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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6044-10mM | 三七皂苷R1 (98%, HPLC) | 10mM×0.2ml | 108.00元 |
| SM6044-25mg | 三七皂苷R1 (98%, HPLC) | 25mg | 180.00元 |
| SM6044-100mg | 三七皂苷R1 (98%, HPLC) | 100mg | 612.00元 |
| 中文名 | 三七皂苷R1 |
| 英文名 | Notoginsenoside R1 |
| 中文别名 | - |
| 英文别名 | Sanchinoside R1; Sanqi glucoside R1 |
| 来源 | 三七Panax notoginseng (Burkill) F. H. Chen ex C. H. |
| 化合物类型 | 萜类(Terpenoids)>三萜>达玛烷型四环三萜皂苷 |
| 化学式 | C47H80O18 |
| 分子量 | 933.13 |
| CAS号 | 80418-24-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 100 mg/mL (107.17 mM) |
| 溶液配制 | 10mg加入1.01ml DMSO，或者每9.33mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells. | ||||
| 信号通路 | - | ||||
| 靶点 | Ischemia/Reperfusion (I/R) Injury | Oxidative Damage | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Notoginsenoside R1 (2.5-80 μM; 24 h) inhibits the hypoxia-reoxygenation (H/R)-induced cell death, intracellular ROS accumulation, and mitochondrial membrane depolarization in H9c2 cardiomyocytes. Notoginsenoside R1 (5-20 μM; 24 h) inhibits the H/R-induced H9c2 cardiomyocytes apoptosis in a concentration-dependent manner. Notoginsenoside R1 (1-100 μM; 24 h) dose-dependently protects PC12 cells and primary neurons from Aβ-induced cell death and apoptosis. Notoginsenoside R1 (10 μM; 24 h) inhibits Aβ25-35-induced ROS production, mitochondrial damage and MAPK activation in PC12 cells. | ||||
| 体内研究 | Notoginsenoside R1 (5 mg/kg/h; infused via the right jugular vein) increases red blood cell velocity, reduces the number of adherent leukocytes and inhibits mast cell degranulation and cytokine elevation in rats. | ||||
| 临床实验 | N/A | ||||
1.Yu Y, et, al. Sci Rep. 2016，6:21730.
2.Ma B, et, al. Int Immunopharmacol. 2014，22(1):151-9.
3.Sun K, et, al.Life Sci. 2007，81(6):509-18.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6044-10mM | 三七皂苷R1 (98%, HPLC) | 10mM×0.2ml |
| SM6044-25mg | 三七皂苷R1 (98%, HPLC) | 25mg |
| SM6044-100mg | 三七皂苷R1 (98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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