碧云天生物技术-Hoechst 33342活细胞染色液(100X)(C1028)

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Hoechst 33342活细胞染色液(100X)

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产品编号: C1028

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产品包装:0.5ml

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价格: ¥ 362.00

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产品编号	产品名称	产品包装	产品价格
C1027	Hoechst 33342活细胞染色液(100X)	0.1ml	111.00元
C1028	Hoechst 33342活细胞染色液(100X)	0.5ml	362.00元
C1029	Hoechst 33342活细胞染色液(100X)	3ml	1098.00元

Hoechst 33342活细胞染色液(100X) (Hoechst 33342 Staining Solution for Live Cells, 100X)，是一种适用于活细胞细胞核染色的溶液。仅需染色10分钟就能用荧光显微镜观察到非常明亮的细胞核蓝色荧光染色。
本产品也适用于固定后的细胞或组织的细胞核染色。
Hoechst 33342，也称bisBenzimide H 33342或HOE 33342。分子式为C₂₇H₂₈N₆O·3HCl·3H₂O，分子量为615.99，CAS Number 23491-52-3。Hoechst 33342的最大激发波长为346nm，最大发射波长为460nm；Hoechst 33342和双链DNA结合后，最大激发波长为350nm，最大发射波长为461nm。
Hoechst 33342是一种可以穿透细胞膜的蓝色荧光染料，对细胞的毒性较低。
Hoechst 33342染色常用于细胞凋亡检测，染色后用荧光显微镜观察或流式细胞仪检测。Hoechst 33342也常用于普通的细胞核染色，或常规的DNA染色。
本产品用于活细胞染色的效果图参考图1。

图1. 正常培养的HeLa细胞用本产品染色后的实拍效果图。图A为正常细胞Hoehst 33342的染色效果图。图B中除了正常细胞外，还清晰可见呈现致密浓染的凋亡细胞。

包装清单：

产品编号	产品名称	包装
C1028	Hoechst 33342活细胞染色液(100X)	0.5ml
―	说明书	1份

保存条件：
-20℃避光保存，一年有效。
注意事项：
本产品浓度经过碧云天的优化，确保可以满足活细胞染色及各种常规染色的需要。如需使用特定浓度的Hoechst 33342，请选购碧云天的粉末装Hoechst 33342 (C1022)。
荧光染料都存在淬灭的问题，建议染色后尽量当天完成检测。
为减缓荧光淬灭可以使用抗荧光淬灭封片液。抗荧光淬灭封片液(P0126)可以向碧云天订购。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1. 对于活细胞或培养的组织：
a. 对于培养器皿内的活细胞或组织，在培养液中均匀滴加适量的Hoechst 33342活细胞染色液(100X)至终浓度为1X，轻柔混匀。例如对于十二孔板中培养的细胞，每孔有1ml的培养液，每孔需要加入10μl Hoechst 33342活细胞染色液(100X)。培养液中的血清、酚红等都不会对染色产生干扰。
b. 在适宜于细胞培养的温度孵育10分钟。吸除含染料的培养液，用培养液或PBS洗涤2-3次即可在荧光显微镜下观察。细胞发生凋亡时，会看到凋亡细胞的细胞核呈致密浓染，或呈碎块状致密浓染。具体示例见图1。如果对于染色效果的要求不是特别高，染色5分钟，用培养液或PBS洗涤1次即可在荧光显微镜下观察。为避免凋亡细胞随培养液或PBS被吸除，在吸除液体前，对于用多孔板中培养的细胞，最好用多孔板离心机离心一下以充分沉淀那些已经漂浮起来的凋亡细胞。
2. 对于固定的细胞或组织：
a. 对于细胞或组织样品，固定后，适当洗涤去除固定剂。随后如果需要进行免疫荧光染色，则先进行免疫荧光染色，染色完毕后再按后续步骤进行Hoechst 33342染色。如果不需要进行其它染色，则直接进行后续的Hoechst 33342染色。
b. 对于贴壁细胞或组织切片，加入少量用免疫染色洗涤液、PBS或生理盐水稀释至1X的本产品，覆盖住样品即可。对于悬浮细胞，至少加入待染色样品体积3倍的染色液，混匀。室温放置3-5分钟。
c. 吸除Hoechst 33342染色液，用免疫染色洗涤液、PBS或生理盐水洗涤2-3次，每次3-5分钟。
d. 直接在荧光显微镜下观察或封片后荧光显微镜下观察。细胞发生凋亡时，会看到凋亡细胞的细胞核呈致密浓染，或呈碎块状致密浓染。
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Front Neurosci. 2021 Jan 13;14:589650. doi: 10.3389/fnins.2020.589650.

