碧云天生物技术-BeyoECL Moon (极超敏ECL化学发光试剂盒)(P0018FM)

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试剂> 多肽与蛋白> 蛋白检测> Western试剂

BeyoECL Moon (极超敏ECL化学发光试剂盒)

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产品编号: P0018FM

产品包装:500ml

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产品编号	产品名称	产品包装	产品价格
P0018FS	BeyoECL Moon (极超敏ECL化学发光试剂盒)	100ml	415.00元
P0018FM	BeyoECL Moon (极超敏ECL化学发光试剂盒)	500ml	1352.00元

碧云天生产的Western萤光检测试剂BeyoECL Moon是一种极超敏的以luminol为基础的ECL化学发光试剂盒，发光效果显著优于BeyoECL Star，可与二抗上偶联的辣根过氧化物酶(horseradish peroxidase, HRP)发生化学反应，发出萤光，从而可以通过用X光片压片或其它适当化学发光成像设备检测样品。
碧云天生产的Western萤光检测试剂目前共有三种，分别是P0018S/P0018M BeyoECL Plus、P0018AS/P0018AM BeyoECL Star和P0018FS/P0018FM BeyoECL Moon。常规的Western检测，优先推荐使用BeyoECL Star。对于丰度比较高的目的蛋白的检测，例如内参蛋白等的检测，推荐使用性价比更高的BeyoECL Plus。对于低丰度较难检测的目的蛋白，优先推荐使用检测灵敏度最高的BeyoECL Moon。但对于丰度适中的目的蛋白的检测，不太推荐使用BeyoECL Moon，因为使用BeyoECL Moon时由于检测灵敏度特别高，容易产生过曝的现象。
BeyoECL Moon灵敏度极高，Western blot检测效果与Thermo公司SuperSignal West Dura相当或略佳(参考图1)，化学发光效果在1小时内显著优于Thermo公司的SuperSignal West Dura，30分钟内发光效果可达SuperSignal West Dura的约1.8-3.6倍，BeyoECL Star的4.2-6.9倍(参考图2)。

图1. BeyoECL Moon和Thermo公司SuperSignal West Dura及碧云天的BeyoECL Star的Western blot的检测效果对比图。Western检测过程中仅发光试剂不同，其余完全相同。图中可见，碧云天的BeyoECL Star的检测灵敏度大约为SuperSignal West Dura的50%左右，而BeyoECL Moon的检测灵敏度与SuperSignal West Dura相当或略佳。

BeyoECL Moon的发光强度高。20微升25pg/μl辣根过氧化物酶标记IgG中，加入100微升碧云天的BeyoECL Moon工作液等三种不同的发光液后，在不同时间点通过化学发光仪(luminometer)检测化学发光。检测数据显示在1小时内BeyoECL Moon的发光效果总是最强的，BeyoECL Star和SuperSignal West Dura的发光比较稳定，但发光强度要弱不少(图2)。

图2. BeyoECL Moon和Thermo公司SuperSignal West Dura以及碧云天的BeyoECL Star的检测效果对比。相同量的HRP-IgG (500pg)，与发光试剂混合后至图中指定时间检测化学发光。图中可见BeyoECL Moon在1小时内发光效果显著优于SuperSignal West Dura和BeyoECL Star。

BeyoECL Moon的高灵敏度可以大大节省宝贵的样品以及非常昂贵的一抗和二抗的用量。同时必须注意适当减少一抗和二抗或样品的用量，以免获得过深的难以比较灰度的条带。
BeyoECL Moon非常稳定。BeyoECL Moon和BeyoECL Star一样，37℃水浴孵育30天，和4℃保存的试剂相比，对相同样品的检测效果无任何明显差异。
BeyoECL Moon的背景很低，对PVDF膜和硝酸纤维素膜均适用。PVDF膜(FFP24/FFP26/FFP28/FFP32/FFP33/FFP39)和硝酸纤维素膜(FFN02/FFN03/FFN08)可以向碧云天订购。

包装清单：

产品编号	产品名称	包装
P0018FM-1	BeyoECL Moon A液	250ml
P0018FM-2	BeyoECL Moon B液	250ml
—	说明书	1份

