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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2089-25mg | 橙皮苷(98%, HPLC) | 25mg | 75.00元 |
| SM2089-10mM | 橙皮苷(98%, HPLC) | 10mM×0.2ml | 77.00元 |
| SM2089-100mg | 橙皮苷(98%, HPLC) | 100mg | 255.00元 |
| 中文名 | 橙皮苷 |
| 英文名 | Hesperidin |
| 中文别名 | 橙皮甙 |
| 英文别名 | Hesperetin 7-rutinoside |
| 来源 | 佛手Citrus medica L. var. sarcodactylis Swingle；橘Citrus reticulata Blanco |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮>二氢黄酮 |
| 化学式 | C28H34O15 |
| 分子量 | 610.56 |
| CAS号 | 520-26-3 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 33 mg/ml (54.05 mM) |
| 溶液配制 | 10mg加入1.64ml DMSO，或者每6.11mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | COX-2 | iNOS | MDA | Intracellular ROS | - |
| IC50 | 10-30 µM | 10-30 µM | 0.1 μg/ml | 0.1 μg/ml | - |
| 体外研究 | Hesperidin (5-200 µM; 24-72 h) induces potent cytotoxic effects in human osteosarcoma MG-63 cells. Hesperidin (5-150 µM; 48 h) induces early and late apoptosis in MG-63 cells. Hesperidin (10-30 µM) inhibits the activity of COX-2 and iNOS in a dose dependent manner in RAW 264.7 cells activated with LPS. Hesperidin (0.1 μg/ml; 2 h) decreases the formation of MDA and intracellular ROS, including chondrocyte apoptosis. | ||||
| 体内研究 | Hesperidin (5-80 mg/kg; 2 weeks) significantly suppresses MG-63 tumor growth in mice. Hesperidin (200 mg/kg; once daily for 28 d) markedly attenuates cartilage destruction and reduces IL-1β and TNF-α levels in a surgically-induced osteoarthritis (OA) rats. | ||||
| 临床实验 | NCT04358497: Pelvic Congestive Syndrome|Pelvic Varices|Venous Disease, Phase 4; NCT03471910: Venous Insufficiency, Phase 4. | ||||
1.Du GY, et, al. Oncol Lett. 2018,16(5):6299-6306.
2.Tejada S, et, al. Curr Med Chem. 2018,25(37):4929-4945.
3.Gao G, et, al. Med Sci Monit. 2018,24:9177-9186.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2089-10mM | 橙皮苷(98%, HPLC) | 10mM×0.2ml |
| SM2089-25mg | 橙皮苷(98%, HPLC) | 25mg |
| SM2089-100mg | 橙皮苷(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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