使用说明：
1. Wortmannin常见使用浓度范围为1-100μM。具体的最佳工作浓度请参考相关文献，或根据实验目的，
   以及所培养的特定细胞和组织，通过实验进行摸索和优化。

使用本产品的文献：
1. Kui L, Weiwei Z, Ling L, Daikun H, Guoming Z, Linuo Z, Renming H.
   Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat
   cardiomyocytes through the PI3K-Akt signaling pathway.
   Regul Pept. 2009 Jun 5;155(1-3):62-9.
2. Shi H, Feng JM.
   Aristolochic acid induces apoptosis of human umbilical vein endothelial cells in vitro
   bysuppressing PI3K/Akt signaling pathway.
   Acta Pharmacol Sin. 2011 Aug;32(8):1025-30.
3. Zhang Q, Huang WD, Lv XY, Yang YM.
   Puerarin protects differentiated PC12 cells from H₂O₂-induced apoptosis through the
   PI3K/Akt signalling pathway.
   Cell Biol Int. 2012 May 1;36(5):419-26.
4. Wen Q, Zhou L, Zhou C, Zhou M, Luo W, Ma L.
   Change in hepatocyte growth factor concentration promote mesenchymal stem
   cell-mediatedosteogenic regeneration.
   J Cell Mol Med. 2012 Jun;16(6):1260-73.
5. Yang C, Zhao T, Lin M, Zhao Z, Hu L, Jia Y, Xue Y, Xu M, Tang Q, Yang B, Rong R, Zhu T.
   Helix B surface peptide administered after insult of ischemia reperfusion improved renal
   function, structure and apoptosis through beta common receptor/erythropoietin receptor
   and PI3K/Akt pathway in a murine model.
   Exp Biol Med (Maywood). 2013 Jan 1;238(1):111-9. doi: 10.1258/ebm.2012.012185.
6. Zhao L, Zhang W, Chen M, Zhang J, Zhang M, Dai K.
   Aspirin Induces platelet apoptosis.
   Platelets. 2013 Jan 9.
7. Zheng C, Guo Q, Wu Z, Sun L, Zhang Z, Li C, Zhang X.
   Amphiphilic glycopolymer nanoparticles as vehicles for nasal delivery of peptides and
   proteins.
   Eur J Pharm Sci. 2013 May 3;49(4):474-482. doi: 10.1016/j.ejps.2013.04.027.
8. Shao L, Liu K, Huang F, Guo X, Wang M, Liu B.
   Opposite effects of quercetin, luteolin, and epigallocatechin gallate on insulin
   sensitivity under normal andinflammatory conditions in mice.
   Inflammation. 2013 Feb;36(1):1-14. doi: 10.1007/s10753-012-9514-x.
9. Wang J, Zhang Y, Weng W, Qiao Y, Ma L, Xiao W, Yu Y, Pan Q, Sun F.
   Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad
   ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability
   and carcinogenic property in liver cancer.
   J Biol Chem. 2013 Nov 22;288(47):33667-81. doi: 10.1074/jbc.M113.503292. Epub 2013 Oct
   2.
10.Wang M, Gao XJ, Zhao WW, Zhao WJ, Jiang CH, Huang F, Kou JP, Liu BL, Liu K.
   Opposite effects of genistein on the regulation of insulin-mediated glucose homeostasis
   in adipose tissue.
   Br J Pharmacol. 2013 Sep;170(2):328-40. doi: 10.1111/bph.12276.
11.Chen L, Miao Y, Chen L, Jin P, Zha Y, Chai Y, Zheng F, Zhang Y, Zhou W, Zhang J, Wen L,
   Wang M.
   The role of elevated autophagy on the synaptic plasticity impairment caused by CdSe/ZnS
   quantum dots.
   Biomaterials. 2013 Dec;34(38):10172-81. doi: 10.1016/j.biomaterials.2013.09.048. Epub
   2013 Oct 3.
12.Liu C, Yang J, Fu W, Qi S, Wang C, Quan C, Yang K.
   Coactivation of the PI3K/Akt and ERK signaling pathways in PCB153-induced NF-κB
   activation and caspase inhibition.
   Toxicol Appl Pharmacol. 2014 Jun 15;277(3):270-8. doi: 10.1016/j.taap.2014.03.027.
   Epub 2014 Apr 12.
13.Chen S, An FM, Yin L, Liu AR, Yin DK, Yao WB, Gao XD.
   Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end
   product-induced tau hyperphosphorylation.
   Neuroscience. 2014 Jan 3;256:137-46. doi: 10.1016/j.neuroscience.2013.10.038. Epub
   2013 Oct 30.
14.Xu M, Hu J, Zhao W, Gao X, Jiang C, Liu K, Liu B, Huang F.
   Quercetin differently regulates insulin-mediated glucose transporter 4 translocation
   under basal and inflammatory conditions in adipocytes.
   Mol Nutr Food Res. 2014 May;58(5):931-41. doi: 10.1002/mnfr.201300510. Epub 2013 Dec
   17.
15.Yang G, Zhang S, Gao F, Liu Z, Lu M, Peng S, Zhang T, Zhang F.
   Osteopontin enhances the expression of HOTAIR in cancer cells via IRF1.
   Biochim Biophys Acta. 2014 Sep;1839(9):837-48. doi: 10.1016/j.bbagrm.2014.06.020.
   Epub 2014 Jul 2.
16.Chen G, Zhao J, Yin Y, Wang B, Liu Q, Li P, Zhao L, Zhou H.
   C-type natriuretic peptide attenuates LPS-induced endothelial activation: involvement of
   p38, Akt, and NF-κB pathways.
   Amino Acids. 2014 Dec;46(12):2653-63. doi: 10.1007/s00726-014-1816-x. Epub 2014 Aug 6.
17.Liu C, Li L, Ha M, Qi S, Duan P, Yang K.
   The PI3K/Akt and ERK pathways elevate thyroid hormone receptor β1 and TRH receptor to
   decrease thyroid hormones after exposure to PCB153 and p,p'-DDE.
   Chemosphere. 2015 Jan;118:229-38. doi: 10.1016/j.chemosphere.2014.09.023. Epub 2014
   Sep 29.