保存条件：

4℃避光保存，一年有效。37℃避光保存，一个月内有效。如果长期不用，可以-20℃避光保存，这样可以保存更长时间。

注意事项：

BeyoECL Moon A液和B液在吸取过程中必须要更换枪头，A液和B液相互污染后会导致A液或B液逐渐失效，影响后续的使用效果。
各溶液使用后，请盖紧瓶盖，以防失效。特别是B液，含有氧化剂，比较容易被还原而失效。
BeyoECL Moon的萤光持续时间很长，但开始反应后的20-30分钟内萤光更强一些，随后萤光会逐渐减弱，因此请注意充分利用这萤光较强的30分钟进行压片或成像。
当发现BeyoECL Moon的检测灵敏度过高而影响检测效果时，可以选择检测灵敏度较低一些的BeyoECL Star (P0018A)或
BeyoECL Plus (P0018S)，或者减少样品、一抗或二抗的用量。
BeyoECL Moon A液和B液均对人体有害，操作时请小心，并注意有效防护以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：

1. Western实验步骤可以参考碧云天的相关网页：http://www.beyotime.com/support/western.htm。
2. BeyoECL Moon工作液的配制：等体积混合适量BeyoECL Moon A液和B液，室温放置备用。工作液宜在临检测前配制。
3. Western二抗孵育后，并进行数次洗涤后，用WB专用镊子(FS035)将膜取出，用吸水纸略吸去过多的液体(切勿接触膜的蛋白面)，然后置于一洁净保鲜膜上。
4. 根据膜的大小，按每10平方厘米膜加1ml BeyoECL Moon工作液的比例，滴加BeyoECL Moon工作液到膜上，确保使工作液均匀覆盖在膜上，放置1-2分钟。
5. 取膜，弃BeyoECL Moon工作液，用吸水纸略吸去过多的液体。将膜放在两片保鲜膜中间，随后进行压片检测或化学发光成像仪检测。
6. 压片检测：将膜固定于片夹内。暗室内压片1分钟，立即显影定影，根据结果再调整压片时间。或直接分别压片30秒、1、3、5分钟，然后一起显影定影观察结果。
7. 化学发光成像仪检测：将膜放置到化学发光成像仪内，参考仪器说明书进行检测。

相关产品：

产品编号	产品名称	包装
P0018S	BeyoECL Plus (超敏ECL化学发光试剂盒)	100ml
P0018M	BeyoECL Plus (超敏ECL化学发光试剂盒)	500ml
P0018AS	BeyoECL Star (特超敏ECL化学发光试剂盒)	100ml
P0018AM	BeyoECL Star (特超敏ECL化学发光试剂盒)	500ml
P0018FS	BeyoECL Moon (极超敏ECL化学发光试剂盒)	100ml
P0018FM	BeyoECL Moon (极超敏ECL化学发光试剂盒)	500ml
P0019	显影定影试剂盒	各1加仑
P0020	显影定影试剂盒	各1升

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51. Gong L, Chang H, Xu H

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52. Sun H, Sun Y

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53. Wang W, Hao Y, Li F

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54. Luo J, Pan J, Jin Y, Li M, Chen M

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55. Yang X, Zhang C, Tie H, Luo J, Wang Y, Wu Q

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J Cell Biochem. 2020 Apr 121(4):2950-2961. (IF 4.237)

56. Zhen Zhu, Ruihua Yu, Chao Yang, Dong Li, Jiawei Wang, Wanli Yang, Yonghua Ji, Li Wang, Yaosheng Wang, Feng Jiang

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57. Weiping Shi, Danhua Ling, Feiyun Zhang, Xiaohui Fu, Danping Lai, Yanzhen Zhang

Curcumin promotes osteogenic differentiation of human periodontal ligament stem cells by inducting EGR1 expression

Arch Oral Biol. 2021 Jan;121:104958. doi: 10.1016/j.archoralbio.2020.104958. (IF 1.931)

58. Liu Hui-Heng, Wang Jun-Sheng, Lin Jin-Zhou, Sun Jia-Wei, Guo Jiu-Bing, Liu Zhifeng, Su Lei

LPS induced PCT production via TLR-4/NF-кB passway:it is the difference of G-/G+ bacteremia rats

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59. Xinjia Han, Chunfang Cai, Jiezhen Huang, Qiufen Li, Liu Huang, Qingshan Xuan, Jinying Yang

The intervention effect of nicotine on cervical fibroblast-myofibroblast differentiation in lipopolysaccharide-induced preterm birth model through activating the TGF-β1/Smad3 pathway

Biomed Pharmacother. 2021 Feb;134:111135. doi: 10.1016/j.biopha.2020.111135. (IF 4.545)

60. Chensheng Zhao, Fan Yang, Xiaona Wei, Jingwen Zhang

miR-139-5p upregulation alleviated spontaneous recurrent epileptiform discharge-induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the Notch pathway

