使用说明：
1. U0126常见使用浓度范围为1-20μM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所
   培养的特定细胞和组织，通过实验进行摸索和优化。

使用本产品的文献：
1. Pu J, Peng G, Li L, Na H, Liu Y, Liu P.
   Palmitic acid acutely stimulates glucose uptake via activation of Akt and ERK1/2 in
   skeletal musclecells.
   J Lipid Res. 2011 Jul;52(7):1319-27.
2. Liang X, So YH, Cui J, Ma K, Xu X, Zhao Y, Cai L, Li W.
   The low-dose ionizing radiation stimulates cell proliferation via activation of the
   MAPK/ERKpathway in rat cultured mesenchymal stem cells.
   J Radiat Res. 2011;52(3):380-6.
3. Xie H, Hua C, Sun L, Zhao X, Fan H, Dou H, Sun L, Hou Y.
   17β-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in
   aminichromosome maintenance protein 6-dependent manner.
   Arthritis Rheum. 2011 Aug;63(8):2425-35.
4. Fang S, Jin Y, Zheng H, Yan J, Cui Y, Bi H, Jia H, Zhang H, Wang Y, Na L, Gao X, Zhou H.
   High glucose condition upregulated Txnip expression level in rat mesangial cells
   throughROS/MEK/MAPK pathway.
   Mol Cell Biochem. 2011 Jan;347(1-2):175-82. Epub 2010 Oct 19.
5. Ma J, Zhang L, Han W, Shen T, Ma C, Liu Y, Nie X, Liu M, Ran Y, Zhu D.
   Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis
   induced by EETin pulmonary artery endothelial cells.
   J Lipid Res. 2012 Jun;53(6):1093-105.
6. Zhu F, Shen F, Fan Y, Xie Y, Xia Y, Kong Y.
   Osteopontin increases the expression of β1, 4-Galactosyltransferase-I and promotes
   adhesion inhuman RL95-2 cells.
   Glycoconj J. 2012 Jul 31. [Epub ahead of print]
7. Zhao X, Liu L, Liu D, Fan H, Wang Y, Hu Y, Hou Y.
   Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via
   PGE2and IL-6.
   Am J Reprod Immunol. 2012 Jul 2. doi: 10.1111/j.1600-0897.2012.01163.x.
8. Zhou F, Chen S, Xiong J, Li Y, Qu L.
   Luteolin Reduces Zinc-Induced Tau Phosphorylation at Ser262/356 in an ROS-Dependent
   Manner inSH-SY5Y Cells.
   Biol Trace Elem Res. 2012 Apr 14.
9. Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G.
   The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit
   microglial activation.
   Sci Signal. 2012 Aug 21;5(238):ra61. doi: 10.1126/scisignal.2002946.
10. Zhou R, Yao X, Xu X, Wang G, Zhu Z, Chen J, Chen L, Shen X.
   Blockage of progesterone receptor effectively protects pancreatic islet beta cell
   viability.
   Steroids. 2013 Jul 1. pii: S0039-128X(13)00146-3.
11. Li L, Han M, Li S, Wang L, Xu Y.
   Cyclic Tensile Stress During Physiological Occlusal Force Enhances Osteogenic
   Differentiation of Human Periodontal Ligament Cells via ERK1/2-Elk1 MAPK Pathway.
   DNA Cell Biol. 2013 Jun 19.
12. Ye L, Shi Z, Liu H, Yang X, Wang K.
   GdCl3 induced Hep G2 cell death through mitochondrial and external death pathways
   without significantelevation of ROS generation.
   Biol Trace Elem Res. 2013 Jan;151(1):148-55. doi: 10.1007/s12011-012-9538-y.
   Epub 2012 Nov 6.
13. Li HJ, Guo LM, Yang LL, Zhou YC, Zhang YJ, Guo J, Xie XJ, Guo GZ.
   Electromagnetic-pulse-induced activation of p38 MAPK pathway and disruption of
   blood-retinal barrier.
   Toxicol Lett. 2013 Jun 20;220(1):35-43. doi: 10.1016/j.toxlet.2013.04.001.
   Epub 2013 Apr 6.
14. Wang S, Zhao Z, Bi Y, Sun L, Liu X, Liu W.
   Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus
   replication by controlling thenuclear import of M1.
   J Virol. 2013 Jun;87(11):6182-91. doi: 10.1128/JVI.03024-12. Epub 2013 Mar 27.
15. Zhang Z, Miao L, Lv C, Sun H, Wei S, Wang B, Huang C, Jiao B.
   Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling
   pathway in humanhepatoma SMMC-7721 cells.
   Cell Death Dis. 2013 Jun 6;4:e657. doi: 10.1038/cddis.2013.182.
16. Liu P, Wang YY, Qi X, Gu Q, Geng M, Li J.
   Undecylprodigiosin induced apoptosis in p388 cancer cells is associated with its binding
   to ribosome.
   PLoS One. 2013 Jun 14;8(6):e65381. doi: 10.1371/journal.pone.0065381. Print 2013.
