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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM9052-10mM | 甘松新酮(98%, HPLC) | 10mM×0.2ml | 102.00元 |
| SM9052-5mg | 甘松新酮(98%, HPLC) | 5mg | 138.00元 |
| SM9052-25mg | 甘松新酮(98%, HPLC) | 25mg | 576.00元 |
| SM9052-100mg | 甘松新酮(98%, HPLC) | 100mg | 1958.00元 |
化学信息：
| 中文名 | 甘松新酮 |
| 英文名 | Nardosinone |
| 中文别名 | - |
| 英文别名 | - |
| 来源 | 甘松Nardostachys jatamansi DC. |
| 化合物类型 | 酮类(Ketones)>脂环酮 |
| 化学式 | C15H22O3 |
| 分子量 | 250.33 |
| CAS号 | 23720-80-1 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 46 mg/ml (183.8 mM) |
| 溶液配制 | 3mg加入1.20ml DMSO，或者每2.50mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances. | ||||
| 信号通路 | PI3K/Akt; MEK/ERK | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1. Li P, et al. Brain Res Dev Brain Res. 2003,145(2):177-83.
2. Du M , Huang K , Gao L , et al. Journal of Huazhong University of Science and Technology, 2013,33(6):822-826.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM9052-10mM | 甘松新酮(98%, HPLC) | 10mM×0.2ml |
| SM9052-5mg | 甘松新酮(98%, HPLC) | 5mg |
| SM9052-25mg | 甘松新酮(98%, HPLC) | 25mg |
| SM9052-100mg | 甘松新酮(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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