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61. Zhi Yang, Weigang Wu, Pengcheng Ou, Minna Wu, Furong Zeng, Boping Zhou, Shipin Wu

MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3

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62. Liang Liang, Yage Zheng, Yinping Xie, Ling Xiao, Gaohua Wang

Oridonin ameliorates insulin resistance partially through inhibition of inflammatory response in rats subjected to chronic unpredictable mild stress

Int Immunopharmacol. 2021 Feb;91:107298. doi: 10.1016/j.intimp.2020.107298. (IF 3.943)

63. Yijiang Huang, Daosen Chen, Zijian Yan, Jingdi Zhan, Xinghe Xue, Xiaoyun Pan, Huachen Yu

LncRNA MEG3 Protects Chondrocytes From IL-1β-Induced Inflammation via Regulating miR-9-5p/KLF4 Axis

Front Physiol. 2021 Mar 11;12:617654. doi: 10.3389/fphys.2021.617654. (IF 3.367)

64. Xiyang Yang, Xingbing Li, Minghao Luo, Yongzheng Guo, Chang Li, Dingyi Lv, Zhe Cheng, Longxiang Huang, Fei-Fei Shang, Bi Huang, Jian Shen, Suxin Luo, Jianghong Yan

Tubeimoside I promotes angiogenesis via activation of eNOS-VEGF signaling pathway

J Ethnopharmacol. 2021 Mar 1;267:113642. doi: 10.1016/j.jep.2020.113642. (IF 3.69)

65. Sheng Li, Di Qi, Jia-Ni Li, Xin-Yu Deng, Dao-Xin Wang

Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3

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66. Danling Chen, LinLi Xu, Jinhua Wu, Haiying Liang, Yuemei Liang, Guocheng Liu

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67. Yong Zhang, Qiuyan Weng, Jianming Chen, Ming Li, Jinming Han

Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes

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68. Haoran Zhang, Shixuan Zhuo, Danni Song, Leyao Wang, Junyi Gu, Junyan Ma, Yang Gu, Minghui Ji, Meijuan Chen, Yuanyuan Guo

Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule

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69. Yan Zhang, Xiaomei Yang, Shuang Wang, Shuang Song, Xiudong Yang

Gentiopicroside prevents alcoholic liver damage by improving mitochondrial dysfunction in the rat model

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70. Kang Yang, Ruixue Xu, Weidong Le

Dopamine receptor D1 agonist inhibits glioblastoma via calpain‑mediated ER stress and mitochondrial dysfunction

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71. Xiang Li, Nan Yang, Qi Cheng, Han Zhang, Fen Liu, Yunxiao Shang

MiR-21-5p in Macrophage-Derived Exosomes Targets Smad7 to Promote Epithelial Mesenchymal Transition of Airway Epithelial Cells

J Asthma Allergy. 2021 May 18;14:513-524. doi: 10.2147/JAA.S307165.

72. Hongchao Gou, Zhibiao Bian, Rujian Cai, Pinpin Chu, Shuai Song, Yan Li, Zhiyong Jiang, Kunli Zhang, Dongxia Yang, Chunling Li

RIPK3-Dependent Necroptosis Limits PRV Replication in PK-15 Cells

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73. Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Shi

Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p

Biochem Pharmacol. 2021 Jun;188:114575. doi: 10.1016/j.bcp.2021.114575. (IF 4.96)

74. Jianqiang Ma, Yifan Wu, Ying He

Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic β-cell injury and insulin secretion by sponging miR-9-5p

J Bioenerg Biomembr. 2021 Jun;53(3):333-342. doi: 10.1007/s10863-021-09895-3. (IF 2.524)

75. Mingdong Yu, Chao Qin, Pei Li, Yingli Zhang, Ying Wang, Jing Zhang, Dedong Li, Huixing Wang, Yuechun Lu, Keliang Xie, Yang Yu, Yonghao Yu

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice

Int Immunopharmacol. 2021 Jun;95:107583. doi: 10.1016/j.intimp.2021.107583. (IF 3.943)

76. Jie Zheng, Na Tian, Fei Liu, Yidian Zhang, Jingfen Su, Yang Gao, Mingmin Deng, Linyu Wei, Jingwang Ye, Honglian Li, Jian-Zhi Wang

A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies

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77. Mengmeng Cai, Boxiang Du, Yanna Si, Juanjuan Miao, Jianyun Ge, Jiejie Zhang, Jie Song, Hongguang Bao

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Am J Transl Res. 2021 Jul 15;13(7):7538-7555. (IF 3.375)

78. Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

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79. Na Luo, Shiqin Liu, Xin Li, Yu Hu, Kejing Zhang

Circular RNA circHIPK3 promotes breast cancer progression via sponging MiR-326

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80. Yan Huang, Chenxu Zhao, Yezi Kong, Panpan Tan, Siqi Liu, Yaoquan Liu, Fangyuan Zeng, Yang Yuan, Baoyu Zhao, Jianguo Wang

Elucidation of the mechanism of NEFA-induced PERK-eIF2α signaling pathway regulation of lipid metabolism in bovine hepatocytes

J Steroid Biochem Mol Biol. 2021 Jul;211:105893. doi: 10.1016/j.jsbmb.2021.105893.

81. Longfa Kou, Xinyu Jiang, Yingying Tang, Xing Xia, Yingtao Li, Aimin Cai, Hailun Zheng, Hailin Zhang, Vadivel Ganapathy, Qing Yao, Ruijie Chen

Resetting amino acid metabolism of cancer cells by ATB0,+-targeted nanoparticles for enhanced anticancer therapy

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82. Ying Cheng, Shen Wu, Xuejing Yan, Qian Liu, Danting Lin, Jingxue Zhang, Ningli Wang

Human Pro370Leu Mutant Myocilin Induces the Phenotype of Open-Angle Glaucoma in Transgenic Mice

Cell Mol Neurobiol. 2023 Jul;43(5):2021-2033. doi: 10.1007/s10571-022-01280-x. (IF 3.606)

83. Yan Zhang, Haitao Li, Lianlian Song, Jianfei Xue, Xinyan Wang, Shuang Song, Shuang Wang

Polysaccharide from Ganoderma lucidum ameliorates cognitive impairment by regulating the inflammation of the brain-liver axis in rats

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84. Hong Zhang, Susu Wang, Yaqian Wang, Anxin Lu, Chunping Hu, Chonghuai Yan

DHA ameliorates MeHg‑induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway

Mol Med Rep. 2021 Aug;24(2):558. doi: 10.3892/mmr.2021.12197. (IF 2.1)

85. Ao Chen, Fan Yang, Jing Kuang, Yuan Xiong, Bo-Bin Mi, Ying Zhou, Jing-Jing Hu, Shu-Jun Song, Tao Wan, Zhong-Zhong Wan, Hong-Yang Huang, Xin-Run Li, Wen Song, Wen-Xiu Qiu

A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment

ACS Appl Mater Interfaces. 2021 Sep 29;13(38):45335-45345. doi: 10.1021/acsami.1c15025.

86. Xiaomei Li, Chen Li, Yuanqi Li, Cong Liu, Xue Liang, Ting Liu, Zhihua Liu

Sodium nitroprusside protects HFD induced gut dysfunction via activating AMPKα/SIRT1 signaling

BMC Gastroenterol. 2021 Oct 2;21(1):359. doi: 10.1186/s12876-021-01934-y. (IF 2.489)

87. Jing-Hua Song, Hong-Yan Jia, Tian-Peng Shao, Zhi-Bao Liu, Yuan-Ping Zhao

Hydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage

Exp Ther Med. 2021 Oct;22(4):1121. doi: 10.3892/etm.2021.10555. (IF 1.785)

88. Cai-Ying Hu, Qian-Ying Zhang, Jie-Hui Chen, Bin Wen, Wei-Jian Hang, Kai Xu, Juan Chen, Ben-Hong He

Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury

Curr Med Sci. 2021 Oct;41(5):936-943. doi: 10.1007/s11596-021-2374-6. (IF 1.273)

89. Yang Kang, Minghui Bai, Liling Deng, Linbo Fan, Xing Wang

MiRNA-21 Regulates Bronchial Epithelial Cell Proliferation by Activating Tgfβ1/Smad Signaling Pathway and Its Correlation with Asthma Severity in Children

Iran J Public Health. 2021 Oct;50(10):1973-1982. doi: 10.18502/ijph.v50i10.7497. (IF 1.291)

90. Wei Li, Yuanhong Li, Shengyu Cui, Jiayi Liu, Lijiao Tan, Hao Xia, Changjiang Zhang

Se alleviates homocysteine-induced fibrosis in cardiac fibroblasts via downregulation of lncRNA MEG3

Exp Ther Med. 2021 Nov;22(5):1269. doi: 10.3892/etm.2021.10704. (IF 1.785)

91. Yan Huang, Chenxu Zhao, Yaoquan Liu, Yezi Kong, Panpan Tan, Siqi Liu, Fangyuan Zeng, Yang Yuan, Xinwei Li, Guowen Liu, Baoyu Zhao, Jianguo Wang

NEFA Promotes Autophagosome Formation through Modulating PERK Signaling Pathway in Bovine Hepatocytes

Animals (Basel). 2021 Nov 28;11(12):3400. doi: 10.3390/ani11123400.

92. Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Jia

Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke

Biochem Biophys Res Commun. 2021 Nov 5;577:71-79. doi: 10.1016/j.bbrc.2021.09.004.

93. Liu-Jing Wen, Yue-Sheng Wang, Pei-Yi Tan

miR-515-5p inhibits the proliferation, migration and invasion of human breast cancer cells by targeting CBX4

Exp Ther Med. 2021 Nov;22(5):1328. doi: 10.3892/etm.2021.10763. (IF 1.785)

94. Bin Wang, Ping Yu, Wei Lin, Zhaohui Zhai

MicroRNA-21-5p Reduces Hypoxia/Reoxygenation-Induced Neuronal Cell Damage through Negative Regulation of CPEB3

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95. Yi Zhou, Zhi Tan, Hao Huang, Yonglian Zeng, Shilian Chen, Jie Wei, Guozhen Huang, Chaosi Qian, Guandou Yuan, Songqing He

Baicalein pre-treatment alleviates hepatic ischemia/reperfusion injury in mice by regulating the Nrf2/ARE pathway

Exp Ther Med. 2021 Dec;22(6):1380. doi: 10.3892/etm.2021.10816. (IF 1.785)

96. Jian Guan, Jinru Weng, Qiaosheng Ren, Chunbin Zhang, Liantao Hu, Wenjun Deng, Shizhen Lu, Xinyu Dong, Weidong Li, Yue Li, Weiqun Wang

Clinical significance and biological functions of chemokine CXCL3 in head and neck squamous cell carcinoma

Biosci Rep. 2021 Dec 22;41(12):BSR20212403. doi: 10.1042/BSR20212403.

97. Wen Jiang, Jun Zhang, Xudong Zhang, Chenghong Fan, Jinlong Huang

VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway

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98. Dehong Mao, Zhongmei He, Wei Xuan, Jiao Deng, Weichun Li, Xiaoying Fang, Linglong Li, Feng Zhang

Effect and mechanism of BDNF/TrkB signaling on vestibular compensation

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99. Huijie Fan, Yanrong Li, Mengying Sun, Wushuai Xiao, Lijuan Song, Qing Wang, Bo Zhang, Jiezhong Yu, Xiaoming Jin, Cungen Ma, Zhi Chai

Hyperoside Reduces Rotenone-induced Neuronal Injury by Suppressing Autophagy

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100. Manxiu Cao, Junhong Zhao, Lijie Du, Zixiu Chen, Lei Zhang, Xiang Liu, Jiaqi Cheng, Yongjing Yan, Cuiping Zhang, Haihong Li

The combination of hair follicle-specific marker LHX2 and co-expressed marker can distinguish between sweat gland placodes and hair placodes in rat

J Mol Histol. 2021 Dec;52(6):1225-1232. doi: 10.1007/s10735-021-10023-z. (IF 2.531)

101. Xiao-Yi Feng, Bi-Chun Chen, Jian-Chun Li, Jin-Mei Li, Hong-Mei Li, Xuan-Qin Chen, Dan Liu, Rong-Tao Li

Gansui-Banxia Decoction extraction inhibits MDSCs accumulation via AKT /STAT3/ERK signaling pathways to regulate antitumor immunity in C57bl/6 mice

Phytomedicine. 2021 Dec;93:153779. doi: 10.1016/j.phymed.2021.153779. (IF 4.268)

102. Yichao Zhang, Junhui Xu, Zhendong Qiu, Yongjun Guan, XiaoYi Zhang, Xin Zhang, Dongqi Chai, Chen Chen, Qinyong Hu, Weixing Wang

STK25 enhances hepatocellular carcinoma progression through the STRN/AMPK/ACC1 pathway

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103. Zheng Xu, Luwei Xu, Yuzheng Ge, Hongbin Sun, Jiageng Zhu, Quanliang Dou, Ruipeng Jia

Cabazitaxel suppresses the proliferation and promotes the apoptosis and radiosensitivity of castration-resistant prostate cancer cells by inhibiting PI3K/AKT pathway

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104. Xiao Fang, Shu-Fang Duan, Zhi-Yuan Hu, Jun-Jie Wang, Le Qiu, Fei Wang, Xu-Lin Chen

