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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5152-10mM | 冬凌草甲素(98%, HPLC) | 10mM×0.2ml | 89.00元 |
| SM5152-5mg | 冬凌草甲素(98%, HPLC) | 5mg | 60.00元 |
| SM5152-25mg | 冬凌草甲素(98%, HPLC) | 25mg | 252.00元 |
| SM5152-100mg | 冬凌草甲素(98%, HPLC) | 100mg | 857.00元 |
化学信息：
| 中文名 | 冬凌草甲素 |
| 英文名 | Oridonin |
| 中文别名 | - |
| 英文别名 | Isodonol; Rubescensin; Rubescensin A |
| 来源 | 冬凌草Rabdosia rubescens (Hemsl.) Hara |
| 化合物类型 | 萜类(Terpenoids)>二萜 |
| 化学式 | C20H28O6 |
| 分子量 | 364.43 |
| CAS号 | 28957-04-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 150 mg/mL (411.60 mM) |
| 溶液配制 | 5mg加入1.37ml DMSO，或者每3.64mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects. | ||||
| 信号通路 | Apoptosis; AKT/mTOR | ||||
| 靶点 | Akt1 | AKT2 | - | - | - |
| IC50 | 8.4 μM | 8.9 μM | - | - | - |
| 体外研究 | Oridonin is an ATP-competitive inhibitor of AKT with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. Oridonin (5, 10 or 20 μM) obviously inhibits the growth of KYSE70, KYSE410 and KYSE450 ESCC cells via targeting AKT1/2. Oridonin (10 or 20 μM) causes G2/M phase cell cycle arrest in KYSE70, KYSE410 and KYSE450 cells, and induces apoptosis in these three cell lines at 20 μM. In addition, Oridonin (5, 10 or 20 μM) in combination with cisplatin or 5-FU enhances the inhibition of esophageal squamous cell carcinoma (ESCC) cell growth. Oridonin (0.1 and 1 μM) preferentially suppresses AKT/mTOR signaling. Oridonin (1 μM) also selectively suppresses growth of breast cancer cells with hyperactivation of AKT signaling. | ||||
| 体内研究 | Oridonin (160 mg/kg, p.o.) shows significant reduction in the tumor growth without obvious weigh loss in SCID mice bearing EG9 and HEG18 tumor cells. Oridonin treatment also suppresses the expression of Ki-67, phosphorylated AKT, GSK-3β or mTOR in mice. Oridonin (15 mg/kg, i.p.) impairs cell growth in breast cancer with hyperactivation of AKT signaling in nude mice. | ||||
| 临床实验 | N/A | ||||
1. Song M, et al. Mol Cancer Ther. 2018,17(7):1540-1553.
2. Sun B, et al. Oncotarget. 2018,9(35):23878-23889.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5152-10mM | 冬凌草甲素(98%, HPLC) | 10mM×0.2ml |
| SM5152-5mg | 冬凌草甲素(98%, HPLC) | 5mg |
| SM5152-25mg | 冬凌草甲素(98%, HPLC) | 25mg |
| SM5152-100mg | 冬凌草甲素(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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