微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6060-10mM | 齐墩果酸(98%, HPLC) | 10mM×0.2ml | 74.00元 |
| SM6060-25mg | 齐墩果酸(98%, HPLC) | 25mg | 70.00元 |
| SM6060-100mg | 齐墩果酸(98%, HPLC) | 100mg | 238.00元 |
| 中文名 | 齐墩果酸 |
| 英文名 | Oleanolic acid |
| 中文别名 | - |
| 英文别名 | Oleanol; Caryophyllin |
| 来源 | 枇杷叶Eriobotrya japonica Thunb. |
| 化合物类型 | 萜类(Terpenoids)>三萜>齐墩果烷型五环三萜 |
| 化学式 | C30H48O3 |
| 分子量 | 456.70 |
| CAS号 | 508-02-1 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: 5 mg/ml (10.95 mM); Water: < 0.1 mg/ml (insoluble) |
| 溶液配制 | 5mg加入1.09ml DMSO，或者每4.57mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities. | ||||
| 信号通路 | Autophagy; p38 MAPK; JNK; ERK | ||||
| 靶点 | CCNG1 | MEF2D | IL-10 | IL-35 | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Oleanolic acid (OA) suppresses the proliferation of lung cancer cells in both dose- and time-dependent manners, along with an increase in miR-122 abundance. CCNG1 and MEF2D, two putative miR-122 targets, are found to be downregulated by OA treatment. OA induces autophagy in normal tissue-derived cells without cytotoxicity. OA-induced autophagy is shown to decrease the proliferation of KRAS-transformed normal cells and to impair their invasion and anchorage-independent growth. | ||||
| 体内研究 | Mouse model experiments also demonstrat that OA suppresses the growth of KRAS-transformed breast epithelial cell MCF10A-derived tumor xenograft by inducing autophagy. Activation of MAPK pathways, including p-38 MAPK, JNK and ERK, is triggered by OA in both a dose and time-dependent fashion in all the tested cancer cells. OA induces p38 MAPK activation promoted mitochondrial translocation of Bax and Bim, and inhibits Bcl-2 function by enhancing their phosphorylation. OA can induce reactive oxygen species (ROS)-dependent ASK1 activation, and this event is indispensable for p38 MAPK-dependent apoptosis in cancer cells.It is also proved that p38 MAPK knockdown A549 tumors are resistant to the growth-inhibitory effect of OA. In OA-treated EAM mice the number of Treg cells and the production of IL-10 and IL-35 are markedly increased, while proinflammatory and profibrotic cytokines are significantly reduced. | ||||
| 临床实验 | NCT01674946: Echolocation, Phase 1. | ||||
1.Zhao X, et al. Mol Cell Biochem. 2015,400(1-2):1-7.
2.Liu J, et al. J Nutr Biochem. 2014,25(11):1154-60.
3.Liu J, et al. Asian Pac J Cancer Prev. 2014,15(11):4519-25.
4.Martín R, et al. J Mol Cell Cardiol. 2014,72:250-62.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6060-10mM | 齐墩果酸(98%, HPLC) | 10mM×0.2ml |
| SM6060-25mg | 齐墩果酸(98%, HPLC) | 25mg |
| SM6060-100mg | 齐墩果酸(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