Inhibition of Matrix Metalloproteinase-8 Protects Against Sepsis Serum Mediated Leukocyte Adhesion

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105. Yang Li, Jinyan Shao, Jianfeng Song, Shuili Yu, Jiqin Wang, Keyu Sun

MiR-34a-3p suppresses pulmonary vascular proliferation in acute pulmonary embolism rat by targeting DUSP1

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106. Gang Yu, Wanjing Chen, Xianghua Li, Liang Yu, Yanyan Xu, Qiang Ruan, Yawei He, Yong Wang

TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2

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107. Wei V Zheng, Yaqin Li, Xianyi Cheng, Yanwei Xu, Tao Zhou, Dezhi Li, Yu Xiong, Shaobin Wang, Zaizhong Chen

Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells

J Cell Mol Med. 2022 Feb;26(3):840-854. doi: 10.1111/jcmm.17131. (IF 4.486)

108. Jianwei Xiao, Rongsheng Wang, Weijian Zhou, Xu Cai, Zhizhong Ye

[Retracted] Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis

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109. Xiaomin Xi, Jiting Wang, Yue Qin, Yilin You, Weidong Huang, Jicheng Zhan

The Biphasic Effect of Flavonoids on Oxidative Stress and Cell Proliferation in Breast Cancer Cells

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110. Mingzhu Yan, Suwei Jin, Yongguang Liu, Lisha Wang, Zhi Wang, Tianji Xia, Qi Chang

Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control

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111. Jiangnan Pei, Zhenzhen Liu, Chengjie Wang, Nan Chu, Lei Liu, Yao Tang, Haiyan Liu, Qianqian Xiang, Haidong Cheng, Mingqing Li, Weirong Gu

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

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112. Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing Wu

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol

Mol Neurobiol. 2022 Mar;59(3):1938-1953. doi: 10.1007/s12035-021-02684-4. (IF 4.5)

113. Min Xu, Liu Li, Hua Liu, Wei Lu, Xiaoyang Ling, Mingjie Gong

Rutaecarpine Attenuates Oxidative Stress-Induced Traumatic Brain Injury and Reduces Secondary Injury via the PGK1/KEAP1/NRF2 Signaling Pathway

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114. Hua Huang, Ruining Pan, Yue Zhao, Huan Li, Huiyu Zhu, Sijia Wang, Aamir Ali Khan, Juan Wang, Xinhui Liu

L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy

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115. Bin Shen, Haibin Ding, Yanyan Ye, Baozhen Luo

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116. Sha-Sha Yi, Jun-Jie Zou, Long Meng, Hou-Minji Chen, Zhong-Qiu Hong, Xiu-Fang Liu, Umar Farooq, Mo-Xian Chen, Zheng-Rong Lin, Wei Zhou, Li-Juan Ao, Xi-Quan Hu, Li-Li Niu

Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice

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117. Mengyuan Li, Hongwei Jiang, Shengjiang Chen, Yujin Ma

GATA binding protein 1 recruits histone deacetylase 2 to the promoter region of nuclear receptor binding protein 2 to affect the tumor microenvironment and malignancy of thyroid carcinoma

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118. Xin Xin, Lian Duan, Huimin Yang, Hang Yu, Yandong Bao, Dalin Jia, Nan Wu, Ying Qiao

miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1

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119. Cuicui Wu

β-catenin inhibitors ICG-001 and pyrvinium sensitize bortezomib-resistant multiple myeloma cells to bortezomib

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120. Shuyuan Li, Yue Li, Zexin Jiang, Cheng Hu, Ya Gao, Qishi Zhou

Efficacy of total flavonoids of Rhizoma drynariae on the blood vessels and the bone graft in the induced membrane

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121. Jia Xu, Xi Li, Purong Zhang, Jie Luo, Exian Mou, Shiwei Liu

miR-143-5p suppresses breast cancer progression by targeting the HIF-1α-related GLUT1 pathway

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122. Bin Wen, Kai Xu, Rui Huang, Teng Jiang, Jian Wang, Jiehui Chen, Juan Chen, Benhong He

Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke

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123. Aidong Yuan, Penghuan Wu, Zhinian Zhong, Zhengyan He, Wenhu Li

Long non-coding RNA Gm37494 alleviates osteoarthritis chondrocyte injury via the microRNA-181a-5p/GABRA1 axis

J Orthop Surg Res. 2022 Jun 10;17(1):304. doi: 10.1186/s13018-022-03202-5. (IF 1.777)

