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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM3041-10mM | 羟基茜草素(98%, HPLC) | 10mM×0.2ml | 95.00元 |
| SM3041-5mg | 羟基茜草素(98%, HPLC) | 5mg | 108.00元 |
| SM3041-25mg | 羟基茜草素(98%, HPLC) | 25mg | 450.00元 |
| SM3041-100mg | 羟基茜草素(98%, HPLC) | 100mg | 1530.00元 |
化学信息：
| 中文名 | 羟基茜草素 |
| 英文名 | Purpurin |
| 中文别名 | 1,2,4-三羟基蒽醌; 吡啉 |
| 英文别名 | Madder purple; Verantin; Oxylizarinic acid |
| 来源 | 茜草Rubia cordifolia L. |
| 化合物类型 | 醌类(Quinones)>蒽醌>茜草素型蒽醌 |
| 化学式 | C14H8O5 |
| 分子量 | 256.21 |
| CAS号 | 81-54-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 51 mg/ml (199.05 mM) |
| 溶液配制 | 5mg加入1.95ml DMSO，或者每2.56mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Purpurin is a natural anthraquinone compound from Rubia tinctorum L.. Purpurin has antidepressant-like effects. | ||||
| 信号通路 | - | ||||
| 靶点 | MAO-A | - | - | - | - |
| IC50 | 0.422μM | - | - | - | - |
| 体外研究 | Purpurin was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. A comparison of their chemical structures suggested the 4-hydroxy group of purpurin might play an important role in its inhibition of MAO-A. Purpurin is a potent, selective, reversible inhibitor of MAO-A, and that it be considered a new potential lead compound for development of novel reversible inhibitors of MAO-A (RIMAs). | ||||
| 体内研究 | Purpurin (Orally; 2, 6, 18 mg/kg for 3 weeks) exerts dose-dependently antidepressant-like effects on behavior and stress axis reactivity in adult male C57BL/6J mice (6-7 weeks old upon arrival). | ||||
| 临床实验 | N/A | ||||
1. Ma L, et al. Psychopharmacology (Berl). 2020,237(3):887-899.
2. Lee H W, et al. Bioorganic & Medicinal Chemistry Letters. 2017,27(5):1136-1140.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM3041-10mM | 羟基茜草素(98%, HPLC) | 10mM×0.2ml |
| SM3041-5mg | 羟基茜草素(98%, HPLC) | 5mg |
| SM3041-25mg | 羟基茜草素(98%, HPLC) | 25mg |
| SM3041-100mg | 羟基茜草素(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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