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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5136-10mM | 栀子苷(98%, HPLC) | 10mM×0.2ml | 75.00元 |
| SM5136-25mg | 栀子苷(98%, HPLC) | 25mg | 96.00元 |
| SM5136-100mg | 栀子苷(98%, HPLC) | 100mg | 326.00元 |
| 中文名 | 栀子苷 |
| 英文名 | Geniposide |
| 中文别名 | 京尼平苷；京尼平甙；栀子甙；去羟基栀子甙；栀子苷 |
| 英文别名 | Genipin 1-glucoside; Jasminoidin |
| 来源 | 栀子Gardenia jasminoides Ellis |
| 化合物类型 | 萜类(Terpenoids)>单萜>环烯醚萜苷 |
| 化学式 | C17H24O10 |
| 分子量 | 388.37 |
| CAS号 | 24512-63-8 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (257.49 mM) |
| 溶液配制 | 5mg加入1.29ml DMSO，或者每3.88mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Geniposide is an iridoid glucoside extracted from Gardenia jasminoides Ellis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities. | ||||
| 信号通路 | - | ||||
| 靶点 | Amyloid-β | IL-8 | IL-1β | MCP-1 | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Geniposide exhibits a variety of activities, such as on antithrombosis, anti-inflammation, anti-diabetes, anti-atherosclerosis, antidepression, healing Alzheimer’s disease (AD), anti-hypertension, toxicology, and untoward reaction are summarized. Geniposide markedly declines the production of IL-8, IL-1β and MCP-1 in OGD-induced brain microvascular endothelial cells, the expression of P2Y14 receptor is significantly down-regulated, the phosphorylation of RAF-1, MEK1/2, ERK1/2 are suppressed. | ||||
| 体内研究 | Geniposide (200 and 400 mg/kg) significantly decreases the blood glucose, insulin and TG levels in diabetic mice in a dose-dependent manner. This compound also decreases the expression of GP and G6Pase at mRNA and immunoreactive protein levels, as well as enzyme activity. Geniposide (20.0, 40.0, or 80 mg/kg) significantly reverses the excessive, alcohol-induced elevation in both serum ALT/AST and hepatic LPO levels. Geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons. Geniposide inhibits photochemistry-induced thromboembolism model in vivo. Geniposide are very effective depressants on NF-κB by interrupting IκB degradation. | ||||
| 临床实验 | N/A | ||||
1.Liu H, et al. J Asian Nat Prod Res. 2013,15(1):94-110.
2.Li F, et al. J Ethnopharmacol. 2016,185:77-86.
3.Wu SY, et al. Acta Pharmacol Sin. 2009,30(2):202-8.
4.Wang J, et al. Can J Physiol Pharmacol. 2015,93(4):261-7.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5136-10mM | 栀子苷(98%, HPLC) | 10mM×0.2ml |
| SM5136-25mg | 栀子苷(98%, HPLC) | 25mg |
| SM5136-100mg | 栀子苷(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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