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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2147-10mM | 槲皮素(98%, HPLC) | 10mM×0.2ml | 74.00元 |
| SM2147-25mg | 槲皮素(98%, HPLC) | 25mg | 100.00元 |
| SM2147-100mg | 槲皮素(98%, HPLC) | 100mg | 340.00元 |
| 中文名 | 槲皮素 |
| 英文名 | Quercetin |
| 中文别名 | 栎精；槲皮黄素 |
| 英文别名 | Sophoretin; Meletin; Quercetol; Quertin; Ericin |
| 来源 | 杠板归Polygonum perfoliatum L.；槐Sophora japonica L. |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮>黄酮醇 |
| 化学式 | C15H10O7 |
| 分子量 | 302.24 |
| CAS号 | 117-39-5 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: ≥ 100 mg/ml (330.86 mM) Ethanol: 10 mg/ml (33.09 mM) |
| 溶液配制 | 5mg加入1.65ml DMSO，或者每3.02mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. | ||||
| 信号通路 | Autophagy; Mitophagy | ||||
| 靶点 | PI3Kδ | PI3Kδ | PI3Kβ | Src kinases | Akt1/2 |
| IC50 | 2.4 μM | 3.0 μM | 5.4 μM | - | - |
| 体外研究 | Quercetin is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. | ||||
| 体内研究 | Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth. | ||||
| 临床实验 | NCT02463357: Mountain Sickness, Phase 4; NCT04258410: Menopause Related Conditions, Phase 4; NCT04468139: Covid-19, Phase 4; NCT00913081: Flushing, Phase 4. | ||||
1.Leyre Navarro-Núñez, et al. Fitoterapia. 2010,81(2):75-80.
2.Yu XB, et al. Yao Xue Xue Bao. 1996,31(3):176-81.
3.Yang F, et al. PLoS One. 2015,10(5):e0128277.
4.Tao Liu, et al. Life Sci. 2020,257:118116.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2147-10mM | 槲皮素(98%, HPLC) | 10mM×0.2ml |
| SM2147-25mg | 槲皮素(98%, HPLC) | 25mg |
| SM2147-100mg | 槲皮素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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