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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1022-10mM | 咖啡酸(98%, HPLC) | 10mM×0.2ml | 70.00元 |
| SM1022-25mg | 咖啡酸(98%, HPLC) | 25mg | 96.00元 |
| SM1022-100mg | 咖啡酸(98%, HPLC) | 100mg | 326.00元 |
| 中文名 | 咖啡酸 |
| 英文名 | Caffeic acid |
| 中文别名 | - |
| 英文别名 | 3,4-Dihydroxycinnamic acid |
| 来源 | 蒲公英Taraxacum mongolicum Hand.-Mazz.；柠檬Citrus limon (L.) Burm. f. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>苯丙酸类 |
| 化学式 | C9H8O4 |
| 分子量 | 180.16 |
| CAS号 | 331-39-5 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: 100 mg/mL (555.06 mM) Water: < 0.1 mg/mL (insoluble) |
| 溶液配制 | 2mg加入1.11ml DMSO，或者每1.80mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO). | ||||
| 信号通路 | - | ||||
| 靶点 | TRPV1 | 5-LO | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Caffeic acid has inhibitory effects on histamine-induced responses and the inhibitory effect of Caffeic acid is gradually increased when the concentration used for pretreatment is increased from 0.1 to 1 mM, similar to typical dose-dependent responses. Pretreatment of HEK293T-TRPV1 cells with 1 mM Caffeic acid results in significant inhibition of capsaicin-induced responses. When lower concentration of Caffeic acid is used, the inhibitory effect for capsaicin-induced responses is less evident. Calcium imaging experiments show that Caffeic acid incubation results in significant inhibition in histamine-sensitive dorsal root ganglion (DRG) neurons. Pretreatment with Caffeic acid (1 mM) results in a significant decrease in the percentage of responsive DRG neurons to histamine application from 12.5% to 2.1%. Pretreatment with 1 mM Caffeic acid dramatically blocks the allylisothiocyanate (AITC)-induced intracellular calcium increase in TRPA1-expressing cells. Caffeic acid is also able to block the AITC-induced activation of TRPA1. | ||||
| 体内研究 | Mice pretreated with Caffeic acid (500 mg/kg) exhibit significantly less histamine-induced scratching (30.50±10.87 bouts/1 h, n=6). It is further found that the lower dose of Caffeic acid (100 mg/kg) is not significantly effective in terms of anti-scratching effects in histamine-induced scratching, although there appears to be a tendency of reduction (49.40±12.35 bouts/1 h, n=5). The chloroquine induced scratching is significantly inhibited by pretreatment with 500 mg/kg of Caffeic acid (161.6±31.42 bouts/1 h, n=5).Caffeic acid significantly reduces the expression of 5-LO mRNA (P<0.01) dose-dependently in hippocampus. Compare with the ischemia-reperfusion (I/R) non-treated group, 5-LO protein expression is significantly reduced in the I/R-Caffeic acid group (P<0.05 or P<0.01), especially in the I/R-Caffeic acid group (50 mg/kg). Compare with the I/R non-treated group, the latency to find platform is significantly shortened in low- and high-dose Caffeic acid groups, the shortened platform latency is most evident in the I/R- Caffeic acid group (50 mg/kg) (P<0.01). In the low-dose Caffeic acid group, cell injury is still marked, the pyknosis ratio is (63.6±2.8)%, whereas in the high-dose Caffeic acid group, hippocampal neuron karyopyknosis is significantly reduced and the pyknosis ratio is (13.3±3.0)%. | ||||
| 临床实验 | NCT02556814: Immune Thrombocytopenia, Phase 4; NCT02351622: Immune Thrombocytopenia, Phase 3; NCT04648917: Esophagus Cancer, Stage III, Phase 3. | ||||
1.Pradhananga S, et al. Eur J Pharmacol. 2015,762:313-21.
2.Liang G, et al. Behav Brain Funct. 2015,11:18.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1022-10mM | 咖啡酸(98%, HPLC) | 10mM×0.2ml |
| SM1022-25mg | 咖啡酸(98%, HPLC) | 25mg |
| SM1022-100mg | 咖啡酸(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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