微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SD4758-10mM | Pyridone 6 (JAK抑制剂) | 10mM×0.2ml | 249.00元 |
| SD4758-5mg | Pyridone 6 (JAK抑制剂) | 5mg | 1337.00元 |
| SD4758-25mg | Pyridone 6 (JAK抑制剂) | 25mg | 3226.00元 |
化学信息：
| 化学名 | 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one |
|
| 简称 | Pyridone 6 | |
| 别名 |
CMP 6, JAK Inhibitor, CMP-6 |
|
| 中文名 | N/A | |
| 化学式 | C18H16FN3O | |
| 分子量 | 309.34 | |
| CAS号 | 457081-03-7 | |
| 纯度 | 98% | |
| 溶剂/溶解度 |
Water<1mg/ml; DMSO5mg/ml; Ethanol<1mg/ml |
|
| 溶液配制 | 5mg加入1.62ml DMSO，或者每3.09mg加入1ml DMSO，配制成10mM溶液。SD4758-10mM用DMSO配制。 |
生物信息：
| 产品描述 | Pyridone 6 (CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15nM, murine JAK1), JAK2 (IC50=1nM), JAK3 (Ki=5nM), and Tyk2 (IC50=1nM); displaying significantly weaker affinities (130nM to 10mM) for other protein tyrosine kinases. | ||||
| 信号通路 | JAK/STAT | ||||
| 靶点 | JAK1 | JAK2 | JAK3 | Try2 | － |
| IC50 | 15nM | 1nM | 5nM | 1nM | － |
| 体外研究 | Pyridone 6, a pan-JAK inhibitor, delayed the onset and reduced the magnitude of skin disease in an AD-like skin-disease model of NC/Nga mice. Pyridone 6 displays potent inhibitory activity against JAK1 (IC50=15nM for murine JAK1), JAK2 (IC50=1nM), JAK3 (Ki=5nM), and Tyk2 (IC50=1nM). Pyridone 6 is therapeutic for AD by modulating the balance of Th2 and Th17. JAK inhibitor Pyridone 6 suppresses asthmatic responses by inhibiting Th2 inflammation and that application of PLGA nanoparticles improves the therapeutic potency of Pyridone 6. Inhibition of JAK may be useful for the treatment of bone-resorptive diseases, such as osteoporosis. Pyridone 6 is a more sensitive and specific inhibitor of JAK-STAT3 activity compared with AG490 and potently inhibited the growth of primary myeloma cells and myeloma-derived cell lines grown on BMSCs. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SD4758-10mM | Pyridone 6 (JAK抑制剂) | 10mM×0.2ml |
| SD4758-5mg | Pyridone 6 (JAK抑制剂) | 5mg |
| SD4758-25mg | Pyridone 6 (JAK抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
微信在线咨询
