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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6056-10mM | 常春藤皂苷元(98%, HPLC) | 10mM×0.2ml | 112.00元 |
| SM6056-5mg | 常春藤皂苷元(98%, HPLC) | 5mg | 94.00元 |
| SM6056-25mg | 常春藤皂苷元(98%, HPLC) | 25mg | 390.00元 |
| SM6056-100mg | 常春藤皂苷元(98%, HPLC) | 100mg | 1326.00元 |
化学信息：
| 中文名 | 常春藤皂苷元 |
| 英文名 | Hederagenin |
| 中文别名 | - |
| 英文别名 | - |
| 来源 | 黑种草Nigella glandulifera Freyn et Sint.；常春藤Hedera nepalensis var. sinensis (Tobl.) Rehd |
| 化合物类型 | 萜类(Terpenoids)>三萜>齐墩果烷型五环三萜 |
| 化学式 | C30H48O4 |
| 分子量 | 472.71 |
| CAS号 | 465-99-6 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 50 mg/ml (105.78 mM) |
| 溶液配制 | 5mg加入1.06ml DMSO，或者每4.73mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Hederagenin is a triterpenoid saponin. It can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB Hederagenin can Exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antilipid peroxidation, antiplatelet aggregation, liver protection, antidepression, anti-inflammation. | ||||
| 信号通路 | - | ||||
| 靶点 | iNOS | COX-2 | NF-κB | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Hederagenin can correct the imbalance of endothelial function by inhibiting the release of large amounts of iNOS and increasing eNOS contents and inhibits the IKKβ/NF-κB signaling pathway to reduce the release of IL-6, IFN-γ, TNF-α, and other inflammatory factors. The EC50 of hederagenin is 39 ± 6 μM in A549 cancer cell line, but it's inactive for DLD-1 cells. Hederagenin inhibited LPS-induced production of NO, PGE2and cytokines in cells. Hederagenin had an anti-edema effect on the CA-induced mouse hind paw edema assay.Hederagenin inhibited the CA-induced increase in skin thicknesses. | ||||
| 体内研究 | The rats in the hederagenin group were administered hederagenin at 20 mg/kg/d via gavage. In AS rat models induced by a high-lipid diet plus VD3, hederagenin can effectively reduce serum lipid, ALT, and AST levels, in addition to improving liver function, relieving high blood coagulation, and slowing blood flow and stasis by improving blood rheology. | ||||
| 临床实验 | N/A | ||||
1. Su-Hong Lu et al. Evid Based Complement Alternat Med, 2015,2015:456354.
2. Diego Rodríguez-Hernández et al. Eur J Med Chem, 2015,105:57-62
3. Chul Won Lee et al. Int Immunopharmacol, 2015,29(2):528-37.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6056-10mM | 常春藤皂苷元(98%, HPLC) | 10mM×0.2ml |
| SM6056-5mg | 常春藤皂苷元(98%, HPLC) | 5mg |
| SM6056-25mg | 常春藤皂苷元(98%, HPLC) | 25mg |
| SM6056-100mg | 常春藤皂苷元(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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