微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2001-10mM | 芒果苷(98%, HPLC) | 10mM×0.2ml | 98.00元 |
| SM2001-5mg | 芒果苷(98%, HPLC) | 5mg | 72.00元 |
| SM2001-25mg | 芒果苷(98%, HPLC) | 25mg | 300.00元 |
| SM2001-100mg | 芒果苷(98%, HPLC) | 100mg | 1020.00元 |
化学信息：
| 中文名 | 芒果苷 |
| 英文名 | Mangiferin |
| 中文别名 | 杧果甙；芒果甙 |
| 英文别名 | Euxanthogen; Chinomine; Alpizarin; Hedysaride; Mannipherin; Chedisaride; Shamimin |
| 来源 | 红花龙胆Gentiana rhodantha Franch.；知母Anemarrhena asphodeloides Bunge |
| 化合物类型 | 黄酮类(Flavonoids)>（口山）酮 |
| 化学式 | C19H18O11 |
| 分子量 | 422.34 |
| CAS号 | 4773-96-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 22 mg/ml (52.09 mM; Need ultrasonic and warming) |
| 溶液配制 | 5mg加入1.18ml DMSO，或者每4.22mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. | ||||
| 信号通路 | - | ||||
| 靶点 | p65 | p50 | Nrf2 | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Mangiferin is glucosylxanthone extracted from plants of the Anacardiaceae and Gentianaceae families. Mangiferin (50 μM) significantly increases Nrf2 protein accumulation in HL-60 cells, particularly in the nucleus. Mangiferin also enhances the binding of Nrf2 to an antioxidant response element (ARE), significantly up-regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) expression and reduces intracellular ROS in HL60 cells. Mangiferin alone dose-dependently inhibits the proliferation of HL-60 cells. In mononuclear cells (MNCs), Mangiferin significantly relieves oxidative stress, but attenuates etoposide-induced cytotoxicity. Mangiferin is a natural phytopolyphenol that exhibits various pharmacological properties. Mangiferin is present in several plant species such as Mangifera indica, Iris unguicularis, and Anemarrhena asphodeloides. Mangiferin downregulates TNF-α-induced MMP-9 mRNA and protein expression by suppressing NF-κB activity, consequently suppressing the invasion of LNCaP cells.To assess whether Mangiferin influences the viability of LNCaP cells, MTT assay is performed 24 h after treatment with different concentrations of Mangiferin in the presence or absence of TNF-α in serum and serum-free conditions. There are no cytotoxic evident in LNCaP cells treated with up to 400 μM of Mangiferin alone under both serum and serum-free conditions. Additionally, in the presence of TNF-α (20 ng/ml), Mangiferin does not affect cell viability. Mangiferin (400 μM) treatment significantly decreases the NF-κB luciferase activity in TNF-α-stimulated LNCaP cells. Pretreatment with Mangiferin (400 μM) for 1 h significantly decreases TNF-α-induced NF-κB activity. The RT-PCR shows that Mangiferin (400 μM) significantly suppresses the TNF-α-induced MMP-9 expression in LNCaP cells. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1. Zhang BP, et al. Acta Pharmacol Sin. 2014,35(2):257-66.
2. Dilshara MG, et al. BMB Rep. 2015,48(10):559-64.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2001-10mM | 芒果苷(98%, HPLC) | 10mM×0.2ml |
| SM2001-5mg | 芒果苷(98%, HPLC) | 5mg |
| SM2001-25mg | 芒果苷(98%, HPLC) | 25mg |
| SM2001-100mg | 芒果苷(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
