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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM2053-10mM | 芹菜素(98%, HPLC) | 10mM×0.2ml | 72.00元 |
| SM2053-25mg | 芹菜素(98%, HPLC) | 25mg | 96.00元 |
| SM2053-100mg | 芹菜素(98%, HPLC) | 100mg | 326.00元 |
| 中文名 | 芹菜素 |
| 英文名 | Apigenin |
| 中文别名 | 芹黄素;芹菜苷元 |
| 英文别名 | 4',5,7-Trihydroxyflavone; Apigenol; Natural Yellow 1 |
| 来源 | 天南星Arisaema heterophyllum Blume；芹菜Apium graveolens L. |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮 |
| 化学式 | C15H10O5 |
| 分子量 | 270.24 |
| CAS号 | 520-36-5 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
Water: <0.1 mg/ml (insoluble) DMSO: 100 mg/ml (370.04 mM) |
| 溶液配制 | 5mg加入1.85ml DMSO，或者每2.70mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM. | ||||
| 信号通路 | - | ||||
| 靶点 | CYP2C9 | - | - | - | - |
| IC50 | 2 μM | - | - | - | - |
| 体外研究 | Apigenin (4',5,7-Trihydroxyflavone) inhibits cytochrome P450 2C9 (CYP2C9) with a Ki of 2 μM in the CYP2C9 RECO system (a purified, reconstituted enzyme system containing recombinant human CYP2C9, P450 reductase, cytochrome b5, and liposomes). Apigenin inhibits the cell proliferation. The growth inhibition rate (IR) of 20, 40, and 80 μM of Apigenin is 38%, 71%, and 99% respectively on the 7thd. after exposure to Apigenin for 24 or 48 h, the clone formation of SGC-7901 cells is suppressed in a dose- and time-dependent manner. The cloning efficiency in 80 μM is 9.8% and 5% after treatment with Apigenin for 24 and 48 h, while in the control group it is 40.4% and 43.4%. | ||||
| 体内研究 | Apigenin (4',5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. Apigenin (125 mg/kg and 250 mg/kg) alleviates Adriamycin (ADR) (24 mg/kg)-induced myocardial injury. Apigenin inhibits serum aspartate amino transferase (AST) release. Apigenin reduces serum lactate dehydrogenase (LDH) release. Apigenin reduces serum creatine kinase (CK) contents. | ||||
| 临床实验 | NCT03526081: Healthy, Not Applicable; NCT04114916: Cholesterol, Not Applicable. | ||||
1.Si D, et al. Drug Metab Dispos. 2009,37(3):629-34.
2.Wu K, et al. World J Gastroenterol. 2005,11(29):4461-4.
3.Yu W, et al. Evid Based Complement Alternat Med. 2017,2017:2590676.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2053-10mM | 芹菜素(98%, HPLC) | 10mM×0.2ml |
| SM2053-25mg | 芹菜素(98%, HPLC) | 25mg |
| SM2053-100mg | 芹菜素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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