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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1085-10mM | 五味子醇甲(98%, HPLC) | 10mM×0.2ml | 92.00元 |
| SM1085-5mg | 五味子醇甲(98%, HPLC) | 5mg | 58.00元 |
| SM1085-25mg | 五味子醇甲(98%, HPLC) | 25mg | 240.00元 |
| SM1085-100mg | 五味子醇甲(98%, HPLC) | 100mg | 816.00元 |
化学信息：
| 中文名 | 五味子醇甲 |
| 英文名 | Schisandrin |
| 中文别名 | 五味子素 |
| 英文别名 | Wuweizichun A; Wuweizi alcohol A; Schisandrin; Schisandrol A |
| 来源 | 五味子Schisandra chinensis (Turcz.) Baill. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>木脂素>联苯环辛烯类 |
| 化学式 | C24H32O7 |
| 分子量 | 432.51 |
| CAS号 | 7432-28-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 4.33 mg/ml (10 mM) |
| 溶液配制 | 5mg加入1.16ml DMSO，或者每4.33mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats. | ||||
| 信号通路 | Inflammation; Apoptosis | ||||
| 靶点 | NO | Prostaglandin E2 | COX-2 | - | - |
| IC50 | 10-100 μM | 25-100 μM | 25-100 μM | - | - |
| 体外研究 | Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells. Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages. Schisandrin inhibits the SK-HEP-1, SNU-638, and T47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively. Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance. | ||||
| 体内研究 | Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice. Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats. | ||||
| 临床实验 | N/A | ||||
1.Guo LY, et al. Eur J Pharmacol. 2008,591(1-3):293-9.
2.Egashira N, et al. Phytother Res. 2008,22(1):49-52.
3.Min HY, et al. Bioorg Med Chem Lett. 2008,18(2):523-6.
4.Zhang ZL, et al. Breast Cancer. 2018,25(2):233-242.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1085-10mM | 五味子醇甲(98%, HPLC) | 10mM×0.2ml |
| SM1085-5mg | 五味子醇甲(98%, HPLC) | 5mg |
| SM1085-25mg | 五味子醇甲(98%, HPLC) | 25mg |
| SM1085-100mg | 五味子醇甲(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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