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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6092-10mM | 甘草酸(98%, HPLC) | 10mM×0.2ml | 97.00元 |
| SM6092-25mg | 甘草酸(98%, HPLC) | 25mg | 150.00元 |
| SM6092-100mg | 甘草酸(98%, HPLC) | 100mg | 510.00元 |
| 中文名 | 甘草酸 |
| 英文名 | Glycyrrhizic acid |
| 中文别名 | 18β,20β-甘草酸；甘草皂甙；甘草甜素；强力宁；甘草皂苷 |
| 英文别名 | Glycyrrhizinic acid; Dermacrin; Glycyrrhitin; Glycyrrhizin |
| 来源 | 甘草Glycyrrhiza uralensis Fisch |
| 化合物类型 | 萜类(Terpenoids)>三萜>齐墩果烷型五环三萜皂苷 |
| 化学式 | C42H62O16 |
| 分子量 | 822.93 |
| CAS号 | 1405-86-3 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | Water: < 0.1 mg/ml (insoluble); DMSO: ≥ 100 mg/ml (121.52 mM) |
| 溶液配制 | 10mg加入1.22ml DMSO，或者每8.23mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities. | ||||
| 信号通路 | - | ||||
| 靶点 | HMGB1 | TGR5 | GLP-1 | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Glycyrrhizic acid shows a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems. In intestinal NCI-H716 cells that secretes GLP-1, Glycyrrhizic acid promotes GLP-1 secretion with a marked elevation of calcium levels. Glycyrrhizic acid can enhance GLP-1 secretion through TGR5 activation. Glycyrrhizic acid can form a stable transparent low-molecular-weight hydrogels (LMWHs) at 37°C in physiological phosphate buffered saline (PBS) with nanoclusters as the microstructures. | ||||
| 体内研究 | In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), Glycyrrhizic acid increases the level of plasma GLP-1, which is blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5). Glycyrrhizic acid (Glycyrrhizic acid; 50 mg/kg, i.p.) significantly decreases the levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β in mice. | ||||
| 临床实验 | NCT04028869: Autoimmune Liver Disease | ||||
1.Su X, et al. Biomed Pharmacother. 2017,95:670-678.
2.Wang LY, et al. Biomed Pharmacother. 2017,95:599-604.
3.Li C, et al. Thyroid. 2017,27(5):722-731.
4.Xia Zhao, et al. ACS Appl. Bio Mater. 2020,3,1,648–653.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6092-10mM | 甘草酸(98%, HPLC) | 10mM×0.2ml |
| SM6092-25mg | 甘草酸(98%, HPLC) | 25mg |
| SM6092-100mg | 甘草酸(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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