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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1135-10mM | 蛇床子素(98%, HPLC) | 10mM×0.2ml | 72.00元 |
| SM1135-25mg | 蛇床子素(98%, HPLC) | 25mg | 96.00元 |
| SM1135-100mg | 蛇床子素(98%, HPLC) | 100mg | 326.00元 |
| 中文名 | 蛇床子素 |
| 英文名 | Osthole |
| 中文别名 | 蛇床籽素；王草脑；欧芹酚甲醚 |
| 英文别名 | Osthenol methylether |
| 来源 | 重齿毛当归Angelica pubescens Maxim. f. biserrata Shan et Yuan |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>香豆素(Coumarins)>角型呋喃香豆素 |
| 化学式 | C15H16O3 |
| 分子量 | 244.29 |
| CAS号 | 484-12-8 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 100 mg/ml (409.35 mM) |
| 溶液配制 | 3mg加入1.23ml DMSO，或者每2.44mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells. | ||||
| 信号通路 | - | ||||
| 靶点 | Histamine Receptor | HBV | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Osthole (p<0.0001) and Fexofenadine (p<0.001) inhibit increased HRH-1 mRNA expression induced by histamine in the study group. This result is also observed in cells cultured with histamine/Osthole; where combined substances decreased HRH-1 mRNA expression compared to histamine (p<0.0001)1. Assessment of cell viability does not detect obvious toxicity when Osthole is used at a dose up to 100 µM. However, when the dose reached 500 µM, Osthole started to show toxic effect. Based on these observations, Osthole is used in all in vitro studies at the dose range of 10 to 100 µM. Osthole dose-dependently promotes osteoblast differentiation, as shown by the upregulation of osteoblast differentiation marker genes such as type I collagen (col1), bone sialoprotein (BSP) and osteocalcin (OC) (2 days of culture). Osthole promotes ALP activity in mouse primary osteoblasts in a dose-dependent manne. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1.Kordulewska NK, et al. Immunobiology. 2017,222(3):571-581.
2.Tang DZ, et al. J Bone Miner Res. 2010,25(6):1234-45.
3.Sun W, et al. Acta Pharmacol Sin. 2017,38(8):1120-1128.
4.Zhang ZR, et al. Evid Based Complement Alternat Med. 2015:919616.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1135-10mM | 蛇床子素(98%, HPLC) | 10mM×0.2ml |
| SM1135-25mg | 蛇床子素(98%, HPLC) | 25mg |
| SM1135-100mg | 蛇床子素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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