124. Lile Wang, Ruicheng Hu, Aiguo Dai

Curcumin Increased the Sensitivity of Non-Small-Cell Lung Cancer to Cisplatin through the Endoplasmic Reticulum Stress Pathway

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125. Xiaohui Gong, Xinhui Fan, Xinxin Yin, Tonghui Xu, Jiaxin Li, Jialin Guo, Xiangkai Zhao, Shujian Wei, Qiuhuan Yuan, Jiali Wang, Xuchen Han, Yuguo Chen

Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest

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126. Dayong Li, Guanlan Liu, Yundou Wu

RORA alleviates LPS-induced apoptosis of renal epithelial cells by promoting PGC-1α transcription

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127. Fan Zhang, Jingxing Li, Chengxiong Gu, Haibo Zhang

MiR-140-5p upregulation suppressed β-glycerophosphate-induced vascular smooth muscle cell calcification via targeting TLR4

Immunopharmacol Immunotoxicol. 2022 Jun;44(3):295-305. doi: 10.1080/08923973.2022.2043896.

128. Xin Ye, Mengyi Li, Wei Bian, Anting Wu, Ting Zhang, Junwei Li, Peng Zhou, Huairui Cui, Yu-Qiang Ding, Min Liao, Chenyou Sun

RBP-J deficiency promoted the proliferation and differentiation of CD133-positive cells in both in vitro and in vivo studies

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129. Lanyue Hu, Weiwei Zhang, Zheng Xiang, Yali Wang, Cheng Zeng, Xiaojie Wang, Chengning Tan, Yichi Zhang, Fengjie Li, Yanni Xiao, Luping Zhou, Jiuxuan Li, Chun Wu, Yang Xiang, Lixin Xiang, Xiaomei Zhang, Xueying Wang, Wuchen Yang, Maoshan Chen, Qian Ran, Zhongjun Li, Li Chen

EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity

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130. Tongxi Li, Junjie Bai, Yichao Du, Peng Tan, Tianxiang Zheng, Yifan Chen, Yonglang Cheng, Tianying Cai, Meizhou Huang, Wenguang Fu, Jian Wen

Thiamine pretreatment improves endotoxemia-related liver injury and cholestatic complications by regulating galactose metabolism and inhibiting macrophage activation

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131. Jiacui Liu, Ping Wang, Ben Huang, Qingyuan Cheng, Yiping Duan, Liangyue Chen, Tiantian Ma, Cuiwen Zhu, Dongxu Li, Wei Fan, Mingxia Yu

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132. Binfeng Liu, Chengyao Feng, Zhongyue Liu, Chao Tu, Zhihong Li

A novel necroptosis-related lncRNAs signature effectively predicts the prognosis for osteosarcoma and is associated with immunity

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133. Xiaocheng Li, Zhengxia Wei, Yuhong Chen

CXCL12 regulates bone marrow-derived endothelial progenitor cells to promote aortic aneurysm recovery

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134. Liang Liang, Hui Wang, Ying Hu, Hetao Bian, Ling Xiao, Gaohua Wang

Oridonin relieves depressive-like behaviors by inhibiting neuroinflammation and autophagy impairment in rats subjected to chronic unpredictable mild stress

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135. Xin Zhang, Li-Yan You, Ze-Yu Zhang, Dong-Xiao Jiang, Yu Qiu, Ye-Ping Ruan, Zhu-Jun Mao

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136. Zhen-Yu She, Meng-Fei Xu, Sun-Ying Jiang, Ya-Lan Wei

Kinesin-7 CENP-E is essential for chromosome alignment and spindle assembly of mouse spermatocytes

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137. Liping Zhang, Xin Zhang, Yilin Liu, Sanrong Wang, Gongwei Jia

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138. Bai Yu, Yanhua Zhao, Shichao Teng, Yongcheng Ni, Shunjuan Xu, Xiang Wu, Jing Zhang, Xiru Xu, Yuan Fang, Jun Shi, Biao Zhang

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139. Shuangxi Gong, Fengshuai Yang, Yuliang Song, Xinyu Wang, Yunquan Yang

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140. Junna Jiao, Zhuang Qian, Yurong Wang, Mei Liu, Liye Fan, Mengqing Liu, Zichen Hao, Junrong Jiao, Zhuangwei Lv

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141. Xiaoyong Chen, Ziwei Li, Shuaiwei Wang, Guangzhi Tong, Keyuan Chen, Yan Zhao

