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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2013-10mM | 新橙皮苷(98%, HPLC) | 10mM×0.2ml | 93.00元 |
| SM2013-25mg | 新橙皮苷(98%, HPLC) | 25mg | 180.00元 |
| SM2013-100mg | 新橙皮苷(98%, HPLC) | 100mg | 612.00元 |
| 中文名 | 新橙皮苷 |
| 英文名 | Neohesperidin |
| 中文别名 | 新桔皮苷；新橙皮甙；柑果苷 |
| 英文别名 | Hesperetin 7-neohesperidoside |
| 来源 | 枳壳橘Citrus reticulata Blanco；酸橙Citrus aurantium L. |
| 化合物类型 | 黄酮类(Flavonoids)>二氢黄酮 |
| 化学式 | C28H34O15 |
| 分子量 | 610.56 |
| CAS号 | 13241-33-3 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (163.78 mM) |
| 溶液配制 | 10mg加入1.64ml DMSO，或者每6.11mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Neohesperidin is a flavonoid compound found in high amounts in Poncirus trifoliata with anti-oxidant and anti-inflammatory effects. | ||||
| 信号通路 | Inflammation; Apoptosis | ||||
| 靶点 | P53 | Bax | Bcl-2 | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Neohesperidin induces cell apoptosis in human breast adenocarcinoma MDA-MB-231 cells. The IC50 values of neohesperidin at 24 and 48 h are 47.4±2.6 μM and 32.5±1.8 μM, respectively. The expressions of P53 and Bax in the neohesperidin-treated cells are significantly up-regulated, while that of Bcl-2 is down-regulated. Neohesperidin exhibits antioxidant activity (IC50=22.31 μg/ml) in the DPPH radical-scavenging assay. | ||||
| 体内研究 | Neohesperidin (50 mg/kg) significantly inhibits 55.0% of HCl/ethanol-induced gastric lesions. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreases the volume of gastric secretion and gastric acid output, and increases the pH. Treatment of neohesperidin significantly decreases fasting glucose, serum glucose, and glycosylated serum protein (GSP) in mice. It significantly elevates oral glucose tolerance and insulin sensitivity and decreases insulin resistance in the diabetic mice. Neohesperidin significantly decreases serum triglycerides, total cholesterol, leptin level, and liver index in the mice. | ||||
| 临床实验 | N/A | ||||
1.Lee JH, et al. Phytother Res. 2009,23(12):1748-53.
2.Xu F, et al. Nat Prod Commun. 2012,7(11):1475-8.
3.Jia S, et al. Food Funct. 2015,6(3):878-86.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2013-10mM | 新橙皮苷(98%, HPLC) | 10mM×0.2ml |
| SM2013-25mg | 新橙皮苷(98%, HPLC) | 25mg |
| SM2013-100mg | 新橙皮苷(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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