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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5148-25mg | 丹参酮IIA (98%, HPLC) | 25mg | 120.00元 |
| SM5148-100mg | 丹参酮IIA (98%, HPLC) | 100mg | 408.00元 |
| 中文名 | 丹参酮IIA |
| 英文名 | Tanshinone IIA |
| 中文别名 | - |
| 英文别名 | Tanshinone B;Dan Shen ketone |
| 来源 | 丹参Salvia miltiorrhiza Bunge |
| 化合物类型 | 生物合成：萜类(Terpenoids)>二萜(含有松香烷型骨架的20–去甲二萜类化合物)；结构上：菲醌 |
| 化学式 | C19H18O3 |
| 分子量 | 294.34 |
| CAS号 | 568-72-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 3.85 mg/mL (13.08 mM) |
| 溶液配制 | 5mg加入1.70ml DMSO，或者每2.94mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Tanshinone IIA is the diterpene quinone in Danshen, which is utilized in the treatment of cardiovascular and inflammatory. Tanshinone IIA is utilized in the treatment of cardiovascular and inflammatory. | ||||
| 信号通路 | Apoptosis; PI3K/Akt/mTOR | ||||
| 靶点 | VEGF | VEGFR2 | PTEN | EGFR | IGFR |
| IC50 | - | - | - | - | - |
| 体外研究 | The anti-tumor effect of Tanshinone IIA includes inhibiting tumor cell proliferation, disturbing tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer. Tanshinone IIA has anti-proliferative effects on A549 cells: the IC50 of Tanshinone IIA after 24, 48 and 72 h are 145.3, 30.95 and 11.49 μM, respectively. The CCK-8 assay is used to evaluate the proliferative activity of A549 cells treated with Tanshinone IIA (2.5-80 μM) for 24, 48 and 72 h, respectively. The CCK-8 results show that Tanshinone IIA can significantly inhibit A549 cell proliferation in a dose- and time-dependent manner. Obvious apoptosis and cell growth inhibition of A549 cells are observed after drug treatment for 48 h (concentrations used are approximately IC50 values: Tanshinone IIA 31 μM on A549). Western blotting finds that 48 h exposures to Tanshinone IIA (31 μM) in A549 cells, downregulates expression of VEGF and VEGFR2 protein in both drug treatment groups vs. vehicle. Tanshinone IIA, one of the most abundant constituents of the root of Salvia miltiorrhiza, protects rat myocardium-derived H9C2 cells against apoptosis. Treatment of H9C2 cells with Tanshinone IIA inhibits angiotensin II-induced apoptosis by downregulating the expression of PTEN (phosphatase and tensin homolog), a tumor suppressor that plays a critical role in apoptosis. Tanshinone IIA inhibits angiotensin II (AngII)-induced apoptosis by downregulating the expression of phosphatase and tensin homolog (PTEN). Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1.Xie J, et al. Acta Pharm Sin B. 2015,5(6):554-63.
2.Zhang Z, et al. Am J Transl Res. 2016,8(7):3124-32.
3.Su CC, et al. Oncol Rep. 2016, 36(2):1173-9.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5148-25mg | 丹参酮IIA (98%, HPLC) | 25mg |
| SM5148-100mg | 丹参酮IIA (98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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