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142. Yubo Ma, Juan Chen, Hecheng Li, Fangshi Xu, Tie Chong, Ziming Wang, Liandong Zhang

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143. Chi Li, Yang-Jie Ru, Quan-Yue Lin, Guang-Chun Gao, Yu-Die Yang, Xiao-Qin Zhang, Jin-Lai Gao, Shi-Hui Liu, Chu-Wei Zheng, Lin Wang, Ya-Xin Zheng, Ji-Ming Wu

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144. Xiaoying Wang, Kai He, Linlin Ma, Lan Wu, Yan Yang, Yanfei Li

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145. Honglong Fang, Juan Chen, Jian Luo, Jianhua Hu, Danqiong Wang, Liang Lv, Weiwen Zhang

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146. Yun Liu, Shuo Li, Dandan Liu, Hong Wei, Xingzhi Wang, Fuling Yan

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147. Junmei Li, Lin Qi, Ziyang Diao, Mengyu Zhang, Bin Li, Yunyi Zhai, Mingyue Hao, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Brucella BtpB Manipulates Apoptosis and Autophagic Flux in RAW264.7 Cells

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148. Guangzhi Li, Dongmei Zhang, Shizhen Wang, Ni Jie, Yongting Qin

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149. Yueming Wang, Kaiyue Han, Zile Li, Xiaoxuan Tang, Chen Wang, Yaxuan Zhao, Hengchao Zhang, Ziran Geng, Jie Kong, Xiying Luan, Yanlian Xiong

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150. Hua Chang, Xue Zhang, Baixue Li, Xiangkai Meng

PARP1 Is Targeted by miR-519a-3p and Promotes the Migration, Invasion, and Tube Formation of Ovarian Cancer Cells

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151. Taiwei Wang, Jian Liu, Xuemiao Huang, Chuanqi Zhang, Mengyuan Shangguan, Junyu Chen, Shan Wu, Mengmeng Chen, Zhaoyun Yang, Shuhua Zhao

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152. Tianyu Zhang, Chuli Song, He Li, Yanru Zheng, Yingjiu Zhang

Different Extracellular β-Amyloid (1-42) Aggregates Differentially Impair Neural Cell Adhesion and Neurite Outgrowth through Differential Induction of Scaffold Palladin

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153. Zhenhua Wu, Yunpeng Bai, Yujuan Qi, Chao Chang, Yan Jiao, Yaobang Bai, Zhigang Guo

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154. Yuanyuan Cao, Fei Luo, Jia Peng, Zhenfei Fang, Qiming Liu, Shenghua Zhou

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155. Bingshan Zhang, Di Xu

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156. Yimin Xue, Jiuyun Zhang, Jun Ke, Lijuan Zeng, Kun Cheng, Xu Han, Falu Chen, Feng Chen

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157. Jiazhen Huang, Ying Zhao

E2F Transcription Factor 1 Activates FKBP Prolyl Isomerase 4 to Promote Angiogenesis in Cervical Squamous Cell Carcinoma Via the PI3K/AKT Signaling Pathway

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158. Zhuoxian Zhang, Qiuli Zhu, Siya Wang, Chao Shi

Epigallocatechin-3-gallate inhibits the formation of neutrophil extracellular traps and suppresses the migration and invasion of colon cancer cells by regulating STAT3/CXCL8 pathway

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159. Hongyan Liao, Jiagui Huang, Jie Liu, Huimin Zhu, Yue Chen, Xuemei Li, Jun Wen, Qin Yang

Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway

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160. Xiaofan Sun, Heng Meng, Jia Xiao, Fangshu Liu, Juan Du, Hui Zeng

Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation

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161. Wan Zheng, Tianfa Li, Junping Wei, Yani Yan, Shanshan Yang

Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression

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162. Tianying Cai, Junjie Bai, Peng Tan, Zhiwei Huang, Chen Liu, Ziming Wu, Yonglang Cheng, Tongxi Li, Yifan Chen, Jian Ruan, Lin Gao, Yichao DU, Wenguang Fu

Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway

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163. Weijie Xie, Yanqin Zeng, Yunqiu Zheng, Bin Cai

Activated AMPK Protects Against Chronic Cerebral Ischemia in Bilateral Carotid Artery Stenosis Mice

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164. Yue Chen, Jiagui Huang, Jie Liu, Huimin Zhu, Xuemei Li, Jun Wen, Mingfen Tian, Jiangxia Ren, Li Zhou, Qin Yang

Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14-3-3ζ

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165. Yurong Zhu, Jun Li, Tao Ba, Yuan Sun, Xiangyun Chang

RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway

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