55. Minghui Li, Mengmeng Qin, Ge Song, Hailiang Deng, Dakuan Wang, Xueqing Wang, Wenbing Dai, Bing He, Hua Zhang, Qiang Zhang

A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens

Asian J Pharm Sci. 2021 Jan;16(1):97-109. doi: 10.1016/j.ajps.2020.06.006. (IF 3.968)

56. Qingshan Shen, Chunhui Zhang, Haizhen Mo, Hongru Zhang, Xiaojie Qin, Juan Li, Zhiqiang Zhang, Aurore Richel

Fabrication of chondroitin sulfate calcium complex and its chondrocyte proliferation in vitro

Carbohydr Polym. 2021 Feb 15;254:117282. doi: 10.1016/j.carbpol.2020.117282.

57. Lu Chen, Liucheng Zhang, Hongbo Zhang, Xiaoming Sun, Dan Liu, Jianming Zhang, Yuguang Zhang, Liying Cheng, Hélder A Santos, Wenguo Cui

Programmable immune activating electrospun fibers for skin regeneration

Bioact Mater. 2021 Mar 11;6(10):3218-3230. doi: 10.1016/j.bioactmat.2021.02.022.

58. Feng Yao, Zhen Jin, Xiaohan Lv, Zihan Zheng, Hongqian Gao, Ying Deng, Yizhen Liu, Lifang Chen, Weirong Wang, Jianyu He, Jianli Gu, Rong Lin

Hydroxytyrosol Acetate Inhibits Vascular Endothelial Cell Pyroptosis via the HDAC11 Signaling Pathway in Atherosclerosis

Front Pharmacol. 2021 Apr 23;12:656272. doi: 10.3389/fphar.2021.656272. (IF 4.225)

59. Hui Li, Nan Niu, Jihui Yang, Fei Dong, Tingrui Zhang, Shasha Li, Wei Zhao

Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway

Cell Biol Int. 2021 Aug;45(8):1784-1796. doi: 10.1002/cbin.11619. (IF 2.571)

60. Ling Hu, Xi Pan, Jinyue Hu, Hong Zeng, Xueting Liu, Manli Jiang, Binyuan Jiang

Proteasome inhibitors decrease paclitaxel‑induced cell death in nasopharyngeal carcinoma with the accumulation of CDK1/cyclin B1

Int J Mol Med. 2021 Oct;48(4):193. doi: 10.3892/ijmm.2021.5026. (IF 3.098)

61. Yuhan Liu, Jiabin Zhou, Yingying Luo, Jinxiao Li, Luorui Shang, Fangyuan Zhou, Shenglan Yang

Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo

Chin Med. 2021 Nov 29;16(1):127. doi: 10.1186/s13020-021-00541-z.

62. Qian Li, Hong Li, Xiuting Yao, Conghui Wang, Haiqing Liu, Dan Xu, Chenxi Yang, Hong Zhuang, Yu Xiao, Rui Liu, Sinuo Shen, Shaoyang Zhou, Chenge Fu, Yifan Wang, Gaojun Teng, Lijie Liu

Stress Response and Hearing Loss Differentially Contribute to Dynamic Alterations in Hippocampal Neurogenesis and Microglial Reactivity in Mice Exposed to Acute Noise Exposure

Front Neurosci. 2021 Dec 8;15:749925. doi: 10.3389/fnins.2021.749925.

63. Feifei Li, Xiaojie Zhao, Hao Li, Yu Liu, Yu Zhang, Xiaopeng Huang, Jia Cao, Fen Du, Dongfang Wu, Hong Yu

Hepatic lysosomal acid lipase drives the autophagy-lysosomal response and alleviates cholesterol metabolic disorder in ApoE deficient mice

Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Dec;1866(12):159027. doi: 10.1016/j.bbalip.2021.159027.

64. Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen, Xuan Zhang

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Drug Deliv. 2021 Dec;28(1):800-813. doi: 10.1080/10717544.2021.1909180. (IF 4.902)

65. Linhai Zhu, Ying Wang, Wang Lv, Xiao Wu, Hongxu Sheng, Cheng He, Jian Hu

Schizandrin A can inhibit non‑small cell lung cancer cell proliferation by inducing cell cycle arrest, apoptosis and autophagy

Int J Mol Med. 2021 Dec;48(6):214. doi: 10.3892/ijmm.2021.5047. (IF 3.098)

66. Hao Zhao, Yue Xu, Xinlei Song, Qingchen Zhang, Yajie Wang, Haiyan Yin, Xiaohui Bai, Jianfeng Li

Cisplatin induces damage of auditory cells: Possible relation with dynamic variation in calcium homeostasis and responding channels

Eur J Pharmacol. 2022 Jan 5:914:174662. doi: 10.1016/j.ejphar.2021.174662. (IF 3.263)

67. Fangfei Li, Xiaoqiu Wu, Xuekun Fu, Jin Liu, Wangze Song, Gary Guishan Xiao, Aiping Lu, Ge Zhang

Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation

Int J Biol Sci. 2022 Jan 9;18(3):1238-1253. doi: 10.7150/ijbs.58784. (IF 4.858)

68. Hanxun Yao, Xiaobin Li, Xuyan Pan, Jie Xu, Shufa Zhao, Zhongzhou Su, Sheng Qiu

Fraxetin exerts anticancer effect in glioma by suppressing MiR-21-3p

Drug Dev Res. 2022 Apr;83(2):501-511. doi: 10.1002/ddr.21881.

