微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5104-10mM | 龙胆苦苷(98%, HPLC) | 10mM×0.2ml | 82.00元 |
| SM5104-25mg | 龙胆苦苷(98%, HPLC) | 25mg | 180.00元 |
| SM5104-100mg | 龙胆苦苷(98%, HPLC) | 100mg | 612.00元 |
| 中文名 | 龙胆苦苷 |
| 英文名 | Gentiopicroside |
| 中文别名 | 龙胆苦甙 |
| 英文别名 | Gentiopicrin |
| 来源 | 龙胆Gentiana scabra Bunge |
| 化合物类型 | 萜类(Terpenoids)>单萜>环烯醚萜苷 |
| 化学式 | C16H20O9 |
| 分子量 | 356.32 |
| CAS号 | 20831-76-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 100 mg/ml (280.65 mM) |
| 溶液配制 | 5mg加入1.40ml DMSO，或者每3.56mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects. | ||||
| 信号通路 | Inflammation | ||||
| 靶点 | CYP2A6 | CYP2E1 | - | - | - |
| IC50 | 61 µM | 1.6 mM | - | - | - |
| 体外研究 | Gentiopicroside inhibits P450 activity, with an IC50 and a Ki of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption. | ||||
| 体内研究 | Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice. | ||||
| 临床实验 | N/A | ||||
1.Deng Y, et al. Drug Metab Pharmacokinet. 2013,28(4):339-44.
2.Yang Y, et al. Phytother Res. 2018,32(2):259-266.
3.Chen F, et al. Biomed Pharmacother. 2018,100:142-146.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5104-10mM | 龙胆苦苷(98%, HPLC) | 10mM×0.2ml |
| SM5104-25mg | 龙胆苦苷(98%, HPLC) | 25mg |
| SM5104-100mg | 龙胆苦苷(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
