微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2215-10mM | 槐角苷(98%, HPLC) | 10mM×0.2ml | 79.00元 |
| SM2215-25mg | 槐角苷(98%, HPLC) | 25mg | 120.00元 |
| SM2215-100mg | 槐角苷(98%, HPLC) | 100mg | 408.00元 |
| 中文名 | 槐角苷 |
| 英文名 | Sophoricoside |
| 中文别名 | - |
| 英文别名 | Genistein 4′-glucoside |
| 来源 | 槐Sophora japonica Linn. |
| 化合物类型 | 黄酮类(Flavonoids)>异黄酮 |
| 化学式 | C21H20O10 |
| 分子量 | 432.38 |
| CAS号 | 152-95-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 41.67 mg/ml (96.37 mM) |
| 溶液配制 | 5mg加入1.16ml DMSO，或者每4.32mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. | ||||
| 信号通路 | - | ||||
| 靶点 | Histamine | NF-κB | IL-8 | IL-6 | Ratio of Rel/p65 |
| IC50 | 50 μM | 50 μM | 50 μM | 50 μM | 50 μM |
| 体外研究 | The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner. | ||||
| 体内研究 | When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent. | ||||
| 临床实验 | N/A | ||||
1.Kim SJ, et al. Molecules. 2013,18(5):6113-27.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2215-10mM | 槐角苷(98%, HPLC) | 10mM×0.2ml |
| SM2215-25mg | 槐角苷(98%, HPLC) | 25mg |
| SM2215-100mg | 槐角苷(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
