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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6076-10mM | 柴胡皂苷D (98%, HPLC) | 10mM×0.2ml | 173.00元 |
| SM6076-5mg | 柴胡皂苷D (98%, HPLC) | 5mg | 132.00元 |
| SM6076-25mg | 柴胡皂苷D (98%, HPLC) | 25mg | 550.00元 |
| SM6076-100mg | 柴胡皂苷D (98%, HPLC) | 100mg | 1870.00元 |
化学信息：
| 中文名 | 柴胡皂苷D |
| 英文名 | Saikosaponin D |
| 中文别名 | 柴胡皂甙D |
| 英文别名 | - |
| 来源 | 狭叶柴胡Bupleurum scorzonerifolium Willd.；北柴胡Bupleurum chinense DC. |
| 化合物类型 | 萜类(Terpenoids)>三萜>齐墩果烷型五环三萜皂苷 |
| 化学式 | C42H68O13 |
| 分子量 | 780.98 |
| CAS号 | 20874-52-6 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | Water: < 0.1 mg/ml (insoluble); DMSO: 50 mg/ml (64.02 mM) |
| 溶液配制 | 10mg加入1.28ml DMSO，或者每7.81mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β. | ||||
| 信号通路 | MAPK; NF-κB; STAT3 | ||||
| 靶点 | P-selectin | MMP-1 | Estrogen Receptor-β | E-selectin | L-selectin |
| IC50 | 4.3 µM | 5 μM | - | 1.8 µM | 3.0 µM |
| 体外研究 | Saikosaponin D (Compound 3) is a triterpene saponin, which inhibits E-selectin, L-selectin and P-selectin binding to THP-1 cells, with IC50s of 1.8 µM, 3.0 µM and 4.3 µM, and such effects are not due to cytotoxic action. Saikosaponin D (1, 5, 10 µM) dose-dependently inhibits the THP-1 adhesion to the HUVECs monolayer activated by TNF-α. Saikosaponin D (30 μM) also inhibits the expression of P-selectin ligand (CD162) in THP-1 cells. Saikosaponin D (5 μM) suppresses the proliferation of HSC-T6 cells induced by H2O2 treatment, reduces the expression levels of α-SMA, TGF-β1, Hyp, COL1 and TIMP-1, and increases MMP-1 expressioon, thus inhibiting H2O2-induced excessive extracellular matrix (ECM) formation, with similar effects to estradiol (E2), and these effects are blocked by ER antagonists. Saikosaponin D also inhibits oxidative stress-induced ROS generation and down reduates MAPK signaling pathway, and the inhibition is also suppressed by ER antagonists. | ||||
| 体内研究 | Saikosaponin D (2 mg/kg/day, i.p.) shows a protective effect on overdose of acetaminophen (APAP)-induced liver injury of mice. Saikosaponin D affects APAP metabolism, increases GSH levels but does not alter PPARα activation. Saikosaponin D (2 mg/kg/day, i.p.) also suppresses APAP-induced increases in the expression of STAT3 target genes and pro-inflammatory cytokines and inhibits APAP-induced activation of STAT3 and NF-kB. | ||||
| 临床实验 | N/A | ||||
1. Jang MJ, et al. Molecules. 2014,19(12):20340-9.
2. Que R, et al. Int J Mol Med. 2018,41(3):1357-1364.
3. Liu A, et al. Chem Biol Interact. 2014,223:80-6.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6076-10mM | 柴胡皂苷D (98%, HPLC) | 10mM×0.2ml |
| SM6076-5mg | 柴胡皂苷D (98%, HPLC) | 5mg |
| SM6076-25mg | 柴胡皂苷D (98%, HPLC) | 25mg |
| SM6076-100mg | 柴胡皂苷D (98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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