微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4072-10mM | 盐酸胡芦巴碱(98%, HPLC) | 10mM×0.2ml | 74.00元 |
| SM4072-25mg | 盐酸胡芦巴碱(98%, HPLC) | 25mg | 180.00元 |
| SM4072-100mg | 盐酸胡芦巴碱(98%, HPLC) | 100mg | 612.00元 |
| 中文名 | 盐酸胡芦巴碱 |
| 英文名 | Trigonelline chloride |
| 中文别名 | 葫芦巴碱盐酸盐 |
| 英文别名 | Trigonelline hydrochloride |
| 来源 | 戎芦巴Trigonella foenum-graecum L. |
| 化合物类型 | 生物碱(Alkaloids)>哌啶类生物碱 |
| 化学式 | C7H8ClNO2 |
| 分子量 | 173.60 |
| CAS号 | 6138-41-6 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 3.57 mg/ml (20.56 mM) |
| 溶液配制 | 2mg加入1.15ml DMSO，或者每1.74mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1, antibacterial, and antifungal activities. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | Anti-HSV-1 | Caspase-3/9 | Bcl-2 | Bcl-XL | - |
| IC50 | - | - | - | - | - |
| 体外研究 | It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H2O2 can induce the necrosis and apoptosis along with H2O2. | ||||
| 体内研究 | Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats. | ||||
| 临床实验 | N/A | ||||
1.Ilavenil S, et al. Asian Pac J Trop Med. 2015,8(4):263-8.
2.Joanna Folwarczna, et al. Nutrients. 2016,8(3):133.
3.Ozçelik B, et al. Pharm Biol. 2011,49(4):396-402.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4072-10mM | 盐酸胡芦巴碱(98%, HPLC) | 10mM×0.2ml |
| SM4072-25mg | 盐酸胡芦巴碱(98%, HPLC) | 25mg |
| SM4072-100mg | 盐酸胡芦巴碱(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
