产品编号 | 产品名称 | 产品包装 | 产品价格 |
SM1152-10mM | 异补骨脂素(98%, HPLC) | 10mM×0.2ml | 72.00元 |
SM1152-25mg | 异补骨脂素(98%, HPLC) | 25mg | 132.00元 |
SM1152-100mg | 异补骨脂素(98%, HPLC) | 100mg | 448.00元 |
中文名 | 异补骨脂素 |
英文名 | Angelicin |
中文别名 | 当归素;异香柠檬烯;异佛手柑内酯;异补骨酯素 |
英文别名 | Isopsoralen; Bakuchicin |
来源 | 补骨脂Psoralea corylifolia Linn. |
化合物类型 | 苯丙素类(Phenylpropanoids)>香豆素类(Coumarins)>角型呋喃香豆素 |
化学式 | C11H6O3 |
分子量 | 186.16 |
CAS号 | 523-50-2 |
纯度 | 98%, HPLC |
溶剂/溶解度 |
Water: < 0.1 mg/ml (insoluble); DMSO: 33.33 mg/ml (179.04 mM) |
溶液配制 | 2mg加入1.07ml DMSO,或者每1.86mg加入1ml DMSO,配制成10mM溶液。 |
产品描述 | Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. | ||||
信号通路 | Apoptosis | ||||
靶点 | - | - | - | - | - |
IC50 | - | - | - | - | - |
体外研究 | In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways. | ||||
体内研究 | N/A | ||||
临床实验 | N/A |
1.Md. Ataur Rahman, et al. Molecular and Cellular Biochemistry. 2012,369(1-2):95-104.
2.Hye-Jeong Cho, et al. Antiviral Research. 2013,100(1):75-83.
3.Fang Liu, et al. Journal of Surgical Research. 2013,185(1):300-309.
包装清单:产品编号 | 产品名称 | 包装 |
SM1152-10mM | 异补骨脂素(98%, HPLC) | 10mM×0.2ml |
SM1152-25mg | 异补骨脂素(98%, HPLC) | 25mg |
SM1152-100mg | 异补骨脂素(98%, HPLC) | 100mg |
- | 说明书 | 1份 |
-20℃保存,至少一年有效。固体粉末4℃保存,至少一个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。
注意事项:本产品可能对人体有一定的毒害作用,请注意适当防护,以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。