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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5076-5mg | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 5mg | 108.00元 |
| SM5076-10mM | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 10mM×0.2ml | 116.00元 |
| SM5076-25mg | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 25mg | 450.00元 |
| SM5076-100mg | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 100mg | 1530.00元 |
化学信息：
| 中文名 | 8-O-乙酰山栀苷甲酯 |
| 英文名 | Barlerin |
| 中文别名 | - |
| 英文别名 | 8-O-Acetyl shanzhiside methyl ester |
| 来源 | 独一味Lamiophlomis rotata (Benth) Kudo |
| 化合物类型 | 萜类(Terpenoids)>单萜>环烯醚萜苷 |
| 化学式 | C19H28O12 |
| 分子量 | 448.42 |
| CAS号 | 57420-46-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (223.01 mM) |
| 溶液配制 | 5mg加入1.12ml DMSO，或者每4.48mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt NF-κB. | ||||
| 信号通路 | - | ||||
| 靶点 | NF-κB | HMGB-1 | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Treatment of SH-SY5Y cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 (HMGB-1) expression. Treatment of H9c2 cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB-1) expression. | ||||
| 体内研究 | Barlerin (8-O-Acetyl shanzhiside methyl ester) 40 mg/kg demonstrates significant neuroprotective effect even after delayed administration at 4 hr after I/R. Barlerin 40 mg/kg attenuates the histopathological damage, decreases brain swelling, inhibits NF-κB activation and reduces HMGB-1 expression in ischaemic brain tissue. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. Barlerin also significantly increases vascularization compared with vehicle treatment. It increases the expression of VEGF, Ang1, phosphorylation of Tie2 and Akt VEGF. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time, prothrombin time or thrombin time. It significantly prolongs euglobulin clot lysis time in hyperfibrinolysis mice. | ||||
| 临床实验 | N/A | ||||
1. Zhang L, et al. Basic Clin Pharmacol Toxicol. 2014,115(6):481-7.
2. Kang ZC, et al. Eur J Pharm Sci. 2012,47(1):124-30.
3. Jiang WL, et al. Basic Clin Pharmacol Toxicol. 2011,108(1):21-7.
4. Fan PC, et al. J Ethnopharmacol. 2016,187:232-8.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5076-10mM | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 10mM×0.2ml |
| SM5076-5mg | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 5mg |
| SM5076-25mg | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 25mg |
| SM5076-100mg | 8-O-乙酰山栀苷甲酯(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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