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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2077-10mM | 芫花素(98%, HPLC) | 10mM×0.2ml | 126.00元 |
| SM2077-5mg | 芫花素(98%, HPLC) | 5mg | 204.00元 |
| SM2077-25mg | 芫花素(98%, HPLC) | 25mg | 850.00元 |
| SM2077-100mg | 芫花素(98%, HPLC) | 100mg | 2890.00元 |
化学信息：
| 中文名 | 芫花素 |
| 英文名 | Genkwanin |
| 中文别名 | - |
| 英文别名 | Apigenin 7-methyl ether; Puddumetin |
| 来源 | 芫花Daphne genkwa Sieb. et Zucc. |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮 |
| 化学式 | C16H12O5 |
| 分子量 | 284.26 |
| CAS号 | 437-64-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 5 mg/ml (17.59 mM); Water: < 0.1 mg/ml (insoluble) |
| 溶液配制 | 5mg加入1.76ml DMSO，或者每2.84mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities. | ||||
| 信号通路 | AP-1 | ||||
| 靶点 | NO | p38 | JNK | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Cell viability analysis shows that Genkwanin does not affect the cell viability up to a concentration of 50 μM. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation. Originally identified as an immediate early gene, MKP-1 is then found to be a dual specificity phosphatase acting as a negative regulator of ERK1/2, JNK and p38 MAPK activities, with predominant effects on the latter two. Pretreatment with Genkwanin markedly up-regulates the expression of MKP-1 without affecting MKP-1 mRNA. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1. Gao Y et al. PLoS One. 2014,9(5):e96741.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2077-10mM | 芫花素(98%, HPLC) | 10mM×0.2ml |
| SM2077-5mg | 芫花素(98%, HPLC) | 5mg |
| SM2077-25mg | 芫花素(98%, HPLC) | 25mg |
| SM2077-100mg | 芫花素(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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