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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1155-10mM | 补骨脂素(98%, HPLC) | 10mM×0.2ml | 74.00元 |
| SM1155-25mg | 补骨脂素(98%, HPLC) | 25mg | 180.00元 |
| SM1155-100mg | 补骨脂素(98%, HPLC) | 100mg | 612.00元 |
| 中文名 | 补骨脂素 |
| 英文名 | Psoralen |
| 中文别名 | 补骨脂内酯；补骨酯素 |
| 英文别名 | Ficusin |
| 来源 | 补骨脂Psoralea corylifolia Linn. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)＞香豆素类(Coumarins)>线型呋喃香豆素 |
| 化学式 | C11H6O3 |
| 分子量 | 186.16 |
| CAS号 | 66-97-7 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: 25 mg/mL (134.29 mM) Water: 1 mg/mL (5.37 mM; ultrasonic and warming and heat to 80°C) |
| 溶液配制 | 2mg加入1.07ml DMSO，或者每1.86mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Psoralen (10-500 μM; 24-48 hours) inhibits cell viability in a concentration- and time-dependent manner in L02 and HepG2 cells. In L02 cells, Psoralen at 400 μM does not significantly change extracellular LDH levels, and 400 μM or 450 μM psoralen inhibits 50–60% of cell viability. Psoralen (150-450 μM; 24 hours) induces significant S-phase arrest in L02 cells in time- and dose-dependent manners, but it does not exhibits significant change in the cycle distribution of HepG2 cells. | ||||
| 体内研究 | Psoralen (oral gavage; 17.5 mg/kg; 6 weeks) reduces the number of metastatic lesions and the rate of bone metastasis by 20% compared to vehicle-treated mice. It also reduces tumor infiltration and decreases the percentage of tumor cells in metastatic lesions by ~40% compared to vehicle in mice. | ||||
| 临床实验 | NCT00217009: Dermatitis|Psoriasis, Phase 1; NCT00005092: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes, Phase 1. | ||||
1.Li Yin, et al. Int J Mol Med. 2018,41(6):3727-3735.
2.Wu C, et al. Fitoterapia. 2013,91:205-10.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1155-10mM | 补骨脂素(98%, HPLC) | 10mM×0.2ml |
| SM1155-25mg | 补骨脂素(98%, HPLC) | 25mg |
| SM1155-100mg | 补骨脂素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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