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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM8056-10mM | 原儿茶酸(98%, HPLC) | 10mM×0.2ml | 68.00元 |
| SM8056-25mg | 原儿茶酸(98%, HPLC) | 25mg | 60.00元 |
| SM8056-100mg | 原儿茶酸(98%, HPLC) | 100mg | 204.00元 |
| 中文名 | 原儿茶酸 |
| 英文名 | Protocatechuic acid |
| 中文别名 | 3,4-二羟基苯甲酸 |
| 英文别名 | Carbohydroquinonic acid; Catechol-4-carboxylic acid; Hypogallic acid |
| 来源 | 金毛狗脊Cibotium barometz (L.) J. Sm. |
| 化合物类型 | 酚类(Phenols) |
| 化学式 | C7H6O4 |
| 分子量 | 154.12 |
| CAS号 | 99-50-3 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
Water: 10 mg/ml (64.88 mM); DMSO: 50 mg/ml (324.42 mM) |
| 溶液配制 | 3mg加入1.95ml DMSO，或者每1.54mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect. | ||||
| 信号通路 | - | ||||
| 靶点 | Aβ | αS | BChE | MDA | - |
| IC50 | - | - | 10−20 mg/kg | 10−20 mg/kg | - |
| 体外研究 | Protocatechuic acid inhibits the aggregation of Aβ and αS and destabilizes their preformed fibrils. Protocatechuic acid prevents the death of PC12 cells triggered by Aβ- and αS-induced toxicity. | ||||
| 体内研究 | Protocatechuic acid is able to prevent stress induced immobility time in forced swim test without altering locomotor activity in mice. Further, Protocatechuic acid treatment attenuates the elevation of serum corticosterone, lipid peroxidation and restores enzymatic antioxidants in cerebral cortex and hippocampus in ARS mice. Rat administered cadmium and treated with prostigmine and doses of Protocatechuic acid (10−20 mg/kg) has significantly reduced BChE activity. Cadmium and either prostigmine or Protocatechuic acid (10−20 mg/kg) treated rats shows significant reduction in MDA level. | ||||
| 临床实验 | N/A | ||||
1.Thakare VN, et al. Metab Brain Dis. 2017,32(2):401-413.
2.Adefegha SA, et al. Biomed Pharmacother. 2016,83:559-568.
3.Hornedo-Ortega R, et al. J Agric Food Chem. 2016,64(41):7722-7732.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM8056-10mM | 原儿茶酸(98%, HPLC) | 10mM×0.2ml |
| SM8056-25mg | 原儿茶酸(98%, HPLC) | 25mg |
| SM8056-100mg | 原儿茶酸(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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