5mg | 104.00元 |
| SM1039-25mg | 毛蕊花糖苷(98%, HPLC) | 25mg | 432.00元 |
| SM1039-100mg | 毛蕊花糖苷(98%, HPLC) | 100mg | 1469.00元 |
化学信息：
| 中文名 | 毛蕊花糖苷 |
| 英文名 | Verbascoside |
| 中文别名 | 毛蕊花甙；麦角甾苷；类叶升麻苷 |
| 英文别名 | Acteoside; Kusaginin; TJC160 |
| 来源 | 大叶紫珠Callicarpa macrophylla Vahl；肉苁蓉Cistanche deserticola Ma；马缨丹Lantana camara L. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>苯丙酸类 |
| 化学式 | C29H36O15 |
| 分子量 | 624.59 |
| CAS号 | 61276-17-3 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO : ≥ 100 mg/ml (160.11 mM) |
| 溶液配制 | 10mg加入1.60ml DMSO，或者每6.25mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. | ||||
| 信号通路 | - | ||||
| 靶点 | PKC | ATP | Histone | - | - |
| IC50 | 25 µM | 22 µM | 28 µM | - | - |
| 体外研究 | Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM. Verbascoside shows Kis of 22 and 28 µM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC50 of 13 µM. Verbascoside (5, 10 µM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells. | ||||
| 体内研究 | Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3. | ||||
| 临床实验 | N/A | ||||
1. Herbert JM, et al. J Nat Prod. 1991,54(6):1595-600.
2.Li Y, et al. Int Arch Allergy Immunol. 2018,175(4):220-230.
3.Amin B, et al. Phytother Res. 2016,30(1):128-35.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1039-10mM | 毛蕊花糖苷(98%, HPLC) | 10mM×0.2ml |
| SM1039-5mg | 毛蕊花糖苷(98%, HPLC) | 5mg |
| SM1039-25mg | 毛蕊花糖苷(98%, HPLC) | 25mg |
| SM1039-100mg | 毛蕊花糖苷(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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