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L-NAME(eNOS抑制剂) |
产品编号: S0006
产品包装: 200mg
产品价格: 125.00元 |
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产品简介
产品简介:
L-NAME,即NG-Nitro-L-arginine Methyl Ester, Hydrochloride,也称L-NAME, HCl或Nω-NO2-L-Arg-OMe或NG-NO2-L-Arg-OMe,是eNOS(endothelial nitric oxide synthase)的可逆抑制剂,IC50=500nM。高浓度L-NAME(例如100μM或更高浓度)也可以显著抑制iNOS和nNOS。
L-NAME为接近白色的粉末,分子量269.7,分子式为C7H15N5O4·HCl,纯度大于98%。
溶解于水,可以配制成50mg/ml的水溶液。
包装清单:
产品编号 |
产品名称 |
包装 |
S0006 |
L-NAME(eNOS抑制剂) |
200mg |
— |
说明书 |
1份 |
保存条件:
-20℃避光保存,一年有效。
注意事项:
如果配制成水溶液,分装后-20℃保存,4个月内有效。
为了您的安全和健康,请穿实验服并戴一次性手套操作。
使用说明
使用说明:
1. L-NAME储备液的配制:称取少量L-NAME,推荐使用Milli-Q级纯水溶解L-NAME,使浓度为50mg/ml。
2. L-NAME的工作浓度通常为10-100μM。少数情况下浓度需达到500μM甚至5mM才可以观察到显著效果。 其最佳工作浓度需根据具体的实验,自行摸索。可以先分别尝试10、30和100μM这三个浓度。如果 效果不佳,可以尝试1μM等低浓度或300μM等更高浓度。
产品图片
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Role of nitric oxide in ischemia-reperfusion injury and acute rejection in rat
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Transplant Proc. 2008 Dec;40(10):3342-5.
2. Wang GF, Wu SY, Rao JJ, Lü L, Xu W, Pang JX, Liu ZQ, Wu SG, Zhang JJ.
Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical
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Acta Pharmacol Sin. 2009 May;30(5):589-96.
3. Zhong W, Zou G, Gu J, Zhang J.
L-arginine attenuates high glucose-accelerated senescence in human umbilical vein
endothelial cells.
Diabetes Res Clin Pract. 2010;89(1):38-45. Epub 2010 Apr 15.
4. Zhang QH, Zu XY, Cao RX, Liu JH, Mo ZC, Zeng Y, Li YB, Xiong SL, Liu X, Liao DF, Yi GH.
An involvement of SR-B1 mediated PI3K-Akt-eNOS signaling in HDL-induced cyclooxygenase
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Biochem Biophys Res Commun. 2012 Mar 30;420(1):17-23.
5. Li ZL, Liu JC, Liu SB, Li XQ, Yi DH, Zhao MG.
Improvement of vascular function by acute and chronic treatment with the GPR30 agonist
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Burdock fructooligosaccharide induces stomatal closure in Pisum sativum.
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9. Chen W, Wang J, Chen J, Chen J, Chen Z.
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10.Ma S, Zhang Z, Yi F, Wang Y, Zhang X, Li X, Yuan Y, Cao F.
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Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of
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30.
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