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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM7040-10mM | 杯苋甾酮(98%, HPLC) | 10mM×0.2ml | 175.00元 |
| SM7040-5mg | 杯苋甾酮(98%, HPLC) | 5mg | 202.00元 |
| SM7040-25mg | 杯苋甾酮(98%, HPLC) | 25mg | 840.00元 |
| SM7040-100mg | 杯苋甾酮(98%, HPLC) | 100mg | 2856.00元 |
化学信息：
| 中文名 | 杯苋甾酮 |
| 英文名 | Cyasterone |
| 中文别名 | - |
| 英文别名 | - |
| 来源 | 川牛膝Cyathula officinalis Kuan；金疮小草Ajuga decumbens Thunb. |
| 化合物类型 | 甾体类(Steroids)>甾酮 |
| 化学式 | C29H44O8 |
| 分子量 | 520.65 |
| CAS号 | 17086-76-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 91 mg/mL (174.8 mM) |
| 溶液配制 | 10mg加入1.92ml DMSO，或者每5.21mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors. | ||||
| 信号通路 | Apoptosis; Cell Cycle; MAPK | ||||
| 靶点 | p-EGFR | p-MEK | p-mTOR | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Cyasterone exerts cytotoxicity on multiple cell lines: HeLa (IC50=77.24 μg/ml); HepG-2 (IC50=52.03 μg/ml); MCF-7 (IC50=82.07 μg/ml) and MCF-7 (IC50=82.07 μg/ml). And It has none cytotoxicity (IC50>400 μg/ml) on 3 types of carcinoma (HT-29, Caco-2, T47D) and 1 type of normal (NIH 3T3) cell lines. Cyasterone (0-60 μg/ml; 48 hours) causes a significantly decreasing of the cell proliferation. It inhibits cell growth as a dose-dependent manner, exhibits IC50 values of 38.50 μg/ml and 32.96 μg/ml, respectively. Cyasterone (0-60 μg/ml; 24 hours) decreases p-EGFR, p-MEK, and p-mTOR as a dose-dependent manner in A549 cells, it affects the MAPK signaling pathway activities. | ||||
| 体内研究 | Cyasterone (intraperitoneal injection; 5 mg/kg, 10 mg/kg and 15 mg/kg; 21 days) has anti-proliferation effect in vivo and inhibits MGC823 cells xenografted tumor growth in vivo with few changes in body weights. | ||||
| 临床实验 | N/A | ||||
1. Lu X, et al. Biomed Pharmacother. 2016,84:330-339.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM7040-10mM | 杯苋甾酮(98%, HPLC) | 10mM×0.2ml |
| SM7040-5mg | 杯苋甾酮(98%, HPLC) | 5mg |
| SM7040-25mg | 杯苋甾酮(98%, HPLC) | 25mg |
| SM7040-100mg | 杯苋甾酮(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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