微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5024-10mM | 木香烃内酯(98%, HPLC) | 10mM×0.2ml | 82.00元 |
| SM5024-5mg | 木香烃内酯(98%, HPLC) | 5mg | 65.00元 |
| SM5024-25mg | 木香烃内酯(98%, HPLC) | 25mg | 270.00元 |
| SM5024-100mg | 木香烃内酯(98%, HPLC) | 100mg | 918.00元 |
化学信息：
| 中文名 | 木香烃内酯 |
| 英文名 | Costunolide |
| 中文别名 | 木香内酯 |
| 英文别名 | Costus lactone；NSC 106404；Costunolid |
| 来源 | 木香Aucklandia lappa Decne. |
| 化合物类型 | 萜类(Terpenoids)>倍半萜>倍半萜内酯 |
| 化学式 | C15H20O2 |
| 分子量 | 232.32 |
| CAS号 | 553-21-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 49 mg/mL (210.92 mM) |
| 溶液配制 | 3mg加入1.29ml DMSO，或者每2.32mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells. | ||||
| 信号通路 | c-Myc/p53; AKT/14-3-3 | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Costunolide inhibits the colony formation, migrative and invasive abilities of the H1299 cells in a dose or time dependent manner. Costunolide (6.7-215.2 μM; 24 hours) inhibits the viability of H1299 cells in a dose-dependent manner, with an IC50 of 23.93 µM. Costunolide (12.0-48.0 µM; 48 hours) induces apoptosis in H1299 cells. Costunolide (12-48.0 µM; 6-12 hours) regulates metastasis- and proliferation-associated mRNA expression. Costunolide regulates epithelial-to-mesenchymal transition (EMT)-associated protein expression. Costunolide regulates c-Myc mediated apoptosis signaling and 14-3-3-mediated signaling pathways in breast cancer cells. | ||||
| 体内研究 | Costunolide (20 mg/kg; i.p; daily; for 30 days) inhibits breast cancer through c-Myc/p53 and AKT/14-3-3 pathway. | ||||
| 临床实验 | N/A | ||||
1. Dae Yong Kim, et al. Int J Mol Sci. 2019,20(12):2926.
2. Minyan Wei, et al. Oncol Rep. 2020,43(6):1986-1994.
3. Zhangxiao Peng, et al. Sci Rep. 2017,7:41254.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5024-10mM | 木香烃内酯(98%, HPLC) | 10mM×0.2ml |
| SM5024-5mg | 木香烃内酯(98%, HPLC) | 5mg |
| SM5024-25mg | 木香烃内酯(98%, HPLC) | 25mg |
| SM5024-100mg | 木香烃内酯(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
