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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SC0362-10mM | K252a (PKC抑制剂) | 10mM×0.2ml | 1088.00元 |
化学信息：
| 化学名 | (9S,10R,12R)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG-3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER |
|
| 简称 | K252a | |
| 别名 |
K 252; K 252a; K 252b; K 252c; K 252d; K-252; K-252a; K-252b; K-252c; K-252d; staurosporine aglycone; staurosporinone |
|
| 中文名 | 诺卡氏菌液 | |
| 化学式 | C27H21N3O5 | |
| 分子量 | 467.47 | |
| CAS号 | 99533-80-9; 97161-97-2 | |
| 纯度 | ≥98% | |
| 溶剂/溶解度 |
Water <1mg/ml; DMSO 20mg/ml; Ethanol <1mg/ml |
|
| 溶液配制 | SC0362-10mM用DMSO配制。 |
生物信息：
| 产品描述 | Originally isolated from the soil fungi Nocardiopisis sp., K252a is a staurosporine analog that inhibits various protein kinases through competition with the ATP binding site. K252a is a reversible cell-permeable, potent inhibitor of phosphorylase kinase (IC50=1.7nM), protein kinase A (PKA) (IC50=140nM), and protein kinase C (PKC) (IC50=470nM). K252a is also known to inhibit protein kinase G and CaM kinase II. K252a inhibits nerve growth factor induced Trk activation (IC50=3nM), as well as downstream signaling. K252a is reported to induce apoptosis and cell cycle arrest through cdc25 and cdc2 inhibition. | ||||
| 信号通路 | PKC Signaling | ||||
| 靶点 | PKA | PKC | phosphorylase kinase | － | － |
| IC50 | 140nM | 470nM | 1.7nM | － | － |
| 体外研究 | N/A | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SC0362-10mM | K252a (PKC抑制剂) | 10mM×0.2ml |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。
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