69. Lei Chen, Yang Yan, Fangen Kong, Jikai Wang, Jia Zeng, Zhen Fang, Zheyan Wang, Zhigang Liu, Fei Liu

Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells

Cancers (Basel). 2022 Apr 18;14(8):2036. doi: 10.3390/cancers14082036.

70. Jinrong Bai, Na Xie, Ya Hou, Xiaorui Chen, Yao Hu, Yi Zhang, Xianli Meng, Xiaobo Wang, Ce Tang

The enhanced mitochondrial dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-κB pathway activation

Biomed Pharmacother. 2022 May:149:112847. doi: 10.1016/j.biopha.2022.112847. (IF 4.545)

71. Pengpeng Duan, Jin Tan, Yuyang Miao, Qiang Zhang

PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury

Front Biosci (Landmark Ed). 2022 Jun 7;27(6):184. doi: 10.31083/j.fbl2706184.

72. Ruijun Bai, Michael Z Miao, Hui Li, Yiqing Wang, Ruixue Hou, Ke He, Xuan Wu, Hongyu Jin, Chao Zeng, Yang Cui, Guanghua Lei

Increased Wnt/β-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis

Arthritis Res Ther. 2022 Jul 8;24(1):165. doi: 10.1186/s13075-022-02848-0. (IF 4.103)

73. Yukang Wen, Zhengkun Chen, Yaqin Tian, Mei Yang, Qingshuang Dong, Yujiao Yang, Honglei Ding

Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages

Vet Res. 2022 Aug 4;53(1):62. doi: 10.1186/s13567-022-01074-5. (IF 3.357)

74. Xin Xu, Xiao-Fang Xie, Yan-Hong Dong, Hui-Qiong Zhang, Cheng Peng

Ginsenoside Rg1 Reduces Cardiotoxicity While Increases Cardiotonic Effect of Aconitine in vitro

Chin J Integr Med. 2022 Aug;28(8):693-701. doi: 10.1007/s11655-022-3509-0. (IF 1.545)

75. Dandan Feng, Jiang Li, Liang Guo, Jing Liu, Shaochen Wang, Xiuyuan Ma, Yunxuan Song, Ju Liu, Enkui Hao

DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating Wnt/β-catenin signaling pathway in an in vitro model

J Biochem Mol Toxicol. 2022 Aug;36(8):e23077. doi: 10.1002/jbt.23077.

76. Yang Zhang, Fei He, Yanning Zhang, Qian Dai, Qintong Li, Jing Nan, Ruidong Miao, Bo Cheng

Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Ca

Mob DNA. 2022 Nov 10;13(1):25. doi: 10.1186/s13100-022-00279-x.

77. Tao Tao, Xiangxin Chen, Yan Zhou, Qiang Zheng, Sen Gao, Jinwei Wang, Pengfei Ding, Xiaojian Li, Zheng Peng, Yue Lu, Yongyue Gao, Zong Zhuang, Chun-Hua Hang, Wei Li

Continued P2X7 activation leads to mitochondrial fission and compromising microglial phagocytosis after subarachnoid haemorrhage

J Neurochem. 2022 Dec;163(5):419-437. doi: 10.1111/jnc.15712. (IF 4.066)

78. Xiancheng Qiu, Qianke Tao, Lihan Zhang, Chenghao Kuang, Yuke Xie, Lifang Zhang, Shigang Yin, Jianhua Peng, Yong Jiang

Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage

J Neurochem. 2023 Mar;164(6):829-846. doi: 10.1111/jnc.15751. (IF 4.066)

79. Yilong Yao, Yunlu Wang, Fupeng Wang, Chaoyi Meng, Jiaqiang Niu, Ming Guo, Suolang Sizhu, Yefen Xu

BMP15 Modulates the H19/miR-26b/SMAD1 Axis Influences Yak Granulosa Cell Proliferation, Autophagy, and Apoptosis

Reprod Sci. 2023 Apr;30(4):1266-1280. doi: 10.1007/s43032-022-01051-5. (IF 2.616)