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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1138-10mM | 迷迭香酸(98%, HPLC) | 10mM×0.2ml | 84.00元 |
| SM1138-25mg | 迷迭香酸(98%, HPLC) | 25mg | 195.00元 |
| SM1138-100mg | 迷迭香酸(98%, HPLC) | 100mg | 663.00元 |
| 中文名 | 迷迭香酸 |
| 英文名 | Rosmarinic acid |
| 中文别名 | 迭香酸；酪萨维；罗丹酚酸；肉桂醇甙 |
| 英文别名 | Labiatenic acid |
| 来源 | 紫苏子Perilla frutescens (L.) Britt.；迷迭香Rosmarinus officinalis L. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>香豆素(Coumarins)>线型呋喃香豆素 |
| 化学式 | C18H16O8 |
| 分子量 | 360.31 |
| CAS号 | 20283-92-5 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/mL (277.54 mM) |
| 溶液配制 | 5mg加入1.39ml DMSO，或者每3.60mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment and cardioprotection. | ||||
| 信号通路 | - | ||||
| 靶点 | MAO-A | MAO-B | COMT | NF-κB | STAT3 |
| IC50 | 50.1 μM | 184.6 μM | 26.7 μM | - | - |
| 体外研究 | Rosmarinic acid (RA) shows an in vitro multifunctional profile characterized by antioxidant effects, and monoamine oxidases (MAO-A and MAO-B) and catechol-O-methyl transferase (COMT) inhibition. Rosmarinic acid shows antioxidant effects against hydroxyl (HO(•)) and nitric oxide (NO) radicals (IC50 of 29.4 and 140 μM, respectively), and inhibition of lipid peroxidation (IC50 of 19.6 μM). Rosmarinic acid (RA) exerts a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. In H2O2-treated cells, 2.5 μM Rosmarinic acid scavenges 60% of intracellular ROS compared to 77% of intracellular ROS scavenging effect in N-acetyl-L-cysteine (NAC). | ||||
| 体内研究 | Rosmarinic acid (RA) is a widespread phenolic ester compound in the plants, particularly those in the Labiatae family of herbs, such as Rosmarinus officinali, Salvia miltiorrhiza, and Prunella vulgaris. Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation. In the DSS-induced colitis model, Treatment with Rosmarinic acid (30, 60 mg/kg, p.o.) markedly attenuates the production of cytokines. | ||||
| 临床实验 | NCT00465543: Nasal Polyps, Phase 2; NCT01380015: Osteoarthritis of the Knee, Phase 4. | ||||
1.Andrade JM, et al. Chem Biol Interact. 2016,254:135-45.
2.Fernando PM, et al. Biomol Ther (Seoul). 2016,24(1):75-84.
3.Jin BR, et al. Sci Rep. 2017,7:46252.
4.Shim K S, et al. Nutrients. 2020, 12(7): 1927.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1138-10mM | 迷迭香酸(98%, HPLC) | 10mM×0.2ml |
| SM1138-25mg | 迷迭香酸(98%, HPLC) | 25mg |
| SM1138-100mg | 迷迭香酸(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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