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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4008-10mM | 芥子碱硫氰酸盐(98%, HPLC) | 10mM×0.2ml | 89.00元 |
| SM4008-5mg | 芥子碱硫氰酸盐(98%, HPLC) | 5mg | 60.00元 |
| SM4008-25mg | 芥子碱硫氰酸盐(98%, HPLC) | 25mg | 250.00元 |
| SM4008-100mg | 芥子碱硫氰酸盐(98%, HPLC) | 100mg | 850.00元 |
化学信息：
| 中文名 | 芥子碱硫氰酸盐 |
| 英文名 | Sinapine thiocyanate |
| 中文别名 | - |
| 英文别名 | - |
| 来源 | 白芥Sinapis alba L.；芥Brassica juncea (L.) Czern. et Coss. |
| 化合物类型 | 生物碱(Alkaloids) |
| 化学式 | C17H24N2O5S |
| 分子量 | 368.45 |
| CAS号 | 7431-77-8 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 125 mg/ml (339.26 mM) |
| 溶液配制 | 5mg加入1.36ml DMSO，或者每3.68mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease. | ||||
| 信号通路 | - | ||||
| 靶点 | AChE | FRS2α | ERK1/2 | - | - |
| IC50 | - | 10-200 μM | 10-200 μM | - | - |
| 体外研究 | Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes. Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity. Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease. Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2. | ||||
| 体内研究 | Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. | ||||
| 临床实验 | N/A | ||||
1. Boulghobra D, et, al. Redox Biol. 2020,34:101554.
2. Li Y, et, al. Food Funct. 2019,10(6):3637-3649.
3. Guo Y, et al. Food Chem Toxicol. 2014,67:187-92.
4. Yates K, et, al. Food Chem. 2019,276:768-775.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4008-10mM | 芥子碱硫氰酸盐(98%, HPLC) | 10mM×0.2ml |
| SM4008-5mg | 芥子碱硫氰酸盐(98%, HPLC) | 5mg |
| SM4008-25mg | 芥子碱硫氰酸盐(98%, HPLC) | 25mg |
| SM4008-100mg | 芥子碱硫氰酸盐(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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