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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4048-10mM | 氧化苦参碱(98%, HPLC) | 10mM×0.2ml | 73.00元 |
| SM4048-25mg | 氧化苦参碱(98%, HPLC) | 25mg | 100.00元 |
| SM4048-100mg | 氧化苦参碱(98%, HPLC) | 100mg | 340.00元 |
| 中文名 | 氧化苦参碱 |
| 英文名 | Oxymatrine |
| 中文别名 | - |
| 英文别名 | Matrine N-oxide；Oxysophoridine |
| 来源 | 越南槐Sophora tonkinensis Gagnep.；苦参Sophora flavescens Alt. |
| 化合物类型 | 生物碱(Alkaloids)>喹诺里西啶类生物碱 |
| 化学式 | C15H24N2O2 |
| 分子量 | 264.36 |
| CAS号 | 16837-52-8 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO：100 mg/mL (378.27 mM); Water：100 mg/mL (378.27 mM) |
| 溶液配制 | 3mg加入1.13ml DMSO，或者每2.64mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Oxymatrine, an alkaloid from the roots of Sophora species, with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection. | ||||
| 信号通路 | TGF-beta/Smad | ||||
| 靶点 | iNOS | MVC | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Oxymatrine, an alkaloid component extracted from the roots of Sophora species, has been shown to have antiinflammatory, antifibrosis, and antitumor effects and the ability to protect against myocardial damage, etc. The potential signaling pathways involved in the clinical application of oxymatrine might include the TGF-β/Smad, tolllike receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells, toll-like receptor9/TRAF6, Janus kinase/signal transduction and activator of transcription, phosphatidylinositol-3 kinase/Akt, delta-opioid receptorarrestinl-Bcl-2, CD40, epidermal growth factor receptor, nuclear factor erythroid-2-related factor 2/hemeoxygenase-1 signaling pathways, and dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine metabolism pathway. Oxymatrine significantly inhibits the proliferation of DU145 and PC-3 cell lines in a time- and dose-dependent manner. By contrast, following treatment with oxymatrine, PNT1B healthy human prostate cell proliferation is not inhibited. | ||||
| 体内研究 | The volume and weight of tumors in mice significantly decreased in a dose-dependent manner. Oxymatrine may reduce prostate cancer cell growth by promoting cell apoptosis in vivo. Oxymatrine is effective in reducing the production and deposition of collagen in the liver tissue of experimental rats. Oxymatrine could promote the expression of Smad 7 and inhibit the expression of Smad 3 and CBP in CCl4-induced hepatic fibrosis in SD rats, could modulate the fibrogenic signal transduction of TGFβ-Smad pathway. | ||||
| 临床实验 | N/A | ||||
1.Lu ML, et al. Phytother Res. 2016,30(7):1104-12.
2.Wu C, et al. Mol Med Rep. 2015,11(6):4129-34.
3.Wu XL, et al. World J Gastroenterol. 2008,14(13):2100-5.
4.Ding Y, et al. Virol Sin. 2019,34(1):78-87.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4048-10mM | 氧化苦参碱(98%, HPLC) | 10mM×0.2ml |
| SM4048-25mg | 氧化苦参碱(98%, HPLC) | 25mg |
| SM4048-100mg | 氧化苦参碱(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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