产品编号 | 产品名称 | 产品包装 | 产品价格 |
SM4040-10mM | 苦参碱(98%, HPLC) | 10mM×0.2ml | 72.00元 |
SM4040-25mg | 苦参碱(98%, HPLC) | 25mg | 90.00元 |
SM4040-100mg | 苦参碱(98%, HPLC) | 100mg | 306.00元 |
中文名 | 苦参碱 |
英文名 | Matrine |
中文别名 | 母菊碱 |
英文别名 | Sophoridine; Vegard; α-Matrine; Matridin-15-one; Matrinium |
来源 | 越南槐Sophora tonkinensis Gagnep.;苦参Sophora flavescens Alt. |
化合物类型 | 生物碱(Alkaloids)>喹诺里西啶类生物碱 |
化学式 | C15H24N2O |
分子量 | 248.36 |
CAS号 | 519-02-8 |
纯度 | 98%, HPLC |
溶剂/溶解度 |
Water:20 mg/ml (80.53 mM) DMSO:≥ 50 mg/ml (201.32 mM) |
溶液配制 | 3mg加入1.21ml DMSO,或者每2.48mg加入1ml DMSO,配制成10mM溶液。 |
产品描述 | Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist. | ||||
信号通路 | Autophagy | ||||
靶点 | κ-Opioid Receptor | u-Receptor | Ratio of Bcl-2/Bax protein | - | - |
IC50 | - | - | - | - | - |
体外研究 | Matrine significantly inhibited the in vitro and ex vivo growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells. Matrine induced the apoptosis in A549 and SMMC-7721 cells. Matrine markedly enhanced the anticancer activity of anticancer agent trichostatin A (the histone deacetylase inhibitor) by strongly reducing the viability and/or the ratio of Bcl-2/Bax protein in A549 cells. | ||||
体内研究 | The acute toxicity test of matrine indicated that the tolerable dose of matrine was above 80 mg/kg in Kunming mice, and the LD50 was 157.13 mg/kg. | ||||
临床实验 | N/A |
1.Zhang Y, et al. Cytotechnology. 2009,59(3):191-200.
2.Higashiyama K, et al. Biol Pharm Bull. 2005,28(5):845-848.
3.Wang XY, et al. Nanfang Yike Daxue Xuebao. 2010,30(9):2154-2155.
包装清单:产品编号 | 产品名称 | 包装 |
SM4040-10mM | 苦参碱(98%, HPLC) | 10mM×0.2ml |
SM4040-25mg | 苦参碱(98%, HPLC) | 25mg |
SM4040-100mg | 苦参碱(98%, HPLC) | 100mg |
- | 说明书 | 1份 |
-20℃保存,至少一年有效。固体粉末4℃保存,至少一个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。
注意事项:本产品可能对人体有一定的毒害作用,请注意适当防护,以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
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