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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6032-10mM | 人参皂苷Rb1 (98%, HPLC) | 10mM×0.2ml | 99.00元 |
| SM6032-25mg | 人参皂苷Rb1 (98%, HPLC) | 25mg | 120.00元 |
| SM6032-100mg | 人参皂苷Rb1 (98%, HPLC) | 100mg | 408.00元 |
| 中文名 | 人参皂苷Rb1 |
| 英文名 | Ginsenoside Rb1 |
| 中文别名 | - |
| 英文别名 | Sanchinoside E1; Gypenoside III; Gynosaponin C |
| 来源 | 人参Panax ginseng C. A. Meyer |
| 化合物类型 | 萜类(Terpenoids)>三萜>达玛烷型四环三萜皂苷 |
| 化学式 | C54H92O23 |
| 分子量 | 1109.29 |
| CAS号 | 41753-43-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (90.15 mM) |
| 溶液配制 | 15mg加入1.35ml DMSO，或者每11.09mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. | ||||
| 信号通路 | Autophagy; HSV-1 | ||||
| 靶点 | Na+, K+-ATPase | IRAK-1 | NF-κB p65 | - | - |
| IC50 | 6.3±1.0 μM | - | - | - | - |
| 体外研究 | Rat brain microsomal Na+, K+-ATPase activity is inhibited significantly and rapidly by Ginsenoside Rb1. The IC50 of Ginsenoside Rb1 for Na+, K+-ATPase is 6.3±1.0 μM. The inhibition is enhanced with increasing the concentration of Ginsenoside Rb1 or decreasing that of Na+ and K+. Kinetic analysis reveals that Ginsenoside is an uncompetitive inhibitor with respect to ATP. Ginsenoside Rb1 significantly inhibits the activation of interleukin-1 receptor-associated kinase-1 (IRAK-1), IKK-β, NF-κB, and MAP kinases (ERK, JNK, and p-38); however, interaction between LPS and Toll-like receptor-4, IRAK-4 activation and IRAK-2 activation are unaffected. Ginsenoside Rb1 is an ingredient of a Chinese medicine Panax ginseng. Ginsenoside Rb1 is a major bioactive compound in the regulating pregnane X receptor (PXR)/NF-κB signaling. Ginsenoside Rb1 is the compound with potent anti-inflammatory activity in ginseng saponin extract (GSE). The concentration for Ginsenoside Rb1 (10 μM) is optimized from a preliminary study to ensure sufficient anti-inflammatory activity and without apparent cytotoxicity. Ginsenoside Rb1 significantly reduces TNF-α-induced upregulation of IL-1β and iNOS mRNA levels, and restores the mRNA levels of PXR and CYP3A4 in LS174T cells. TNF-α causes a significant reduction in PXR protein levels and increase in the ratio of phosphorylated to total NF-κB p65, both of which are significantly abrogated by Ginsenoside Rb1. | ||||
| 体内研究 | Ginsenoside Rb1 at the both doses of 30 mg/kg and 60 mg/kg significantly attenuates the histological lung injury. Ginsenoside Rb1 at the dose of 30 mg/kg and 60 mg/kg both significantly attenuates the histological intestine injury. Ginsenoside Rb1 (Rb1), an ingredient of a Chinese medicine Panax ginseng, has beneficial effects on mesentery microvascular hyperpermeability induced by Lipopolysaccharide (LPS) and the underlying mechanisms. In some rats, Ginsenoside Rb1 (5 mg/kg per hour) is administrated through the left jugular vein 30 min after LPS infusion. Ginsenoside Rb1 decreases caveolae number in endothelial cells of microvessels. Ginsenoside Rb1 ameliorates microvascular hyperpermeability after the onset of endotoxemia and improves intestinal edema through inhibiting caveolae formation and junction disruption, which is correlated to suppression of NF-κB and Src activation. | ||||
| 临床实验 | N/A | ||||
1.Cao J, et al. Zhongguo Yao Li Xue Bao. 1990,11(1):10-4.
2.Zhang J, et al. Drug Metab Dispos. 2015,43(8):1181-9.
3.Joh EH, et al. Biochem Pharmacol. 2011,82(3):278-86.
4.Jiang Y, et al. Oxid Med Cell Longev. 2015:843721.
5.Zhang Y, et al. Am J Physiol Gastrointest Liver Physiol. 2014,306(4):G289-300.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6032-10mM | 人参皂苷Rb1 (98%, HPLC) | 10mM×0.2ml |
| SM6032-25mg | 人参皂苷Rb1 (98%, HPLC) | 25mg |
| SM6032-100mg | 人参皂苷Rb1 (98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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