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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6120-10mM | 土贝母苷甲(98%, HPLC) | 10mM×0.2ml | 106.00元 |
| SM6120-25mg | 土贝母苷甲(98%, HPLC) | 25mg | 120.00元 |
| SM6120-100mg | 土贝母苷甲(98%, HPLC) | 100mg | 408.00元 |
| 中文名 | 土贝母苷甲 |
| 英文名 | Tubeimoside I |
| 中文别名 | 土贝母皂甙甲 |
| 英文别名 | Tubeimoside-1; Lobatoside-H |
| 来源 | 土贝母Bolbostemma paniculatum（Maxim.） Franquet |
| 化合物类型 | 萜类(Terpenoids)>三萜>齐墩果烷型五环三萜皂苷 |
| 化学式 | C63H98O29 |
| 分子量 | 1319.44 |
| CAS号 | 102040-03-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO : ≥ 100 mg/ml (75.79 mM) |
| 溶液配制 | 15mg加入1.14ml DMSO，或者每13.19mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Tubeimoside I(Lobatoside-H) is an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM.) FRANQUET (Cucurbitaceae) has been shown as a potent anti-tumor agent for a variety of human cancers. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | Bcl-2 | Bax | Capase-3 | TNF-α | IL-6/1β |
| IC50 | - | - | - | - | - |
| 体外研究 | TBMS I inhibited the proliferation of both HepG2 and L-02 cells in a dose- and time-dependent manner, but HepG2 cells appeared more sensitive to the agent. When exposed to TBMS I for 24, 48 and 72 h, IC50 for HepG2 cells versus L-02 cells were 15.5 vs. 23.1, 11.7 vs. 16.2, 9.2 vs. 13.1 (μM, p<0.01), respectively. TBMS I induced cell shrinkage, nuclear condensation and fragmentation, cell cycle arrest at the G2/M phase, mitochondrial membrane disruption, release of cytochrome c from the mitochondria, activation of caspase 3 and 9, and shifting Bax/Bcl-2 ratio from being anti-apoptotic to pro-apoptotic, all indicative of initiation and progression of apoptosis involving mitochondrial dysfunction. TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest. TBMS1 combined with CDDP promoted cell apoptosis, decreased proliferation activity and increased cytosolic Ca2+ levels. Bcl-2 protein expression was down-regulated but Bax was up-regulated. Moreover, GST-π mRNA and protein expression were decreased. TBMS1 reduced the resistance of the cells to CDDP-induced cytotoxicity. Treatment with TBMS1 resulted in dose- and time-dependent inhibition of proliferation, led to arrest in phase G2/M of the cell cycle and increased the levels of intracellular Ca2 . Furthermore, TBMS1 up-regulated the levels of the glucose-regulated protein 78/immunoglobuin heavy chain binding protein (GRP78/Bip), C/EBP homologous protein (CHOP), Bax, and cleaved caspase-3 and down-regulated the levels of Bcl-2. | ||||
| 体内研究 | TBMS1 significantly inhibited the production of the pro-inflammatory cytokines, TNF-α, IL-6 and IL-1β in vitro and in vivo. Pretreatment with TBMS1 markedly attenuated the development of pulmonary edema, histological severities and inflammatory cells infiltration in mice with ALI. | ||||
| 临床实验 | N/A | ||||
1.Wang Y, et al. Biol Pharm Bull. 2011,34(6):831-8.
2.Xu Y, et al. Chin J Cancer Res. 2013,25(3):312-21.
3.Wu Q, et al. Immunopharmacol Immunotoxicol. 2013,35(4):514-23.
4.Liu HZ, et al. Mol Med Rep. 2011,4(5):985-92.
5.Chen WJ, et al. Int J Oncol. 2012,40(2):535-43.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6120-10mM | 土贝母苷甲(98%, HPLC) | 10mM×0.2ml |
| SM6120-25mg | 土贝母苷甲(98%, HPLC) | 25mg |
| SM6120-100mg | 土贝母苷甲(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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