17. Zhang X, Ding R, Zhou Y, Zhu R, Liu W, Jin L, Yao W, Gao X.
   Toll-like receptor 2 and Toll-like receptor 4-dependent activation of B cells by a
   polysaccharide from marinefungus Phoma herbarum YS4108.
   PLoS One. 2013;8(3):e60781. doi: 10.1371/journal.pone.0060781. Epub 2013 Mar 29.
18.Liu T, Yi W, Feng B, Zhou Z, Xiao G.
   IGF-1-induced enhancement of PRNP expression depends on the negative regulation of
   transcription factor FOXO3a.
   PLoS One. 2013 Aug 14;8(8):e71896. doi: 10.1371/journal.pone.0071896. eCollection
   2013.
19.Shen Y, Zhao Y, Zheng D, Chang X, Ju S, Guo L.
   Effects of orexin A on GLUT4 expression and lipid content via MAPK signaling in 3T3-L1
   adipocytes.
   J Steroid Biochem Mol Biol. 2013 Nov;138:376-83. doi: 10.1016/j.jsbmb.2013.07.005.
   Epub 2013 Jul 29.
20.Xue P, Wu X, Zhou L, Ma H, Wang Y, Liu Y, Ma J, Li Y.
   IGF1 promotes osteogenic differentiation of mesenchymal stem cells derived from rat bone
   marrow by increasing TAZ expression.
   Biochem Biophys Res Commun. 2013 Apr 5;433(2):226-31. doi: 10.1016/j.bbrc.2013.
   02.088. Epub 2013 Mar 5.
21.Shi R, Lin J, Guo Y, Gong YP.
   The MEK1/2 inhibitor U0126 reverses imatinib resistance through down-regulating
   activation of Lyn/ERK signaling pathway in imatinib-resistant K562R leukemia cells.
   Pharmazie. 2014 May;69(5):346-52.
22.Yuan H, Chen R, Wu L, Chen Q, Hu A, Zhang T, Wang Z, Zhu X.
   The Regulatory Mechanism of Neurogenesis by IGF-1 in Adult Mice.
   Mol Neurobiol. 2014 Apr 29.
23.Song MY, Yu JZ, Zhao DM, Wei S, Liu Y, Hu YM, Zhao WC, Yang Y, Wu H.
   The time-dependent manner of sinusoidal electromagnetic fields on rat bone marrow
   mesenchymal stem cells proliferation, differentiation, and mineralization.
   Cell Biochem Biophys. 2014 May;69(1):47-54. doi: 10.1007/s12013-013-9764-8.
24.Lin B, Xu Y, Zhang B, He Y, Yan Y, He MC.
   MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor
   function in rats following spinal cord injury.
   Exp Ther Med. 2014 Jan;7(1):66-72. Epub 2013 Oct 29.
25.Lv S1, Yi PF, Shen HQ, Zhang LY, Dong HB, Wu SC, Xia F, Guo X, Wei XB, Fu BD.
   Ginsenoside Rh2-B1 stimulates cell proliferation and IFN-γ production by activating the
   p38 MAPK and ERK-dependent signaling pathways in CTLL-2 cells.
   Immunopharmacol Immunotoxicol. 2014 Feb;36(1):43-51. doi: 10.3109/08923973.
   2013.864669. Epub 2013 Dec 3.
26.Liu Y, Mei C, Liu H, Wang H, Zeng G, Lin J, Xu M.
   Modulation of cytokine expression in human macrophages by endocrine-disrupting chemical
   Bisphenol-A.
   Biochem Biophys Res Commun. 2014 Sep 5;451(4):592-8. doi: 10.1016/j.bbrc.2014.08.
   031. Epub 2014 Aug 13.
27.Jiao S, Wu M, Ye F, Tang H, Xie X, Xie X.
   BikDDA, a mutant of Bik with longer half-life expression protein, can be a novel
   therapeutic gene for triple-negative breast cancer.
   PLoS One. 2014 Mar 17;9(3):e92172. doi: 10.1371/journal.pone.0092172. eCollection
   2014.
28.Wang Y, Liu D, Zhao H, Jiang H, Luo C, Wang M, Yin H.
   Cordyceps sinensis polysaccharide CPS-2 protects human mesangial cells from
   PDGF-BB-induced proliferation through the PDGF/ERK and TGF-β1/Smad pathways.
   Mol Cell Endocrinol. 2014 Feb 15;382(2):979-88. doi: 10.1016/j.mce.2013.11.018. Epub
   2013 Dec 2.
29.Shen M, Liu Z, Li B, Teng Y, Zhang J, Tang Y, Sun SC, Liu H.
   Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of
   apoptosis in mouse granulosa cells.
   Cell Death Dis. 2014 Oct 16;5:e1475. doi: 10.1038/cddis.2014.400.
30.Liu C, Li L, Ha M, Qi S, Duan P, Yang K.
   The PI3K/Akt and ERK pathways elevate thyroid hormone receptor β1 and TRH receptor to
   decrease thyroid hormones after exposure to PCB153 and p,p'-DDE.
   Chemosphere. 2015 Jan;118:229-38. doi: 10.1016/j.chemosphere.2014.09.023. Epub 2014
   Sep 29.