|
CAS Number
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Chemical Formula
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Molecular Weight
|
Purity
|
Grade
|
|
85622-93-1
|
C6H6N6O2
|
194.15
|
≥98%
|
Reagent grade
|
基本信息(General Information):
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Name (Chinese)
|
替莫唑胺
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|
|
Name (English)
|
Temozolomide
|
|
Specifications
|
Reagent grade, ≥98% (HPLC)
|
|
Synonym (Chinese)
|
3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺, 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺, 4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺, 8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮, NSC 362856
|
|
Synonym (English)
|
3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide; 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2
|
|
Beilstein Registry No
|
-
|
|
EINECS Number
|
-
|
|
MDL Number
|
MFCD00866492
|
|
UNSPSC Code
|
12352200
|
产品描述(Description):
|
Application
|
替莫唑胺已可用于分析胶质母细胞瘤细胞系的耐药机制15，16。
|
|
Biochem/physiol Actions
|
替莫唑胺是一种DNA甲基化剂和耐药修饰剂；抗肿瘤和抗血管生成。替莫唑胺诱导G2/M阻滞和凋亡，原理是其通过基因组DNA中一个甲基基团内收至鸟嘌呤的O6位置，以及碱基切除修复(BER)途径中DNA修复蛋白O(6)-烷基鸟嘌呤DNA烷基转移酶(AGT)的功能失活。
|
|
Preparation Note
|
替莫唑胺溶于DMSO，溶解浓度大于20 mg/ml。它不溶于水。
|
性质(Properties)：
|
assay
|
>=98% (HPLC)
|
|
storage temp.
|
2-8°C
|
|
solubility
|
DMSO: soluble10 mg/mL, clear
|
|
solubility
|
H2O: insoluble
|
|
form
|
powder
|
|
color
|
white to light brown
|
安全信息(Safety Information)：
|
Hazard Pictogram Codes
|
 
|
|
Signal Word
|
Danger
|
|
Hazard Statements
|
H302-H315-H319-H335-H350-H360
|
|
Precautionary Statements
|
P201-P261-P305 + P351 + P338-P308 + P313
|
|
Personal Protective Equipment
|
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
|
|
Hazard Codes (Europe)
|
T
|
|
Risk Codes (Europe)
|
45-46-60-61-22-36/37/38
|
|
Safety Codes (Europe)
|
53-26-36/37-45
|
|
RIDADR
|
NONH for all modes of transport
|
|
WGK Germany
|
3
|
|
RTECS
|
NJ5927050
|
|
Flash Point (F)
|
-
|
|
Flash Point (C)
|
-
|
包装清单:
|
产品编号
|
产品名称
|
包装
|
|
ST1695-5mg
|
替莫唑胺(≥98%, Reagent grade)
|
5mg
|
|
ST1695-25mg
|
替莫唑胺(≥98%, Reagent grade)
|
25mg
|
|
ST1695-100mg
|
替莫唑胺(≥98%, Reagent grade)
|
100mg
|
|
－
|
说明书
|
1份
|
保存条件:
4°C保存，三年有效。
注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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