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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1047-10mM | 肉桂酸(98%, HPLC) | 10mM×0.2ml | 69.00元 |
| SM1047-25mg | 肉桂酸(98%, HPLC) | 25mg | 70.00元 |
| SM1047-100mg | 肉桂酸(98%, HPLC) | 100mg | 238.00元 |
| 中文名 | 肉桂酸 |
| 英文名 | Cinnamic acid |
| 中文别名 | - |
| 英文别名 | 3-Phenylacrylic acid; β-Phenylacrylic acid; Myricitrine; Phenylacrylic acid; Cinnamylic acid; Isocinnamic acid |
| 来源 | 苏合香树Liquidambar orientalis Mill. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>苯丙酸类 |
| 化学式 | C9H8O2 |
| 分子量 | 148.16 |
| CAS号 | 621-82-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
Ethanol: ≥ 50 mg/ml (337.47 mM) DMSO: 50 mg/ml (337.47 mM) |
| 溶液配制 | 2mg加入1.35ml DMSO，或者每1.48mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. | ||||
| 信号通路 | - | ||||
| 靶点 | Cancer Intervention | - | - | - | - |
| IC50 | 1-4.5 mM | - | - | - | - |
| 体外研究 | Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. 5 to 20 times more than for tumor cells. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1.Liu L, et al. Int J Cancer. 1995,62(3):345-50.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1047-10mM | 肉桂酸(98%, HPLC) | 10mM×0.2ml |
| SM1047-25mg | 肉桂酸(98%, HPLC) | 25mg |
| SM1047-100mg | 肉桂酸(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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